Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D

Detalhes bibliográficos
Autor(a) principal: Palczewski, Raphael Henrique
Data de Publicação: 2016
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações do UNIOESTE
Texto Completo: http://tede.unioeste.br/handle/tede/2952
Resumo: The plasma vitamin D plays a key role in regulating calcium and phosphate homeostasis with activity on liver, intestine, kidney and bone. Calcium and phosphate obtained through the diet, are environmental elements necessary together with Vitamin D to determine whether 1,25-hydroxyvitamin D exerts an anabolic or catabolic effect on bone mineral appearance. This research was conducted to evaluate the effect of vitamin D3 supplementation exerts on the bone density of the femur and mice jaw. mice were used C57BL / 6 males and females, were divided into two groups: 1) control group (n = 24) and 2) experimental group (n = 24) - subject to systemic administration of vitamin D by means of vitamin D3 gavage (VITD) at a concentration of 10,000 IU for week. After 4 weeks of administration of Vitamin D was performed surgery for placement of titanium implants in the lateral region of the mandible and animals were sacrificed within 7 and 21 days after implant placement. Histomorphometric analyzes were carried out in the regions of femoral metaphysis and jaw through digital LAZ v4.2 and radiographic program and analyzed by BA-DDX program through digital periapical, where it was verified that there was an increase in bone density among the groups through the trabecular pixel count. For the statistical analysis were applied Anova and Bonferroni multiple correlation and Kruskal Wallis test. The results of histomorphometric analysis showed no difference in bone structures (trabecular and marrow spaces) in the jaw evaluated by vitamin D3 supplementation at 7 and 21 days of healing. The results of radiographic however, showed that the jaw was no increase in bone density in the supplemented group compared to the control group (p <0.05), without however, differences in the same group over time (7 and 21 days). The femur there was no difference between control and experimental groups over time, in the metaphyseal region, however, in the diaphyseal region noticed an increase in the number of pixels trabecular in the supplemented group compared to the control group (p = 0.001). It can be concluded that by the structures evaluated in the histomorphometric analysis, supplementation with vitamin D3 had no effect on bone parameters of the jaw and femur, but the radiographic analysis showed an increase in bone density between the control and experimental groups in the jaw to around the implant and femoral diaphysis.
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spelling Togashi, Adriane Yaekohttp://lattes.cnpq.br/2205570443795384Luize, Danielle Shimahttp://lattes.cnpq.br/3315242658841066Togashi, Adriane Yaekohttp://lattes.cnpq.br/2205570443795384Rangel, Ana Lúcia Carrinho Ayrozahttp://lattes.cnpq.br/1438147088984375Fujimaki, Mitsuehttp://lattes.cnpq.br/2807927162629148http://lattes.cnpq.br/3660874694838754Palczewski, Raphael Henrique2017-08-29T14:15:55Z2016-04-04PALCZEWSKI, Raphael Henrique. Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D. 2016. 54 f. Dissertação ( Mestrado em Odontologia) - Universidade Estadual do Oeste do Paraná, Cascavel, 2016.http://tede.unioeste.br/handle/tede/2952The plasma vitamin D plays a key role in regulating calcium and phosphate homeostasis with activity on liver, intestine, kidney and bone. Calcium and phosphate obtained through the diet, are environmental elements necessary together with Vitamin D to determine whether 1,25-hydroxyvitamin D exerts an anabolic or catabolic effect on bone mineral appearance. This research was conducted to evaluate the effect of vitamin D3 supplementation exerts on the bone density of the femur and mice jaw. mice were used C57BL / 6 males and females, were divided into two groups: 1) control group (n = 24) and 2) experimental group (n = 24) - subject to systemic administration of vitamin D by means of vitamin D3 gavage (VITD) at a concentration of 10,000 IU for week. After 4 weeks of administration of Vitamin D was performed surgery for placement of titanium implants in the lateral region of the mandible and animals were sacrificed within 7 and 21 days after implant placement. Histomorphometric analyzes were carried out in the regions of femoral metaphysis and jaw through digital LAZ v4.2 and radiographic program and analyzed by BA-DDX program through digital periapical, where it was verified that there was an increase in bone density among the groups through the trabecular pixel count. For the statistical analysis were applied Anova and Bonferroni multiple correlation and Kruskal Wallis test. The results of histomorphometric analysis showed no difference in bone structures (trabecular and marrow spaces) in the jaw evaluated by vitamin D3 supplementation at 7 and 21 days of healing. The results of radiographic however, showed that the jaw was no increase in bone density in the supplemented group compared to the control group (p <0.05), without however, differences in the same group over time (7 and 21 days). The femur there was no difference between control and experimental groups over time, in the metaphyseal region, however, in the diaphyseal region noticed an increase in the number of pixels trabecular in the supplemented group compared to the control group (p = 0.001). It can be concluded that by the structures evaluated in the histomorphometric analysis, supplementation with vitamin D3 had no effect on bone parameters of the jaw and femur, but the radiographic analysis showed an increase in bone density between the control and experimental groups in the jaw to around the implant and femoral diaphysis.A vitamina D no plasma desempenha um papel chave na regulação do cálcio e homeostase do fosfato com atividades sobre fígado, intestino, rim e osso. Cálcio e o fosfato, obtidos por meio da dieta, são elementos ambientais necessários juntos com a vitamina D para determinar se 1,25-hidroxivitamina D exerce um efeito anabólico ou catabólico sobre o aspecto mineral ósseo. Esta pesquisa foi realizada para avaliar a influência da suplementação de vitamina D3 exerce sobre a densidade óssea do fêmur e mandíbula de camundongos. Foram utilizados camundongos C57BL/6 machos e fêmeas, divididos em dois grupos: 1) grupo controle (n=24) e 2) grupo experimental (n=24) - submetidos à administração sistêmica de vitamina D, por meio de gavagem de vitamina D3 (VitD) na concentração de 10.000 UI por semana. Após 4 semanas da administração da vitamina D foi realizada a cirurgia para colocação de implantes de titânio na região lateral da mandíbula dos animais e foram sacrificados num período de 7 e 21 dias após a colocação do implante. Foram realizadas análises histomorfométrica das regiões de metáfise femoral e mandíbula por meio do programa LAZ v4.2 e radiográfica digital e analisados pelo programa BA-DDX através de radiografia periapical digital, onde foi verificado se houve aumento na densidade óssea entre os grupos analisados através da contagem de pixels de trabeculares. Para a análise estatística foram aplicados os testes Anova e correlação múltipla de Bonferroni e teste de Kruskall Wallis. Os resultados da análise histomorfométrica não mostraram diferenças nas estruturas ósseas (trabéculas e espaços medulares) avaliadas na mandíbula mediante a suplementação de vitamina D3 nos períodos de 7 e 21 dias de cicatrização. Os resultados da análise radiográfica contudo, demonstraram que na mandíbula houve aumento na densidade óssea no grupo suplementado em relação ao grupo controle (p<0,05), não havendo entretanto, diferença no mesmo grupo ao longo do tempo (7 e 21 dias). No fêmur não houve diferença entre grupos controle e experimental ao longo do tempo, na região de metáfise, porém, na região de diáfise notou-se um aumento no número de pixels trabeculares no grupo suplementado em comparação ao grupo controle (p=0,001). Pode-se concluir que pelos pelas estruturas avaliadas na análise histomorfométrica, a suplementação com vitamina D3 não apresentou influência sobre os parâmetros ósseos da mandíbula e do fêmur, porém a análise radiográfica demonstrou um aumento na densidade óssea entre os grupos controle e experimental na mandíbula ao redor do implante e diáfise femoral.Submitted by Rosangela Silva (rosangela.silva3@unioeste.br) on 2017-08-29T14:15:55Z No. of bitstreams: 2 Dissertação Raphael.pdf: 2502185 bytes, checksum: 8f01f9c4d9e3e59032b2f45ae01ebd24 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2017-08-29T14:15:55Z (GMT). No. of bitstreams: 2 Dissertação Raphael.pdf: 2502185 bytes, checksum: 8f01f9c4d9e3e59032b2f45ae01ebd24 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-04-04Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfpor6588633818200016417500Universidade Estadual do Oeste do ParanáCascavelPrograma de Pós-Graduação em OdontologiaUNIOESTEBrasilCentro de Ciências Biológicas e da Saúdehttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessVitamina DDensidade ósseaRemodelação ósseaSuplementaçãoVitamin DBone densityBone remodelingSupplementationCIENCIAS DA SAUDE::ODONTOLOGIACaracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina DHistomorphometric and radiographic characterization of the mandible and femur bone tissue of mice supplemented with vitamin Dinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-80965548187336651646006006006001458059979463924370-20704984698792443492075167498588264571reponame:Biblioteca Digital de Teses e Dissertações do UNIOESTEinstname:Universidade Estadual do Oeste do Paraná (UNIOESTE)instacron:UNIOESTEORIGINALRaphael.Palczewski2016pdfRaphael.Palczewski2016pdfapplication/pdf2502185http://tede.unioeste.br:8080/tede/bitstream/tede/2952/5/Raphael.Palczewski2016pdf8f01f9c4d9e3e59032b2f45ae01ebd24MD55CC-LICENSElicense_urllicense_urltext/plain; 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dc.title.por.fl_str_mv Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D
dc.title.alternative.eng.fl_str_mv Histomorphometric and radiographic characterization of the mandible and femur bone tissue of mice supplemented with vitamin D
title Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D
spellingShingle Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D
Palczewski, Raphael Henrique
Vitamina D
Densidade óssea
Remodelação óssea
Suplementação
Vitamin D
Bone density
Bone remodeling
Supplementation
CIENCIAS DA SAUDE::ODONTOLOGIA
title_short Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D
title_full Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D
title_fullStr Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D
title_full_unstemmed Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D
title_sort Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D
author Palczewski, Raphael Henrique
author_facet Palczewski, Raphael Henrique
author_role author
dc.contributor.advisor1.fl_str_mv Togashi, Adriane Yaeko
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2205570443795384
dc.contributor.advisor-co1.fl_str_mv Luize, Danielle Shima
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/3315242658841066
dc.contributor.referee1.fl_str_mv Togashi, Adriane Yaeko
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/2205570443795384
dc.contributor.referee2.fl_str_mv Rangel, Ana Lúcia Carrinho Ayroza
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/1438147088984375
dc.contributor.referee3.fl_str_mv Fujimaki, Mitsue
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/2807927162629148
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/3660874694838754
dc.contributor.author.fl_str_mv Palczewski, Raphael Henrique
contributor_str_mv Togashi, Adriane Yaeko
Luize, Danielle Shima
Togashi, Adriane Yaeko
Rangel, Ana Lúcia Carrinho Ayroza
Fujimaki, Mitsue
dc.subject.por.fl_str_mv Vitamina D
Densidade óssea
Remodelação óssea
Suplementação
topic Vitamina D
Densidade óssea
Remodelação óssea
Suplementação
Vitamin D
Bone density
Bone remodeling
Supplementation
CIENCIAS DA SAUDE::ODONTOLOGIA
dc.subject.eng.fl_str_mv Vitamin D
Bone density
Bone remodeling
Supplementation
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::ODONTOLOGIA
description The plasma vitamin D plays a key role in regulating calcium and phosphate homeostasis with activity on liver, intestine, kidney and bone. Calcium and phosphate obtained through the diet, are environmental elements necessary together with Vitamin D to determine whether 1,25-hydroxyvitamin D exerts an anabolic or catabolic effect on bone mineral appearance. This research was conducted to evaluate the effect of vitamin D3 supplementation exerts on the bone density of the femur and mice jaw. mice were used C57BL / 6 males and females, were divided into two groups: 1) control group (n = 24) and 2) experimental group (n = 24) - subject to systemic administration of vitamin D by means of vitamin D3 gavage (VITD) at a concentration of 10,000 IU for week. After 4 weeks of administration of Vitamin D was performed surgery for placement of titanium implants in the lateral region of the mandible and animals were sacrificed within 7 and 21 days after implant placement. Histomorphometric analyzes were carried out in the regions of femoral metaphysis and jaw through digital LAZ v4.2 and radiographic program and analyzed by BA-DDX program through digital periapical, where it was verified that there was an increase in bone density among the groups through the trabecular pixel count. For the statistical analysis were applied Anova and Bonferroni multiple correlation and Kruskal Wallis test. The results of histomorphometric analysis showed no difference in bone structures (trabecular and marrow spaces) in the jaw evaluated by vitamin D3 supplementation at 7 and 21 days of healing. The results of radiographic however, showed that the jaw was no increase in bone density in the supplemented group compared to the control group (p <0.05), without however, differences in the same group over time (7 and 21 days). The femur there was no difference between control and experimental groups over time, in the metaphyseal region, however, in the diaphyseal region noticed an increase in the number of pixels trabecular in the supplemented group compared to the control group (p = 0.001). It can be concluded that by the structures evaluated in the histomorphometric analysis, supplementation with vitamin D3 had no effect on bone parameters of the jaw and femur, but the radiographic analysis showed an increase in bone density between the control and experimental groups in the jaw to around the implant and femoral diaphysis.
publishDate 2016
dc.date.issued.fl_str_mv 2016-04-04
dc.date.accessioned.fl_str_mv 2017-08-29T14:15:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
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dc.identifier.citation.fl_str_mv PALCZEWSKI, Raphael Henrique. Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D. 2016. 54 f. Dissertação ( Mestrado em Odontologia) - Universidade Estadual do Oeste do Paraná, Cascavel, 2016.
dc.identifier.uri.fl_str_mv http://tede.unioeste.br/handle/tede/2952
identifier_str_mv PALCZEWSKI, Raphael Henrique. Caracterização histomorfométrica e radiográfica do tecido ósseo da mandíbula e fêmur de camundongos suplementados com vitamina D. 2016. 54 f. Dissertação ( Mestrado em Odontologia) - Universidade Estadual do Oeste do Paraná, Cascavel, 2016.
url http://tede.unioeste.br/handle/tede/2952
dc.language.iso.fl_str_mv por
language por
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dc.relation.confidence.fl_str_mv 600
600
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dc.relation.cnpq.fl_str_mv -2070498469879244349
dc.relation.sponsorship.fl_str_mv 2075167498588264571
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by-nc-nd/4.0/
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dc.publisher.none.fl_str_mv Universidade Estadual do Oeste do Paraná
Cascavel
dc.publisher.program.fl_str_mv Programa de Pós-Graduação em Odontologia
dc.publisher.initials.fl_str_mv UNIOESTE
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Centro de Ciências Biológicas e da Saúde
publisher.none.fl_str_mv Universidade Estadual do Oeste do Paraná
Cascavel
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