Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática

Detalhes bibliográficos
Autor(a) principal: Friedrich, Jennifer Alexandra Castanho Vieira
Data de Publicação: 2020
Tipo de documento: Dissertação
Idioma: por
Título da fonte: Biblioteca Digital de Teses e Dissertações do UNIOESTE
Texto Completo: http://tede.unioeste.br/handle/tede/5693
Resumo: Probiotics affect the intestinal microbiota, stimulating immunological and nonimmunological mechanisms of the intestinal mucosa through antagonism with a potential pathogen. In autoimmune diseases, the immune system attacks and harms the body itself, and many of these diseases affect the gastrointestinal system. The objective of this work was to evaluate the use of probiotic bacteria in the treatment of autoimmune diseases through a systematic review of in vivo studies conducted in patients with autoimmune diseases of the gastrointestinal system (autoimmune gastritis; inflammatory bowel diseases: Crohn's disease and ulcerative colitis; celiac disease and autoimmune enteropathy). Thus, a systematic review was carried out in the following databases: Pubmed, Cochrane Library, Scopus and Web of Science using advanced search strategies. Data management was performed using Microsoft Office Excel and EndNote. 2868 articles were retrieved, and after screening duplicate articles and evaluating the abstracts regarding the eligibility criteria, 47 articles were selected for the development of the systematic review. Among the selected articles, the majority were related to ulcerative colitis, with 81.08% with a beneficial outcome regarding the use of probiotics, whereas with Crohn's disease, only 55.56% had a positive outcome. Regarding celiac disease, 85.71% demonstrate a beneficial effect in the use of probiotics. No articles were selected regarding autoimmune gastritis and autoimmune enteropathy. After evaluating the articles, it is suggested that the intervention with probiotics has benefits in the treatment of celiac disease along with a gluten-free diet. Regarding IBDs, it is suggested that the ingestion of probiotics also has benefits in patients with ulcerative colitis, however, it is not possible to conclude the beneficial effect in the use of probiotics in Crohn's disease.
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spelling Fariña, Luciana Oliveira dehttp://lattes.cnpq.br/2043990245681647Fariña, Luciana Oliveira dehttp://lattes.cnpq.br/2043990245681647Cruz, Adriano Gomes dahttp://lattes.cnpq.br/2750728168418179Schneider, Sara Cristina Sagaehttp://lattes.cnpq.br/4952215583363653http://lattes.cnpq.br/7175608178202718Friedrich, Jennifer Alexandra Castanho Vieira2021-11-29T14:10:22Z2020-11-30FRIEDRICH, Jennifer Alexandra Castanho Vieira. Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática. 2020. 81 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel - PR.http://tede.unioeste.br/handle/tede/5693Probiotics affect the intestinal microbiota, stimulating immunological and nonimmunological mechanisms of the intestinal mucosa through antagonism with a potential pathogen. In autoimmune diseases, the immune system attacks and harms the body itself, and many of these diseases affect the gastrointestinal system. The objective of this work was to evaluate the use of probiotic bacteria in the treatment of autoimmune diseases through a systematic review of in vivo studies conducted in patients with autoimmune diseases of the gastrointestinal system (autoimmune gastritis; inflammatory bowel diseases: Crohn's disease and ulcerative colitis; celiac disease and autoimmune enteropathy). Thus, a systematic review was carried out in the following databases: Pubmed, Cochrane Library, Scopus and Web of Science using advanced search strategies. Data management was performed using Microsoft Office Excel and EndNote. 2868 articles were retrieved, and after screening duplicate articles and evaluating the abstracts regarding the eligibility criteria, 47 articles were selected for the development of the systematic review. Among the selected articles, the majority were related to ulcerative colitis, with 81.08% with a beneficial outcome regarding the use of probiotics, whereas with Crohn's disease, only 55.56% had a positive outcome. Regarding celiac disease, 85.71% demonstrate a beneficial effect in the use of probiotics. No articles were selected regarding autoimmune gastritis and autoimmune enteropathy. After evaluating the articles, it is suggested that the intervention with probiotics has benefits in the treatment of celiac disease along with a gluten-free diet. Regarding IBDs, it is suggested that the ingestion of probiotics also has benefits in patients with ulcerative colitis, however, it is not possible to conclude the beneficial effect in the use of probiotics in Crohn's disease.Os probióticos afetam beneficamente a microbiota intestinal, estimulando os mecanismos imunológicos e não imunológicos da mucosa intestinal, por meio de um antagonismo com os patógenos potenciais. Nas doenças autoimunes, o sistema imunológico ataca e prejudica o próprio organismo, sendo que muitas dessas doenças afetam o sistema gastrointestinal. O objetivo deste trabalho foi avaliar o uso de bactérias probióticas no tratamento de doenças autoimunes, por meio de uma revisão sistemática em estudos in vivo, conduzidos em pacientes portadores de doenças autoimunes do sistema gastrointestinal (gastrite autoimune; doenças inflamatórias intestinais: doença de Crohn e colite ulcerativa; doença celíaca e enteropatia autoimune). Dessa forma, foi realizada uma revisão sistemática nas seguintes bases de dados: Pubmed, Cochrane Library, Scopus e Web of Science, utilizando estratégias avançadas de busca. O gerenciamento dos dados foi feito com a utilização dos programas Microsoft Office Excel e EndNote. Foram recuperados 2868 artigos, sendo que, após a triagem de artigos duplicados e avaliação dos resumos quanto aos critérios de elegibilidade, foram selecionados 47 artigos para o desenvolvimento da revisão sistemática. Dentre os artigos selecionados, a grande maioria foi referente à colite ulcerativa, apresentando 81,08 % com desfecho benéfico quanto ao uso de probióticos; já referente à doença de Crohn, apenas 55,56 % apresentaram desfecho positivo. Referente à doença celíaca, 85,71 % demonstraram efeito benéfico no uso de probióticos. Não foram selecionados artigos referentes à gastrite autoimune e nem à enteropatia autoimune. Após avaliação dos artigos, sugere-se que a intervenção com probióticos apresente benefícios no tratamento da doença celíaca, juntamente à dieta livre de glúten. Já referente às Doenças inflamatórias intestinais (DIIs), sugere-se que a ingestão de probióticos também apresente benefícios em pacientes com colite ulcerativa. No entanto, não é possível concluir o efeito benéfico no uso de probióticos na doença de Crohn.Submitted by Neusa Fagundes (neusa.fagundes@unioeste.br) on 2021-11-29T14:10:22Z No. of bitstreams: 2 Jennifer_Friedrich2020.pdf: 1952149 bytes, checksum: a79aa08c84e715eef9299d4daf35daa1 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2021-11-29T14:10:22Z (GMT). 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dc.title.por.fl_str_mv Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática
dc.title.alternative.eng.fl_str_mv The use of probiotics in gastrointestinal autoimmune diseases: a systematic review
title Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática
spellingShingle Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática
Friedrich, Jennifer Alexandra Castanho Vieira
Probióticos
Inflamação
Microbiota intestinal
imunomodulação
Probiotics
inflammation
intestinal microbiota
immunomodulation
CIENCIAS DA SAUDE::FARMACIA
title_short Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática
title_full Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática
title_fullStr Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática
title_full_unstemmed Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática
title_sort Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática
author Friedrich, Jennifer Alexandra Castanho Vieira
author_facet Friedrich, Jennifer Alexandra Castanho Vieira
author_role author
dc.contributor.advisor1.fl_str_mv Fariña, Luciana Oliveira de
dc.contributor.advisor1Lattes.fl_str_mv http://lattes.cnpq.br/2043990245681647
dc.contributor.referee1.fl_str_mv Fariña, Luciana Oliveira de
dc.contributor.referee1Lattes.fl_str_mv http://lattes.cnpq.br/2043990245681647
dc.contributor.referee2.fl_str_mv Cruz, Adriano Gomes da
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/2750728168418179
dc.contributor.referee3.fl_str_mv Schneider, Sara Cristina Sagae
dc.contributor.referee3Lattes.fl_str_mv http://lattes.cnpq.br/4952215583363653
dc.contributor.authorLattes.fl_str_mv http://lattes.cnpq.br/7175608178202718
dc.contributor.author.fl_str_mv Friedrich, Jennifer Alexandra Castanho Vieira
contributor_str_mv Fariña, Luciana Oliveira de
Fariña, Luciana Oliveira de
Cruz, Adriano Gomes da
Schneider, Sara Cristina Sagae
dc.subject.por.fl_str_mv Probióticos
Inflamação
Microbiota intestinal
imunomodulação
topic Probióticos
Inflamação
Microbiota intestinal
imunomodulação
Probiotics
inflammation
intestinal microbiota
immunomodulation
CIENCIAS DA SAUDE::FARMACIA
dc.subject.eng.fl_str_mv Probiotics
inflammation
intestinal microbiota
immunomodulation
dc.subject.cnpq.fl_str_mv CIENCIAS DA SAUDE::FARMACIA
description Probiotics affect the intestinal microbiota, stimulating immunological and nonimmunological mechanisms of the intestinal mucosa through antagonism with a potential pathogen. In autoimmune diseases, the immune system attacks and harms the body itself, and many of these diseases affect the gastrointestinal system. The objective of this work was to evaluate the use of probiotic bacteria in the treatment of autoimmune diseases through a systematic review of in vivo studies conducted in patients with autoimmune diseases of the gastrointestinal system (autoimmune gastritis; inflammatory bowel diseases: Crohn's disease and ulcerative colitis; celiac disease and autoimmune enteropathy). Thus, a systematic review was carried out in the following databases: Pubmed, Cochrane Library, Scopus and Web of Science using advanced search strategies. Data management was performed using Microsoft Office Excel and EndNote. 2868 articles were retrieved, and after screening duplicate articles and evaluating the abstracts regarding the eligibility criteria, 47 articles were selected for the development of the systematic review. Among the selected articles, the majority were related to ulcerative colitis, with 81.08% with a beneficial outcome regarding the use of probiotics, whereas with Crohn's disease, only 55.56% had a positive outcome. Regarding celiac disease, 85.71% demonstrate a beneficial effect in the use of probiotics. No articles were selected regarding autoimmune gastritis and autoimmune enteropathy. After evaluating the articles, it is suggested that the intervention with probiotics has benefits in the treatment of celiac disease along with a gluten-free diet. Regarding IBDs, it is suggested that the ingestion of probiotics also has benefits in patients with ulcerative colitis, however, it is not possible to conclude the beneficial effect in the use of probiotics in Crohn's disease.
publishDate 2020
dc.date.issued.fl_str_mv 2020-11-30
dc.date.accessioned.fl_str_mv 2021-11-29T14:10:22Z
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dc.identifier.citation.fl_str_mv FRIEDRICH, Jennifer Alexandra Castanho Vieira. Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática. 2020. 81 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel - PR.
dc.identifier.uri.fl_str_mv http://tede.unioeste.br/handle/tede/5693
identifier_str_mv FRIEDRICH, Jennifer Alexandra Castanho Vieira. Uso de probióticos em doenças autoimunes gastrointestinais: uma revisão sistemática. 2020. 81 f. Dissertação (Mestrado em Ciências Farmacêuticas) - Universidade Estadual do Oeste do Paraná, Cascavel - PR.
url http://tede.unioeste.br/handle/tede/5693
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