NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Epidemiologia e Controle de Infecção |
Texto Completo: | https://online.unisc.br/seer/index.php/epidemiologia/article/view/4821 |
Resumo: | Background and Objectives: The increased incidence of multiresistant microorganisms allied with the emergence of new mechanisms of bacterial resistance has ted treatment-related health care infections. Staphylococcus aureus has shown therapeutic limitations due to high prevalence of isolates resistant to methicillin (MRSA). The constant evolution of microorganisms in relation to antimicrobial susceptibility and rapid dissemintaion requires the introduction of new drugs in clinical practice to control infections caused by multiresistant microorganisms. In recent years, it has developed a limited number of new antimicrobial agents, among them are the 5th generation cephalosporins, ceftobiprole and ceftarolina, which have proven effective against MRSA isolates. The aim of this study was to review the literature about the characteristics and evolution of resistance in S. aureus, and about new antimicrobials used in clinical practice, featuring the main advantages and limitations of current treatment options. Methods: A literature review was performed in the MEDLINE and Scielo with papers published until the year 2014 survey was grouped according to the thematic focus following: cephalosporins, methicillin-resistant Staphylococcus aureus, combined modality therapy. Results: This study included nine scientific papers published in national and international journals for review. The articles included in this review were selected according to the information that is desired to be obtained, as follows regarding the use of antimicrobials in new anti-MRSA therapy, the main features and the advantages and limitations of current alternatives vailable. Conclusion: It is concluded that cephalosporins 5th generation is a viable therapeutic option due to the satisfactory results reported in different studies to the treatment of infections, with each hospital, determine and adapt in their clinical practice, the use of new options treatment of MRSA infections. Keywords: Cephalosporins. Methicillin-resistant Staphylococcus aureus. Combined Modality Therapy. |
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NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA)Novas cefalosporinas como alternativa no tratamento de infecções por Staphylococcus aureus resistente à meticilina (MRSA)Background and Objectives: The increased incidence of multiresistant microorganisms allied with the emergence of new mechanisms of bacterial resistance has ted treatment-related health care infections. Staphylococcus aureus has shown therapeutic limitations due to high prevalence of isolates resistant to methicillin (MRSA). The constant evolution of microorganisms in relation to antimicrobial susceptibility and rapid dissemintaion requires the introduction of new drugs in clinical practice to control infections caused by multiresistant microorganisms. In recent years, it has developed a limited number of new antimicrobial agents, among them are the 5th generation cephalosporins, ceftobiprole and ceftarolina, which have proven effective against MRSA isolates. The aim of this study was to review the literature about the characteristics and evolution of resistance in S. aureus, and about new antimicrobials used in clinical practice, featuring the main advantages and limitations of current treatment options. Methods: A literature review was performed in the MEDLINE and Scielo with papers published until the year 2014 survey was grouped according to the thematic focus following: cephalosporins, methicillin-resistant Staphylococcus aureus, combined modality therapy. Results: This study included nine scientific papers published in national and international journals for review. The articles included in this review were selected according to the information that is desired to be obtained, as follows regarding the use of antimicrobials in new anti-MRSA therapy, the main features and the advantages and limitations of current alternatives vailable. Conclusion: It is concluded that cephalosporins 5th generation is a viable therapeutic option due to the satisfactory results reported in different studies to the treatment of infections, with each hospital, determine and adapt in their clinical practice, the use of new options treatment of MRSA infections. Keywords: Cephalosporins. Methicillin-resistant Staphylococcus aureus. Combined Modality Therapy.Justificativa e Objetivos: A incidência de microrganismos multirresistentes aliado ao surgimento de novos mecanismos de resistência bacteriana dificultam o tratamento de infecções. Staphylococcus aureus apresentam limitações terapêuticas decorrente de isolados resistentes à meticilina (MRSA). A evolução dos microrganismos em relação à suscetibilidade aos antimicrobianos disponíveis e a rápida disseminação dos mesmos exige a introdução de novas drogas na prática clínica para o controle de infecções. Nos últimos anos, desenvolveu-se um número limitado de novos antimicrobianos, dentre eles estão as cefalosporinas de 5ª geração, ceftarolina e ceftobiprole, que têm se mostrado eficazes contra isolados de MRSA. O objetivo deste estudo foi realizar uma revisão de literatura em relação às características e evolução da resistência em S. aureus, bem como uso de novos antimicrobianos na prática clínica, caracterizando as principais vantagens e limitações das atuais alternativas terapêuticas. Métodos: Foi realizada uma revisão bibliográfica em base de dados virtuais, utilizando como descritores cefalosporinas, Staphylococcus aureus resistente à meticilina e terapia combinada. A busca foi realizada nas bases de dados MEDLINE e Scielo com trabalhos publicados até o mês de julho de 2014. Resultados: Foram incluídos no estudo 9 artigos científicos publicados em periódicos nacionais e internacionais para análise. Foram incluídos os artigos incluídos que discutiam o emprego de novos antimicrobianos na terapia anti-MRSA, as principais características e as vantagens e limitações das atuais alternativas disponíveis. Conclusão: Conclui-se que as cefalosporinas de 5ª geração constituem uma opção terapêutica viável devido aos resultados satisfatórios revelados em diferentes estudos frente ao tratamento de infecções, cabendo a cada hospital, determinar e adaptar na sua prática clínica, o uso das novas opções de tratamento de infecções causadas por MRSA.Unisc2015-04-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/482110.17058/reci.v5i2.4821Revista de Epidemiologia e Controle de Infecção; Vol. 5 No. 2 (2015); 94-99Revista de Epidemiologia e Controle de Infecção; v. 5 n. 2 (2015); 94-992238-3360reponame:Revista de Epidemiologia e Controle de Infecçãoinstname:Universidade de Santa Cruz do Sul (UNISC)instacron:UNISCporhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/4821/5046Batista, Bruna Gerardoninfo:eu-repo/semantics/openAccess2019-01-21T12:55:14Zoai:ojs.online.unisc.br:article/4821Revistahttps://online.unisc.br/seer/index.php/epidemiologia/indexONGhttp://online.unisc.br/seer/index.php/epidemiologia/oai||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com2238-33602238-3360opendoar:2019-01-21T12:55:14Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC)false |
dc.title.none.fl_str_mv |
NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) Novas cefalosporinas como alternativa no tratamento de infecções por Staphylococcus aureus resistente à meticilina (MRSA) |
title |
NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) |
spellingShingle |
NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) Batista, Bruna Gerardon |
title_short |
NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) |
title_full |
NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) |
title_fullStr |
NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) |
title_full_unstemmed |
NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) |
title_sort |
NEW CEPHALOSPORIN AS AN ALTERNATIVE FOR TREATMENT OF INFECTIONS BY METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA) |
author |
Batista, Bruna Gerardon |
author_facet |
Batista, Bruna Gerardon |
author_role |
author |
dc.contributor.author.fl_str_mv |
Batista, Bruna Gerardon |
description |
Background and Objectives: The increased incidence of multiresistant microorganisms allied with the emergence of new mechanisms of bacterial resistance has ted treatment-related health care infections. Staphylococcus aureus has shown therapeutic limitations due to high prevalence of isolates resistant to methicillin (MRSA). The constant evolution of microorganisms in relation to antimicrobial susceptibility and rapid dissemintaion requires the introduction of new drugs in clinical practice to control infections caused by multiresistant microorganisms. In recent years, it has developed a limited number of new antimicrobial agents, among them are the 5th generation cephalosporins, ceftobiprole and ceftarolina, which have proven effective against MRSA isolates. The aim of this study was to review the literature about the characteristics and evolution of resistance in S. aureus, and about new antimicrobials used in clinical practice, featuring the main advantages and limitations of current treatment options. Methods: A literature review was performed in the MEDLINE and Scielo with papers published until the year 2014 survey was grouped according to the thematic focus following: cephalosporins, methicillin-resistant Staphylococcus aureus, combined modality therapy. Results: This study included nine scientific papers published in national and international journals for review. The articles included in this review were selected according to the information that is desired to be obtained, as follows regarding the use of antimicrobials in new anti-MRSA therapy, the main features and the advantages and limitations of current alternatives vailable. Conclusion: It is concluded that cephalosporins 5th generation is a viable therapeutic option due to the satisfactory results reported in different studies to the treatment of infections, with each hospital, determine and adapt in their clinical practice, the use of new options treatment of MRSA infections. Keywords: Cephalosporins. Methicillin-resistant Staphylococcus aureus. Combined Modality Therapy. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-04-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/4821 10.17058/reci.v5i2.4821 |
url |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/4821 |
identifier_str_mv |
10.17058/reci.v5i2.4821 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/4821/5046 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Unisc |
publisher.none.fl_str_mv |
Unisc |
dc.source.none.fl_str_mv |
Revista de Epidemiologia e Controle de Infecção; Vol. 5 No. 2 (2015); 94-99 Revista de Epidemiologia e Controle de Infecção; v. 5 n. 2 (2015); 94-99 2238-3360 reponame:Revista de Epidemiologia e Controle de Infecção instname:Universidade de Santa Cruz do Sul (UNISC) instacron:UNISC |
instname_str |
Universidade de Santa Cruz do Sul (UNISC) |
instacron_str |
UNISC |
institution |
UNISC |
reponame_str |
Revista de Epidemiologia e Controle de Infecção |
collection |
Revista de Epidemiologia e Controle de Infecção |
repository.name.fl_str_mv |
Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC) |
repository.mail.fl_str_mv |
||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com |
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1800218809739509761 |