Association between severity score, inflammatory levels and DNA damage in intensive care patients
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Revista de Epidemiologia e Controle de Infecção |
Texto Completo: | https://online.unisc.br/seer/index.php/epidemiologia/article/view/14110 |
Resumo: | Background and Objectives: The Intensive Care Unit (ICU) is responsible for the treatment of critical patients and monitoring it continuously can improve the quality of care provided. This study aims to associate the Simplified Acute Physiology Score (SAPS 3) with inflammatory levels and genomic damage in patients admitted to the ICU of a hospital in Vale do Taquari, Rio Grande do Sul, Brazil. Methods: This is a cross-sectional study conducted with 22 patients from an adult ICU,between January and June 2016. The SAPS 3 was scored by the medical staff at the admission of patients and blood samples were obtained after 24 and 72 hours of hospitalization for C-Reactive Protein (CRP) dosing and DNA damage. Results: The SAPS 3 score was not associated with 24-and 72-hours CRP. However, the SAPS 3 score was significantly associated with the index and frequency of DNA damage, only after 72 hours of hospitalization. Conclusion: The severity score was not associated with CRP levels, but with DNA damage only after 72 hours of admission. Critical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage. |
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Revista de Epidemiologia e Controle de Infecção |
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Association between severity score, inflammatory levels and DNA damage in intensive care patientsCritical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage.Background and Objectives: The Intensive Care Unit (ICU) is responsible for the treatment of critical patients and monitoring it continuously can improve the quality of care provided. This study aims to associate the Simplified Acute Physiology Score (SAPS 3) with inflammatory levels and genomic damage in patients admitted to the ICU of a hospital in Vale do Taquari, Rio Grande do Sul, Brazil. Methods: This is a cross-sectional study conducted with 22 patients from an adult ICU,between January and June 2016. The SAPS 3 was scored by the medical staff at the admission of patients and blood samples were obtained after 24 and 72 hours of hospitalization for C-Reactive Protein (CRP) dosing and DNA damage. Results: The SAPS 3 score was not associated with 24-and 72-hours CRP. However, the SAPS 3 score was significantly associated with the index and frequency of DNA damage, only after 72 hours of hospitalization. Conclusion: The severity score was not associated with CRP levels, but with DNA damage only after 72 hours of admission. Critical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage.Unisc2020-07-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/1411010.17058/jeic.v10i3.14110Revista de Epidemiologia e Controle de Infecção; Vol. 10 No. 3 (2020)Revista de Epidemiologia e Controle de Infecção; v. 10 n. 3 (2020)2238-3360reponame:Revista de Epidemiologia e Controle de Infecçãoinstname:Universidade de Santa Cruz do Sul (UNISC)instacron:UNISCengporhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/14110/9272https://online.unisc.br/seer/index.php/epidemiologia/article/view/14110/9278Copyright (c) 2020 Andriela Vieceli Mattje, Patrícia Molz, Caio Fernando de Oliveira, Diene da Silva Schlickmann, Jane Dagmar Pollo Renner, Leo Kraether Neto, Daniel Prá, Silvia Isabel Rech Frankeinfo:eu-repo/semantics/openAccessMattje, Andriela VieceliMolz, Patríciade Oliveira, Caio FernandoSchlickmann, Diene da SilvaRenner, Jane Dagmar PolloKraether Neto, LeoPrá, DanielFranke, Silvia Isabel Rech2022-08-08T12:58:04Zoai:ojs.online.unisc.br:article/14110Revistahttps://online.unisc.br/seer/index.php/epidemiologia/indexONGhttp://online.unisc.br/seer/index.php/epidemiologia/oai||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com2238-33602238-3360opendoar:2022-08-08T12:58:04Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC)false |
dc.title.none.fl_str_mv |
Association between severity score, inflammatory levels and DNA damage in intensive care patients |
title |
Association between severity score, inflammatory levels and DNA damage in intensive care patients |
spellingShingle |
Association between severity score, inflammatory levels and DNA damage in intensive care patients Mattje, Andriela Vieceli Critical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage. |
title_short |
Association between severity score, inflammatory levels and DNA damage in intensive care patients |
title_full |
Association between severity score, inflammatory levels and DNA damage in intensive care patients |
title_fullStr |
Association between severity score, inflammatory levels and DNA damage in intensive care patients |
title_full_unstemmed |
Association between severity score, inflammatory levels and DNA damage in intensive care patients |
title_sort |
Association between severity score, inflammatory levels and DNA damage in intensive care patients |
author |
Mattje, Andriela Vieceli |
author_facet |
Mattje, Andriela Vieceli Molz, Patrícia de Oliveira, Caio Fernando Schlickmann, Diene da Silva Renner, Jane Dagmar Pollo Kraether Neto, Leo Prá, Daniel Franke, Silvia Isabel Rech |
author_role |
author |
author2 |
Molz, Patrícia de Oliveira, Caio Fernando Schlickmann, Diene da Silva Renner, Jane Dagmar Pollo Kraether Neto, Leo Prá, Daniel Franke, Silvia Isabel Rech |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Mattje, Andriela Vieceli Molz, Patrícia de Oliveira, Caio Fernando Schlickmann, Diene da Silva Renner, Jane Dagmar Pollo Kraether Neto, Leo Prá, Daniel Franke, Silvia Isabel Rech |
dc.subject.por.fl_str_mv |
Critical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage. |
topic |
Critical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage. |
description |
Background and Objectives: The Intensive Care Unit (ICU) is responsible for the treatment of critical patients and monitoring it continuously can improve the quality of care provided. This study aims to associate the Simplified Acute Physiology Score (SAPS 3) with inflammatory levels and genomic damage in patients admitted to the ICU of a hospital in Vale do Taquari, Rio Grande do Sul, Brazil. Methods: This is a cross-sectional study conducted with 22 patients from an adult ICU,between January and June 2016. The SAPS 3 was scored by the medical staff at the admission of patients and blood samples were obtained after 24 and 72 hours of hospitalization for C-Reactive Protein (CRP) dosing and DNA damage. Results: The SAPS 3 score was not associated with 24-and 72-hours CRP. However, the SAPS 3 score was significantly associated with the index and frequency of DNA damage, only after 72 hours of hospitalization. Conclusion: The severity score was not associated with CRP levels, but with DNA damage only after 72 hours of admission. Critical Care. Simplified Acute Physiology Score. Polymerase Chain Reaction. DNA damage. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-07-07 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/14110 10.17058/jeic.v10i3.14110 |
url |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/14110 |
identifier_str_mv |
10.17058/jeic.v10i3.14110 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/14110/9272 https://online.unisc.br/seer/index.php/epidemiologia/article/view/14110/9278 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Unisc |
publisher.none.fl_str_mv |
Unisc |
dc.source.none.fl_str_mv |
Revista de Epidemiologia e Controle de Infecção; Vol. 10 No. 3 (2020) Revista de Epidemiologia e Controle de Infecção; v. 10 n. 3 (2020) 2238-3360 reponame:Revista de Epidemiologia e Controle de Infecção instname:Universidade de Santa Cruz do Sul (UNISC) instacron:UNISC |
instname_str |
Universidade de Santa Cruz do Sul (UNISC) |
instacron_str |
UNISC |
institution |
UNISC |
reponame_str |
Revista de Epidemiologia e Controle de Infecção |
collection |
Revista de Epidemiologia e Controle de Infecção |
repository.name.fl_str_mv |
Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC) |
repository.mail.fl_str_mv |
||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com |
_version_ |
1800218811762212864 |