Bacteremia caused by Staphylococcus aureus: a fifteen-year analysis of antimicrobial susceptibility in a tertiary hospital in Brazil

• Autor(a) principal: Duarte, Felipe Crepaldi
• Data de Publicação: 2018
• Outros Autores: Danelli, Tiago, Ribeiro, Maria Alice Galvão, Perugini, Luis Felipe, Vespero, Eliana Carolina, Carrara-Marroni, Floristher Elaine, Pelisson, Marsileni, Yamauchi, Lucy Megumi, Yamada-Ogatta, Sueli Fumie, Eches Perugini, Marcia Regina
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista de Epidemiologia e Controle de Infecção
• Texto Completo: https://online.unisc.br/seer/index.php/epidemiologia/article/view/11245

Background and Objective: Bloodstream infections caused by Staphylococcus aureus are a major cause of morbidity and mortality worldwide. Treatment of S. aureus infections is complex, in part, due to the high prevalence of antimicrobial resistance. Understanding the epidemiology and resistance patterns of this microorganism is a critical point for the proper empirical prescription of antimicrobials. Thus, this study aimed to evaluate the evolution of antimicrobial resistance of S. aureus in a period of fifteen years. Methods: Antimicrobial susceptibility profiles was determined for cefoxitin (30μg), penicillin (10 U), erythromycin (15 μg), clindamycin (2 μg), gentamycin (10 μg),ciprofloxacin (5μg), sulfamethoxazole-trimethoprim (23.75/1.25 μg), rifampicin (5 μg), and tetracycline (30μg) in 720 S. aureus isolated from blood cultures in a tertiary hospital in southern Brazil were analyzed. Sensiblity values was determined according to Clinical Laboratory Standards Institute (CLSI, 2018).The data were obtained from the AGTA Healthcare Information System, LABHOS ® module. Results: The mean frequency of methicillin-resistant S. aureus was 43.74%. Except for penicillin, there was a significant variation of resistance for all antimicrobials in the period evaluated (ρ