Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil

Detalhes bibliográficos
Autor(a) principal: Tessmann, Beatriz Adriana
Data de Publicação: 2017
Outros Autores: Caballero, Paula Alencastro, Martins, Andreza Francisco, Perez, Vinícius Pieta
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Epidemiologia e Controle de Infecção
Texto Completo: https://online.unisc.br/seer/index.php/epidemiologia/article/view/9345
Resumo: Background and Objectives: Several infections by multidrug-resistant Klebsiella spp. have been report worldwide, because of the capacity of these bacteria in acquire many resistance mechanisms and rapidly spread through clinical units. The aim of this study was evaluate the antimicrobial susceptibility profile of Klebsiella spp. in a hospital of a country town of Rio Grande do Sul, Brazil. Methods: This study investigated the resistance profile of Klebsiella spp. strains isolated between 2014 and 2015, in a regional hospital of a small town. The patient’s charts and microbiological assays were review, including age, sex, date, anatomical site of isolation, origin, and antimicrobial susceptibility test. Results: Forty-two strains were isolated during 2014 and 2015. The positive cultures were from urine (57%), secretions (38%), and blood (5%). Was observed antibiotic resistance in 81% of the strains, and 62% showed multidrugresistance. The resistance profile for β-lactams, mainly cefalosporin and carbapenem, and for aminoglycosides and tetracycline increased in the study period. Conclusion: In this study we showed an increase in antibiotic resistance in a hospital at a small town, highlighting the emergence of carbapenem resistant Klebsiella spp. during 2015. The spread of multidrug-resistant bacteria in this hospital enhance the importance of epidemiological surveillance and establishment of infection control procedures.
id UNISC-4_e985846775e638cbe24a4237af310a8a
oai_identifier_str oai:ojs.online.unisc.br:article/9345
network_acronym_str UNISC-4
network_name_str Revista de Epidemiologia e Controle de Infecção
repository_id_str
spelling Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, BrazilLa elevación de la resistencia antimicrobiana en Klebsiella spp. en el municipio del Estado de Rio Grande do Sul, BrasilEmergência de resistência antimicrobiana em Klebsiella spp. em município do interior do Estado do Rio Grande do Sul, BrasilBackground and Objectives: Several infections by multidrug-resistant Klebsiella spp. have been report worldwide, because of the capacity of these bacteria in acquire many resistance mechanisms and rapidly spread through clinical units. The aim of this study was evaluate the antimicrobial susceptibility profile of Klebsiella spp. in a hospital of a country town of Rio Grande do Sul, Brazil. Methods: This study investigated the resistance profile of Klebsiella spp. strains isolated between 2014 and 2015, in a regional hospital of a small town. The patient’s charts and microbiological assays were review, including age, sex, date, anatomical site of isolation, origin, and antimicrobial susceptibility test. Results: Forty-two strains were isolated during 2014 and 2015. The positive cultures were from urine (57%), secretions (38%), and blood (5%). Was observed antibiotic resistance in 81% of the strains, and 62% showed multidrugresistance. The resistance profile for β-lactams, mainly cefalosporin and carbapenem, and for aminoglycosides and tetracycline increased in the study period. Conclusion: In this study we showed an increase in antibiotic resistance in a hospital at a small town, highlighting the emergence of carbapenem resistant Klebsiella spp. during 2015. The spread of multidrug-resistant bacteria in this hospital enhance the importance of epidemiological surveillance and establishment of infection control procedures.Justificación y Objetivos: Las infecciones por Klebsiella spp. multirresistentes se han propagado a todas las regiones del mundo debido a su capacidad en adquirir mecanismos de resistencia y la rápida diseminación. El objetivo de essa investigación fue determinar el patrón de sensibilidad antimicrobiana de Klebsiella spp. en un hospital del estado de Rio Grande do Sul. Métodos: Se incluyeron todos los casos con cultivos positivos para Klebsiella spp. dentre los años 2014 y 2015. Los datos de los cultivos microbiológicos y registros médicos, edad, sexo, fecha, sitio anatómico del aislamiento, origen y los resultados de las pruebas de sensibilidad a los antimicrobianos fueron obtenidas del pacientes. Resultados: Durante el período se incluyeron 42 casos, 57% de las vías urinarias, 38% de las secreciones corporales, y 5% del torrente sanguíneo. Se observó resistencia en 81% de los casos y resistencia a múltiples fármacos en 62%. Durante el período se observó una reducción en la sensibilidad a los antibióticos β-lactámicos, en particular de cefalosporinas y carbapenémicos, aminoglicósidos y tetraciclinas. Conclusiones: Los resultados obtenidos muestran un aumento significativo de la resistencia a múltiples fármacos en la localidad, sobre todo la aparición de resistencia a los carbapenémicos ocurrido en 2015. La amenaza de establecimiento local de essas cepas alerta a la necesidad de medidas de control de las infecciones.Justificativa e Objetivos: Infecções por Klebsiella spp. multirresistentes têm sido relatadas globalmente em decorrência da capacidade de aquisição de diversos mecanismos de resistência e rápida propagação destes microrganismos. Assim, o objetivo deste estudo foi descrever a variação do perfil de suscetibilidade aos antimicrobianos de Klebsiella spp. em um hospital no interior do Estado do Rio Grande do Sul. Métodos: Foram incluídos todos os casos de pacientes com culturas de urina, hemoculturas ou culturas de secreções positiva para Klebsiella spp. entre os anos de 2014 e 2015. Os dados das culturas microbiológicas e dos prontuários médicos foram revisados sendo coletadas as seguintes variáveis, idade, sexo, data, sítio anatômico de isolamento, origem, e resultados do teste de suscetibilidade aos antimicrobianos. Resultados: Durante o período ocorreram 42 casos, sendo 57% de culturas do trato urinário, seguido de secreções 38% e infecções de corrente sanguínea 5%. Foram observadas resistências em 81% dos isolados, e multirresistência em 62%. No período houve significativa redução da suscetibilidade para a classe dos β-lactâmicos, principalmente cefalosporinas e carbapenêmicos, aminoglicosídeos e tetraciclinas. Conclusão: Os dados obtidos demonstram um significativo aumento da multirresistência aos antimicrobianos na localidade, com destaque para a emergência de resistência aos carbapenêmicos ocorrida no ano de 2015. A ameaça do estabelecimento local destes isolados alerta para a necessidade do contínuo monitoramento e implementação de medidas de controle de infecção.Unisc2017-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/934510.17058/reci.v7i4.9345Revista de Epidemiologia e Controle de Infecção; Vol. 7 No. 4 (2017); 215-220Revista de Epidemiologia e Controle de Infecção; v. 7 n. 4 (2017); 215-2202238-3360reponame:Revista de Epidemiologia e Controle de Infecçãoinstname:Universidade de Santa Cruz do Sul (UNISC)instacron:UNISCporhttps://online.unisc.br/seer/index.php/epidemiologia/article/view/9345/6247Copyright (c) 2017 Revista de Epidemiologia e Controle de Infecçãoinfo:eu-repo/semantics/openAccessTessmann, Beatriz AdrianaCaballero, Paula AlencastroMartins, Andreza FranciscoPerez, Vinícius Pieta2019-01-21T12:52:25Zoai:ojs.online.unisc.br:article/9345Revistahttps://online.unisc.br/seer/index.php/epidemiologia/indexONGhttp://online.unisc.br/seer/index.php/epidemiologia/oai||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com2238-33602238-3360opendoar:2019-01-21T12:52:25Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC)false
dc.title.none.fl_str_mv Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil
La elevación de la resistencia antimicrobiana en Klebsiella spp. en el municipio del Estado de Rio Grande do Sul, Brasil
Emergência de resistência antimicrobiana em Klebsiella spp. em município do interior do Estado do Rio Grande do Sul, Brasil
title Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil
spellingShingle Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil
Tessmann, Beatriz Adriana
title_short Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil
title_full Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil
title_fullStr Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil
title_full_unstemmed Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil
title_sort Rise of antimicrobial resistance in Klebsiella spp. in a country town of Rio Grande do Sul, Brazil
author Tessmann, Beatriz Adriana
author_facet Tessmann, Beatriz Adriana
Caballero, Paula Alencastro
Martins, Andreza Francisco
Perez, Vinícius Pieta
author_role author
author2 Caballero, Paula Alencastro
Martins, Andreza Francisco
Perez, Vinícius Pieta
author2_role author
author
author
dc.contributor.author.fl_str_mv Tessmann, Beatriz Adriana
Caballero, Paula Alencastro
Martins, Andreza Francisco
Perez, Vinícius Pieta
description Background and Objectives: Several infections by multidrug-resistant Klebsiella spp. have been report worldwide, because of the capacity of these bacteria in acquire many resistance mechanisms and rapidly spread through clinical units. The aim of this study was evaluate the antimicrobial susceptibility profile of Klebsiella spp. in a hospital of a country town of Rio Grande do Sul, Brazil. Methods: This study investigated the resistance profile of Klebsiella spp. strains isolated between 2014 and 2015, in a regional hospital of a small town. The patient’s charts and microbiological assays were review, including age, sex, date, anatomical site of isolation, origin, and antimicrobial susceptibility test. Results: Forty-two strains were isolated during 2014 and 2015. The positive cultures were from urine (57%), secretions (38%), and blood (5%). Was observed antibiotic resistance in 81% of the strains, and 62% showed multidrugresistance. The resistance profile for β-lactams, mainly cefalosporin and carbapenem, and for aminoglycosides and tetracycline increased in the study period. Conclusion: In this study we showed an increase in antibiotic resistance in a hospital at a small town, highlighting the emergence of carbapenem resistant Klebsiella spp. during 2015. The spread of multidrug-resistant bacteria in this hospital enhance the importance of epidemiological surveillance and establishment of infection control procedures.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://online.unisc.br/seer/index.php/epidemiologia/article/view/9345
10.17058/reci.v7i4.9345
url https://online.unisc.br/seer/index.php/epidemiologia/article/view/9345
identifier_str_mv 10.17058/reci.v7i4.9345
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://online.unisc.br/seer/index.php/epidemiologia/article/view/9345/6247
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista de Epidemiologia e Controle de Infecção
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista de Epidemiologia e Controle de Infecção
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Unisc
publisher.none.fl_str_mv Unisc
dc.source.none.fl_str_mv Revista de Epidemiologia e Controle de Infecção; Vol. 7 No. 4 (2017); 215-220
Revista de Epidemiologia e Controle de Infecção; v. 7 n. 4 (2017); 215-220
2238-3360
reponame:Revista de Epidemiologia e Controle de Infecção
instname:Universidade de Santa Cruz do Sul (UNISC)
instacron:UNISC
instname_str Universidade de Santa Cruz do Sul (UNISC)
instacron_str UNISC
institution UNISC
reponame_str Revista de Epidemiologia e Controle de Infecção
collection Revista de Epidemiologia e Controle de Infecção
repository.name.fl_str_mv Revista de Epidemiologia e Controle de Infecção - Universidade de Santa Cruz do Sul (UNISC)
repository.mail.fl_str_mv ||liapossuelo@unisc.br|| julia.kern@hotmail.com||reci.unisc@gmail.com
_version_ 1800218810723074048

Registros relacionados