Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNIOESTE |
Texto Completo: | http://tede.unioeste.br/handle/tede/4091 |
Resumo: | Triclosan (TCS) is an antimicrobial agent widely used in manufactured products, especially in personal care and oral hygiene products. Studies prove that it changes the homeostasis of several organisms and is therefore considered an endocrine disruptor. Thus, the aim of the present study was to evaluate the effects of maternal exposure to TCS during pregnancy and lactation in the uterine morphology of the rat offspring. For this, thirty-two pregnant rats were divided into 4 groups of 8, treated once daily orally, during pregnancy and lactation, as follows: Group I - control (GI): corn oil; Group II (GII): TCS diluted in corn oil at a dose of 75 mg/kg/day; Group III (GIII): TCS diluted in corn oil at a dose of 150 mg/kg/day; Group IV (GIV): TCS diluted in corn oil at a dose of 300 mg/kg/day. A female cub of each mother was selected, and at 90 days the pups were euthanized for weighing and collection of the uterus for histomorphometric analysis. The results showed that the mean litter weight was minor in all the groups treated with TCS, when compared to control. The offspring of all groups exposed to TCS presented estrous cycle dysregulation, compared to control. Analysis of the uterine histological structure demonstrated that all layers of the uterus were affected by the administration of TCS, and the morphometric analysis showed increased uterine layers in the treated groups. The leukocyte count showed an increase in inflammatory infiltrate in the groups of 150 and 300 mg of TCS, in comparison to the other groups. It is concluded that maternal exposure to TCS, during pregnancy and lactation, causes a decrease in the mean weight of the litter, deregulates the estrous cycle and causes a change in the uterine structure of the offspring. |
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Amorim, João Paulo de Arrudahttp://lattes.cnpq.br/4100033010756626Busato, Mauro Carlos Agnerhttp://lattes.cnpq.br/1189765186576000Silva , Sóstenez Alexandre Vessaro dahttp://lattes.cnpq.br/4259081046368684Amorim , Elaine Manoela Portohttp://lattes.cnpq.br/8259986555600622http://lattes.cnpq.br/8404427718991204Bitencourt, Guilherme2019-02-14T14:00:18Z2018-03-19BITENCOURT, Guilherme. Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato. 2018. 47 f.. Dissertação( Mestrado em Odontologia) - Universidade Estadual do Oeste do Paraná, Cascavel, 2018.http://tede.unioeste.br/handle/tede/4091Triclosan (TCS) is an antimicrobial agent widely used in manufactured products, especially in personal care and oral hygiene products. Studies prove that it changes the homeostasis of several organisms and is therefore considered an endocrine disruptor. Thus, the aim of the present study was to evaluate the effects of maternal exposure to TCS during pregnancy and lactation in the uterine morphology of the rat offspring. For this, thirty-two pregnant rats were divided into 4 groups of 8, treated once daily orally, during pregnancy and lactation, as follows: Group I - control (GI): corn oil; Group II (GII): TCS diluted in corn oil at a dose of 75 mg/kg/day; Group III (GIII): TCS diluted in corn oil at a dose of 150 mg/kg/day; Group IV (GIV): TCS diluted in corn oil at a dose of 300 mg/kg/day. A female cub of each mother was selected, and at 90 days the pups were euthanized for weighing and collection of the uterus for histomorphometric analysis. The results showed that the mean litter weight was minor in all the groups treated with TCS, when compared to control. The offspring of all groups exposed to TCS presented estrous cycle dysregulation, compared to control. Analysis of the uterine histological structure demonstrated that all layers of the uterus were affected by the administration of TCS, and the morphometric analysis showed increased uterine layers in the treated groups. The leukocyte count showed an increase in inflammatory infiltrate in the groups of 150 and 300 mg of TCS, in comparison to the other groups. It is concluded that maternal exposure to TCS, during pregnancy and lactation, causes a decrease in the mean weight of the litter, deregulates the estrous cycle and causes a change in the uterine structure of the offspring.O Triclosan (TCS) é um agente antimicrobiano amplamente utilizado em produtos industrializados, especialmente de cuidado pessoal e higiene oral. Estudos comprovam que ele altera a homeostase de diversos organismos, sendo, portanto, considerado um desregulador endócrino. Assim, o objetivo da presente pesquisa foi avaliar os efeitos decorrentes da exposição materna ao TCS durante a prenhez e lactação na morfofisiologia uterina da prole de ratas. Para tanto, trinta e duas ratas prenhes foram divididas em 4 grupos de 8 ratas cada, tratadas uma vez ao dia, por via oral, durante a prenhez e lactação, da seguinte forma: Grupo I – controle (GI): somente óleo de milho; Grupo II (GII): TCS diluído em óleo de milho, na dose de 75 mg/kg/dia; Grupo III (GIII): TCS diluído em óleo de milho, na dose de 150 mg/kg/dia; Grupo IV (GIV): TCS diluído em óleo de milho, na dose de 300 mg/kg/dia. Um filhote do sexo feminino de cada mãe foi selecionado, e aos 90 dias, os filhotes foram eutanasiados, para pesagem e coleta do útero para análise histomorfométrica. Os resultados mostraram que o peso médio da ninhada foi significativamente menor em todos os grupos tratados com TCS, quando comparados ao controle. A prole de todos os grupos expostos ao TCS apresentou desregulação do ciclo estral, comparados ao controle. A análise da estrutura histológica uterina demonstrou que todas as camadas do útero foram afetadas pela administração de TCS, e a análise morfométrica mostrou aumento de todas as camadas uterinas nos grupos tratados. A contagem de leucócitos apresentou aumento do infiltrado inflamatório nos grupos de 150 e 300 mg de TCS, em comparação aos demais grupos. Conclui-se que a exposição materna ao TCS, durante a prenhez e lactação, provoca diminuição do peso médio da ninhada, desregula o ciclo estral e causa alteração da estrutura uterina da prole.Submitted by Edineia Teixeira (edineia.teixeira@unioeste.br) on 2019-02-14T14:00:18Z No. of bitstreams: 2 Guilherme_ Bitencourt_2018.pdf: 1209957 bytes, checksum: 74cdbd4c67f442252f8ba1c43dd988aa (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2019-02-14T14:00:18Z (GMT). No. of bitstreams: 2 Guilherme_ Bitencourt_2018.pdf: 1209957 bytes, checksum: 74cdbd4c67f442252f8ba1c43dd988aa (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2028-03-19Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfpor6588633818200016417500Universidade Estadual do Oeste do ParanáCascavelPrograma de Pós-Graduação em OdontologiaUNIOESTEBrasilCentro de Ciências Biológicas e da Saúdehttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessTriclosanDisruptoresEndócrinosÚteroRatosTriclosanEndocrineDisruptorsUerusRatsCIENCIAS DA SAUDE::ODONTOLOGIACaracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de ratoCharacterization of the effects of maternal exposure to Triclosan during pregnancy and lactation on uterine morphology of female offspringinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis-80965548187336651646006006006001458059979463924370-20704984698792443492075167498588264571reponame:Biblioteca Digital de Teses e Dissertações do UNIOESTEinstname:Universidade Estadual do Oeste do Paraná (UNIOESTE)instacron:UNIOESTEORIGINALGuilherme_ Bitencourt_2018.pdfGuilherme_ Bitencourt_2018.pdfapplication/pdf1209957http://tede.unioeste.br:8080/tede/bitstream/tede/4091/5/Guilherme_+Bitencourt_2018.pdf74cdbd4c67f442252f8ba1c43dd988aaMD55CC-LICENSElicense_urllicense_urltext/plain; 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dc.title.por.fl_str_mv |
Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato |
dc.title.alternative.eng.fl_str_mv |
Characterization of the effects of maternal exposure to Triclosan during pregnancy and lactation on uterine morphology of female offspring |
title |
Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato |
spellingShingle |
Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato Bitencourt, Guilherme Triclosan Disruptores Endócrinos Útero Ratos Triclosan Endocrine Disruptors Uerus Rats CIENCIAS DA SAUDE::ODONTOLOGIA |
title_short |
Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato |
title_full |
Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato |
title_fullStr |
Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato |
title_full_unstemmed |
Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato |
title_sort |
Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato |
author |
Bitencourt, Guilherme |
author_facet |
Bitencourt, Guilherme |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Amorim, João Paulo de Arruda |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/4100033010756626 |
dc.contributor.referee1.fl_str_mv |
Busato, Mauro Carlos Agner |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/1189765186576000 |
dc.contributor.referee2.fl_str_mv |
Silva , Sóstenez Alexandre Vessaro da |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/4259081046368684 |
dc.contributor.referee3.fl_str_mv |
Amorim , Elaine Manoela Porto |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/8259986555600622 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/8404427718991204 |
dc.contributor.author.fl_str_mv |
Bitencourt, Guilherme |
contributor_str_mv |
Amorim, João Paulo de Arruda Busato, Mauro Carlos Agner Silva , Sóstenez Alexandre Vessaro da Amorim , Elaine Manoela Porto |
dc.subject.por.fl_str_mv |
Triclosan Disruptores Endócrinos Útero Ratos |
topic |
Triclosan Disruptores Endócrinos Útero Ratos Triclosan Endocrine Disruptors Uerus Rats CIENCIAS DA SAUDE::ODONTOLOGIA |
dc.subject.eng.fl_str_mv |
Triclosan Endocrine Disruptors Uerus Rats |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::ODONTOLOGIA |
description |
Triclosan (TCS) is an antimicrobial agent widely used in manufactured products, especially in personal care and oral hygiene products. Studies prove that it changes the homeostasis of several organisms and is therefore considered an endocrine disruptor. Thus, the aim of the present study was to evaluate the effects of maternal exposure to TCS during pregnancy and lactation in the uterine morphology of the rat offspring. For this, thirty-two pregnant rats were divided into 4 groups of 8, treated once daily orally, during pregnancy and lactation, as follows: Group I - control (GI): corn oil; Group II (GII): TCS diluted in corn oil at a dose of 75 mg/kg/day; Group III (GIII): TCS diluted in corn oil at a dose of 150 mg/kg/day; Group IV (GIV): TCS diluted in corn oil at a dose of 300 mg/kg/day. A female cub of each mother was selected, and at 90 days the pups were euthanized for weighing and collection of the uterus for histomorphometric analysis. The results showed that the mean litter weight was minor in all the groups treated with TCS, when compared to control. The offspring of all groups exposed to TCS presented estrous cycle dysregulation, compared to control. Analysis of the uterine histological structure demonstrated that all layers of the uterus were affected by the administration of TCS, and the morphometric analysis showed increased uterine layers in the treated groups. The leukocyte count showed an increase in inflammatory infiltrate in the groups of 150 and 300 mg of TCS, in comparison to the other groups. It is concluded that maternal exposure to TCS, during pregnancy and lactation, causes a decrease in the mean weight of the litter, deregulates the estrous cycle and causes a change in the uterine structure of the offspring. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018-03-19 |
dc.date.accessioned.fl_str_mv |
2019-02-14T14:00:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
BITENCOURT, Guilherme. Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato. 2018. 47 f.. Dissertação( Mestrado em Odontologia) - Universidade Estadual do Oeste do Paraná, Cascavel, 2018. |
dc.identifier.uri.fl_str_mv |
http://tede.unioeste.br/handle/tede/4091 |
identifier_str_mv |
BITENCOURT, Guilherme. Caracterização dos efeitos da exposição materna ao Triclosan, durante a prenhez e lactação, na morfofisiologia uterina da prole feminina de rato. 2018. 47 f.. Dissertação( Mestrado em Odontologia) - Universidade Estadual do Oeste do Paraná, Cascavel, 2018. |
url |
http://tede.unioeste.br/handle/tede/4091 |
dc.language.iso.fl_str_mv |
por |
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por |
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600 600 600 600 |
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1458059979463924370 |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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Universidade Estadual do Oeste do Paraná Cascavel |
dc.publisher.program.fl_str_mv |
Programa de Pós-Graduação em Odontologia |
dc.publisher.initials.fl_str_mv |
UNIOESTE |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Centro de Ciências Biológicas e da Saúde |
publisher.none.fl_str_mv |
Universidade Estadual do Oeste do Paraná Cascavel |
dc.source.none.fl_str_mv |
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