Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista de Epidemiologia e Controle de Infecção |
Texto Completo: | https://online.unisc.br/seer/index.php/epidemiologia/article/view/6574 |
Resumo: | Background and Objectives: Fluoroquinolones represent a class of amtimicrobials which isfrequently prescribed for the treatment of urinary tract infections (UTIs) of both hospital and community origin. This study aims, to determine the frequency and the factors associated with resistance to ciprofloxacin and levofloxacin in gram-negative bacilli isolated from patients with UTIs treated in a hospital in southern Brazil. Methods: It was performed a transversal and analytical study based on cases of urinary tract infection caused by gram-negative bacteria (GNB) from patients at the Hospital Universitário Dr. Miguel Riet Correa Jr. in Rio Grande/RS from August 2012 to July 2013. Independent variables such as the age and sex of patients, source of infection of the UTI and the characteristics of the bacterial isolates were analyzed. Results: Of the 562 GNB isolated andanalyzed, the total frequencies of ciprofloxacin and levofloxacin resistance were, respectively, 25.5% and 23.3%, 62.6% community origin and 59% in hospital origin. The risk factors associated with ciprofloxacin and levofloxacin resistance were male patients, infections acquired in the hospital, longer hospitalization times, and the presence of extended spectrum β-lactamases (ESBLs) in the clinical isolates. Conclusions:The results showed strong association between GNB resistancewith the time spent in the hospital and the presence of ESBLs. To control antibiotic resistance andthe reduction the costs in public health, it is necessary that thehospitals have a strong policy ofcontinues vigilanceof the use of and of the resistance of antibiotics. KEYWORDS: Bacteria. Fluoroquinolones. Cross Infection. |
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Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infectionsFatores associados com a resistência a Ciprofloxacina e Levofloxacina em Bacilos Gram-Negativos isolados de infecções do trato urinárioBackground and Objectives: Fluoroquinolones represent a class of amtimicrobials which isfrequently prescribed for the treatment of urinary tract infections (UTIs) of both hospital and community origin. This study aims, to determine the frequency and the factors associated with resistance to ciprofloxacin and levofloxacin in gram-negative bacilli isolated from patients with UTIs treated in a hospital in southern Brazil. Methods: It was performed a transversal and analytical study based on cases of urinary tract infection caused by gram-negative bacteria (GNB) from patients at the Hospital Universitário Dr. Miguel Riet Correa Jr. in Rio Grande/RS from August 2012 to July 2013. Independent variables such as the age and sex of patients, source of infection of the UTI and the characteristics of the bacterial isolates were analyzed. Results: Of the 562 GNB isolated andanalyzed, the total frequencies of ciprofloxacin and levofloxacin resistance were, respectively, 25.5% and 23.3%, 62.6% community origin and 59% in hospital origin. The risk factors associated with ciprofloxacin and levofloxacin resistance were male patients, infections acquired in the hospital, longer hospitalization times, and the presence of extended spectrum β-lactamases (ESBLs) in the clinical isolates. Conclusions:The results showed strong association between GNB resistancewith the time spent in the hospital and the presence of ESBLs. To control antibiotic resistance andthe reduction the costs in public health, it is necessary that thehospitals have a strong policy ofcontinues vigilanceof the use of and of the resistance of antibiotics. KEYWORDS: Bacteria. Fluoroquinolones. Cross Infection.Justificativa e objetivos: As fluoroquinolonas representam uma classe de antimicrobianos que é frequentemente prescrita no tratamento de infecções do trato urinário (ITU), tanto de origem hospitalar como originárias da comunidade. Este estudo tem como objetivo,determinar a frequência de resistência à ciprofloxacina e levofloxacina, além de seus fatores associados em bacilos Gram negativos (BGN) isolados de pacientes com ITU em um hospital no Sul do Brasil. Métodos: foi realizado um estudo transversal e analítico, baseado em casos de infecções do trato urinário causadas por bactérias gram-negativas provenientes de pacientes atendidos no Hospital Universitário Dr. Miguel Riet Correa Jr. em Rio Grande/RS, de agosto de 2012 a julho 2013. Foram analisadas variáveis independentes como idade, sexo, origem da infecção e características dos isolados clínicos bacterianos. Resultados:Dos 562 BGN isolados e analisados, foi encontrado uma frequência de resistência à ciprofloxacina e à levofloxacina de 25,5 e 23,3%, respectivamente, 62,6% de origem comunitária e 59% de origem hospitalar. Os fatores de risco associados à resistência a ciprofloxacina e levofloxacina, foram pacientes do gênero masculino, infecções adquiridas no ambiente hospitalar, commaior tempo de internação, e apresença de β-lactamases de espectro estendido (ESBL) nos isolados clínicos. Conclusões:Os resultados mostraram uma forte associação da resistência bacteriana de BGN com a permanência no ambiente hospitalar e a presença de ESBL. A fim de controlar a resistência antimicrobiana e a redução nos custos em saúde pública torna-se necessário que os hospitais tenham uma forte política de vigilância contínua do uso e da resistência de antibióticos.Unisc2016-01-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/657410.17058/reci.v6i1.6574Revista de Epidemiologia e Controle de Infecção; Vol. 6 No. 1 (2016); 18-23Revista de Epidemiologia e Controle de Infecção; v. 6 n. 1 (2016); 18-232238-3360reponame:Revista de Epidemiologia e Controle de Infecçãoinstname:Universidade de Santa Cruz do Sul (UNISC)instacron:UNISCporhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/6574/5054Copyright (c) 2016 Revista de Epidemiologia e Controle de Infecçãoinfo:eu-repo/semantics/openAccessVolcão, Lisiane MartinsLacava, Juliano PereiraRamis, Ivy BastosRamos, Daniela FernandesDamati, Gustavo SoutoGonçalves, Carla VitolaSilva, Pedro Eduardo Almeida daGroll, Andrea von2019-01-21T12:54:22Zoai:ojs.online.unisc.br:article/6574Revistahttps://online.unisc.br/seer/index.php/epidemiologia/indexONGhttp://online.unisc.br/seer/index.php/epidemiologia/oai||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com2238-33602238-3360opendoar:2019-01-21T12:54:22Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC)false |
dc.title.none.fl_str_mv |
Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections Fatores associados com a resistência a Ciprofloxacina e Levofloxacina em Bacilos Gram-Negativos isolados de infecções do trato urinário |
title |
Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections |
spellingShingle |
Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections Volcão, Lisiane Martins |
title_short |
Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections |
title_full |
Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections |
title_fullStr |
Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections |
title_full_unstemmed |
Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections |
title_sort |
Factors associated with ciprofloxacin and Levofloxacin resistance in Gram-Negative Bacilli isolated from urinary tract infections |
author |
Volcão, Lisiane Martins |
author_facet |
Volcão, Lisiane Martins Lacava, Juliano Pereira Ramis, Ivy Bastos Ramos, Daniela Fernandes Damati, Gustavo Souto Gonçalves, Carla Vitola Silva, Pedro Eduardo Almeida da Groll, Andrea von |
author_role |
author |
author2 |
Lacava, Juliano Pereira Ramis, Ivy Bastos Ramos, Daniela Fernandes Damati, Gustavo Souto Gonçalves, Carla Vitola Silva, Pedro Eduardo Almeida da Groll, Andrea von |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Volcão, Lisiane Martins Lacava, Juliano Pereira Ramis, Ivy Bastos Ramos, Daniela Fernandes Damati, Gustavo Souto Gonçalves, Carla Vitola Silva, Pedro Eduardo Almeida da Groll, Andrea von |
description |
Background and Objectives: Fluoroquinolones represent a class of amtimicrobials which isfrequently prescribed for the treatment of urinary tract infections (UTIs) of both hospital and community origin. This study aims, to determine the frequency and the factors associated with resistance to ciprofloxacin and levofloxacin in gram-negative bacilli isolated from patients with UTIs treated in a hospital in southern Brazil. Methods: It was performed a transversal and analytical study based on cases of urinary tract infection caused by gram-negative bacteria (GNB) from patients at the Hospital Universitário Dr. Miguel Riet Correa Jr. in Rio Grande/RS from August 2012 to July 2013. Independent variables such as the age and sex of patients, source of infection of the UTI and the characteristics of the bacterial isolates were analyzed. Results: Of the 562 GNB isolated andanalyzed, the total frequencies of ciprofloxacin and levofloxacin resistance were, respectively, 25.5% and 23.3%, 62.6% community origin and 59% in hospital origin. The risk factors associated with ciprofloxacin and levofloxacin resistance were male patients, infections acquired in the hospital, longer hospitalization times, and the presence of extended spectrum β-lactamases (ESBLs) in the clinical isolates. Conclusions:The results showed strong association between GNB resistancewith the time spent in the hospital and the presence of ESBLs. To control antibiotic resistance andthe reduction the costs in public health, it is necessary that thehospitals have a strong policy ofcontinues vigilanceof the use of and of the resistance of antibiotics. KEYWORDS: Bacteria. Fluoroquinolones. Cross Infection. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-01-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/6574 10.17058/reci.v6i1.6574 |
url |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/6574 |
identifier_str_mv |
10.17058/reci.v6i1.6574 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://online.unisc.br/seer/index.php/epidemiologia/article/view/6574/5054 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2016 Revista de Epidemiologia e Controle de Infecção info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2016 Revista de Epidemiologia e Controle de Infecção |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Unisc |
publisher.none.fl_str_mv |
Unisc |
dc.source.none.fl_str_mv |
Revista de Epidemiologia e Controle de Infecção; Vol. 6 No. 1 (2016); 18-23 Revista de Epidemiologia e Controle de Infecção; v. 6 n. 1 (2016); 18-23 2238-3360 reponame:Revista de Epidemiologia e Controle de Infecção instname:Universidade de Santa Cruz do Sul (UNISC) instacron:UNISC |
instname_str |
Universidade de Santa Cruz do Sul (UNISC) |
instacron_str |
UNISC |
institution |
UNISC |
reponame_str |
Revista de Epidemiologia e Controle de Infecção |
collection |
Revista de Epidemiologia e Controle de Infecção |
repository.name.fl_str_mv |
Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC) |
repository.mail.fl_str_mv |
||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com |
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1800218810163134464 |