Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe

Detalhes bibliográficos
Autor(a) principal: Santos, Matheus de Albuquerque
Data de Publicação: 2018
Outros Autores: Rodrigues, Samuel Lucas Calmon, Nascimento, Aécio Lindenberg Figueiredo, Rodrigues, Jamylle Souza, Góes, Marco Aurélio de Oliveira
Tipo de documento: Artigo
Idioma: por
eng
Título da fonte: Revista de Epidemiologia e Controle de Infecção
Texto Completo: https://online.unisc.br/seer/index.php/epidemiologia/article/view/11591
Resumo: Background and Objectives: Visceral Leishmaniasis (VL) is an endemic antropozoonosis in tropical areas that has been showing expansion and global increase in lethality. This work aims to characterize clinical and epidemiological aspects of VL, identifying factors associated with death. Methods: This is an observational epidemiological study, using data from the state database of LV cases residing in the state of Sergipe, notified between 2007 and 2016 at the SINAN (Information System for Notifiable Diseases). Results: 577 confirmed cases of VL were reported, with concentration in the urban area (76.1%), with a general lethality of 12.3%. There was a predominance of males (69.5%), with higher lethality. The highest concentration of cases occurred in the first decade of life (38.5%). The lethality increased every decade from the age of 40, reaching 39.3% in people 60 years of age or older. In both quinquennia (2007 - 2011 and 2012 - 2016), it was observed that the mean incidence rate (MIC) in children under 10 years is similar between both sexes and from that point on, it is always higher in males. The manifestations related to higher lethality were: hemorrhages (30.3%), jaundice (28.1%), infection (26.4%), edema (25.1%) and HIV coinfection (26,9%). Conclusion: Despite being an endemic transmission area of LV, there have been changes in the epidemiological pattern with an increase in the incidence in the population over 40 years, which may reflect the increase in lethality. The identification of this new scenario and the recognition of signs of gravity are very important for its early diagnosis and timely treatment.
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spelling Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of SergipeLeishmaniasis Visceral: Características clínico-epidemiológicas de casos y muertes en el estado de SergipeLeishmaniose Visceral: Características clínico-epidemiológicas de casos e óbitos no estado de SergipeBackground and Objectives: Visceral Leishmaniasis (VL) is an endemic antropozoonosis in tropical areas that has been showing expansion and global increase in lethality. This work aims to characterize clinical and epidemiological aspects of VL, identifying factors associated with death. Methods: This is an observational epidemiological study, using data from the state database of LV cases residing in the state of Sergipe, notified between 2007 and 2016 at the SINAN (Information System for Notifiable Diseases). Results: 577 confirmed cases of VL were reported, with concentration in the urban area (76.1%), with a general lethality of 12.3%. There was a predominance of males (69.5%), with higher lethality. The highest concentration of cases occurred in the first decade of life (38.5%). The lethality increased every decade from the age of 40, reaching 39.3% in people 60 years of age or older. In both quinquennia (2007 - 2011 and 2012 - 2016), it was observed that the mean incidence rate (MIC) in children under 10 years is similar between both sexes and from that point on, it is always higher in males. The manifestations related to higher lethality were: hemorrhages (30.3%), jaundice (28.1%), infection (26.4%), edema (25.1%) and HIV coinfection (26,9%). Conclusion: Despite being an endemic transmission area of LV, there have been changes in the epidemiological pattern with an increase in the incidence in the population over 40 years, which may reflect the increase in lethality. The identification of this new scenario and the recognition of signs of gravity are very important for its early diagnosis and timely treatment.Justificación y Objetivos: La Leishmaniasis Visceral (LV) es una antropozoosis endémica en áreas tropicales que viene demostrando expansión y un aumento global de la letalidad. Este trabajo pretende analizar y caracterizar aspectos clínicos y epidemiológicos de la LV, identificando factores asociados al óbito. Método: Se trata de un estudio epidemiológico observacional, utilizando los datos de la base estadual de los casos de LV residentes en el estado de Sergipe, notificados entre 2007 y 2016 en el SINAN (Sistema de Información de Agravios de Notificación). Resultados: Se notificaron 577 casos confirmados de LV, habiendo concentración en la zona urbana (76,1%), con letalidad general del 12,3%. Se observó predominio en el sexo masculino (69,5%), con mayor letalidad. La mayor concentración de casos ocurrió en la primera década de vida (38,5%). La mortalidad aumentó cada década a partir de los 40 años, llegando al 39,3% en personas de 60 años o más. En ambos quinquenios (2007 - 2011 y 2012 - 2016), se observó que el coeficiente de incidencia medio (CIM) en menores de 10 años es similar entre los dos sexos ya partir de ahí se presenta siempre mayor en el sexo masculino. Las manifestaciones relacionadas con la mayor letalidad fueron: hemorragias (30,3%), ictericia (28,1%), infección (26,4%), edemas (25,1%) y coinfección con VIH (26,9%). Conclusión: Aunque de ser un área de transmisión endémica de LV, se han producido cambios en el patrón epidemiológico con aumento de la incidencia en franjas de la población mayor a 40 años, lo que puede reflejar en el aumento de la letalidad. La identificación de este nuevo escenario y el reconocimiento de señales de gravedad son muy importantes para su diagnóstico precoz y el tratamiento oportuno.Justificativa e Objetivos: A Leishmaniose Visceral (LV) é uma antropozoonose endêmica em áreas tropicais que vem demonstrando expansão e aumento global da letalidade. Este estudo objetiva caracterizar aspectos clínicos e epidemiológicos da LV, identificando fatores associados ao óbito. Métodos: Trata-se de um estudo epidemiológico observacional, utilizando-se os dados da base estadual dos casos de LV residentes no estado de Sergipe, notificados entre 2007 e 2016 no SINAN (Sistema de Informação de Agravos de Notificação). Resultados: Foram notificados 577 casos confirmados de LV, havendo concentração na zona urbana (76,1%), com letalidade geral de 12,3%. Houve predomínio no sexo masculino (69,5%), com maior letalidade. A maior concentração de casos ocorreu na primeira década de vida (38,5%). A letalidade aumentou a cada década a partir dos 40 anos, chegando a 39,3% em pessoas com 60 anos ou mais. Em ambos os quinquênios (2007 – 2011 e 2012 – 2016), observou-se que o coeficiente de incidência médio (CIM) em menores de 10 anos é semelhante entre os dois sexos e a partir daí apresenta-se sempre maior no sexo masculino. As manifestações relacionadas a maior letalidade foram: hemorragias (30,3%), icterícia (28,1%), infecção (26,4%), edemas (25,1%) e a coinfecção com HIV (26,9%). Conclusão: Apesar de ser uma área de transmissão endêmica de LV, tem ocorrido mudanças no padrão epidemiológico com aumento da incidência em faixas da população maior que 40 anos, o que pode refletir no aumento da letalidade. A identificação desse novo cenário e o reconhecimento de sinais de gravidade são muito importantes para seu diagnóstico precoce e tratamento oportuno.Unisc2018-10-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/1159110.17058/reci.v8i4.11591Revista de Epidemiologia e Controle de Infecção; Vol. 8 No. 4 (2018); 428-434Revista de Epidemiologia e Controle de Infecção; v. 8 n. 4 (2018); 428-4342238-3360reponame:Revista de Epidemiologia e Controle de Infecçãoinstname:Universidade de Santa Cruz do Sul (UNISC)instacron:UNISCporenghttps://online.unisc.br/seer/index.php/epidemiologia/article/view/11591/7623https://online.unisc.br/seer/index.php/epidemiologia/article/view/11591/7815Copyright (c) 2018 Marco Aurélio de Oliveira Góesinfo:eu-repo/semantics/openAccessSantos, Matheus de AlbuquerqueRodrigues, Samuel Lucas CalmonNascimento, Aécio Lindenberg FigueiredoRodrigues, Jamylle SouzaGóes, Marco Aurélio de Oliveira2019-04-01T12:52:45Zoai:ojs.online.unisc.br:article/11591Revistahttps://online.unisc.br/seer/index.php/epidemiologia/indexONGhttp://online.unisc.br/seer/index.php/epidemiologia/oai||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com2238-33602238-3360opendoar:2019-04-01T12:52:45Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC)false
dc.title.none.fl_str_mv Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe
Leishmaniasis Visceral: Características clínico-epidemiológicas de casos y muertes en el estado de Sergipe
Leishmaniose Visceral: Características clínico-epidemiológicas de casos e óbitos no estado de Sergipe
title Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe
spellingShingle Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe
Santos, Matheus de Albuquerque
title_short Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe
title_full Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe
title_fullStr Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe
title_full_unstemmed Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe
title_sort Visceral Leishmaniasis: Clinical-epidemiological characteristics of cases and deaths in the state of Sergipe
author Santos, Matheus de Albuquerque
author_facet Santos, Matheus de Albuquerque
Rodrigues, Samuel Lucas Calmon
Nascimento, Aécio Lindenberg Figueiredo
Rodrigues, Jamylle Souza
Góes, Marco Aurélio de Oliveira
author_role author
author2 Rodrigues, Samuel Lucas Calmon
Nascimento, Aécio Lindenberg Figueiredo
Rodrigues, Jamylle Souza
Góes, Marco Aurélio de Oliveira
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Santos, Matheus de Albuquerque
Rodrigues, Samuel Lucas Calmon
Nascimento, Aécio Lindenberg Figueiredo
Rodrigues, Jamylle Souza
Góes, Marco Aurélio de Oliveira
description Background and Objectives: Visceral Leishmaniasis (VL) is an endemic antropozoonosis in tropical areas that has been showing expansion and global increase in lethality. This work aims to characterize clinical and epidemiological aspects of VL, identifying factors associated with death. Methods: This is an observational epidemiological study, using data from the state database of LV cases residing in the state of Sergipe, notified between 2007 and 2016 at the SINAN (Information System for Notifiable Diseases). Results: 577 confirmed cases of VL were reported, with concentration in the urban area (76.1%), with a general lethality of 12.3%. There was a predominance of males (69.5%), with higher lethality. The highest concentration of cases occurred in the first decade of life (38.5%). The lethality increased every decade from the age of 40, reaching 39.3% in people 60 years of age or older. In both quinquennia (2007 - 2011 and 2012 - 2016), it was observed that the mean incidence rate (MIC) in children under 10 years is similar between both sexes and from that point on, it is always higher in males. The manifestations related to higher lethality were: hemorrhages (30.3%), jaundice (28.1%), infection (26.4%), edema (25.1%) and HIV coinfection (26,9%). Conclusion: Despite being an endemic transmission area of LV, there have been changes in the epidemiological pattern with an increase in the incidence in the population over 40 years, which may reflect the increase in lethality. The identification of this new scenario and the recognition of signs of gravity are very important for its early diagnosis and timely treatment.
publishDate 2018
dc.date.none.fl_str_mv 2018-10-08
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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dc.identifier.uri.fl_str_mv https://online.unisc.br/seer/index.php/epidemiologia/article/view/11591
10.17058/reci.v8i4.11591
url https://online.unisc.br/seer/index.php/epidemiologia/article/view/11591
identifier_str_mv 10.17058/reci.v8i4.11591
dc.language.iso.fl_str_mv por
eng
language por
eng
dc.relation.none.fl_str_mv https://online.unisc.br/seer/index.php/epidemiologia/article/view/11591/7623
https://online.unisc.br/seer/index.php/epidemiologia/article/view/11591/7815
dc.rights.driver.fl_str_mv Copyright (c) 2018 Marco Aurélio de Oliveira Góes
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2018 Marco Aurélio de Oliveira Góes
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Unisc
publisher.none.fl_str_mv Unisc
dc.source.none.fl_str_mv Revista de Epidemiologia e Controle de Infecção; Vol. 8 No. 4 (2018); 428-434
Revista de Epidemiologia e Controle de Infecção; v. 8 n. 4 (2018); 428-434
2238-3360
reponame:Revista de Epidemiologia e Controle de Infecção
instname:Universidade de Santa Cruz do Sul (UNISC)
instacron:UNISC
instname_str Universidade de Santa Cruz do Sul (UNISC)
instacron_str UNISC
institution UNISC
reponame_str Revista de Epidemiologia e Controle de Infecção
collection Revista de Epidemiologia e Controle de Infecção
repository.name.fl_str_mv Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC)
repository.mail.fl_str_mv ||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com
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