Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2

Detalhes bibliográficos
Autor(a) principal: Gomes Dantas, Maria Karoline
Data de Publicação: 2023
Outros Autores: Silva Ramos, Letícia Francine, Fernandes Costa, Moan Jefter, Sette-de-Souza, Pedro Henrique
Tipo de documento: Artigo
Idioma: por
Título da fonte: Interfaces Científicas. Saúde e Ambiente (Online)
Texto Completo: https://periodicos.set.edu.br/saude/article/view/11563
Resumo: The SARS-CoV2 virus is highly transmissible and dental surgeons are a risk group. Health authorities have proposed the use of mouthwash before procedures in order to prevent contamination. However, these are not able to reduce the salivary viral load. Thus, the aim of this study was to evaluate, in silico, the potential of compounds from Schinopsis brasiliensis plant species against SARS-CoV-2. The results showed that the compounds Schinopsona B, alpha-amyrin and chlorogenic acid showed binding affinity with viral proteins, besides low toxicity, being promising for further research and development of antiseptic oral solution against COVID-19.
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spelling Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2Bioprospección de compuestos de Schinopsis brasiliensis para el desarrollo de una solución oral contra el SARS-CoV-2BIOPROSPECÇÃO DE COMPOSTOS DA SCHINOPSIS BRASILIENSIS PARA O DESENVOLVIMENTO DE SOLUÇÃO ORAL CONTRA O SARS-COV-2The SARS-CoV2 virus is highly transmissible and dental surgeons are a risk group. Health authorities have proposed the use of mouthwash before procedures in order to prevent contamination. However, these are not able to reduce the salivary viral load. Thus, the aim of this study was to evaluate, in silico, the potential of compounds from Schinopsis brasiliensis plant species against SARS-CoV-2. The results showed that the compounds Schinopsona B, alpha-amyrin and chlorogenic acid showed binding affinity with viral proteins, besides low toxicity, being promising for further research and development of antiseptic oral solution against COVID-19.El virus SARS-CoV2 es altamente transmisible y los cirujanos dentales constituyen un grupo de riesgo. Las autoridades sanitarias han propuesto el uso de enjuagues bucales antes de los procedimientos para evitar la contaminación. Sin embargo, éstos no son capaces de reducir la carga viral salival. Así pues, el objetivo de este estudio era evaluar, in silico, el potencial de los compuestos de la especie vegetal Schinopsis brasiliensis contra el SARS-CoV-2. Los resultados mostraron que los compuestos Schinopsona B, alfa-amirina y ácido clorogénico mostraron afinidad de unión con proteínas virales, además de baja toxicidad, siendo prometedores para futuras investigaciones y posterior desarrollo de solución oral antiséptica contra COVID-19.O vírus SARS-CoV2 possui alta transmissibilidade, onde tem-se os cirurgiões-dentistas como grupo de risco. Autoridades sanitárias propuseram uso de colutórios anterior aos procedimentos a fim de prevenir a contaminação. Porém, estes não são capazes de diminuir a carga salivar viral. Assim, o objetivo deste estudo foi avaliar, in silico, o potencial de compostos da espécie vegetal Schinopsis brasiliensis frente ao SARS-CoV-2. Os resultados mostraram que, os compostos Schinopsona B, Alfa-amirina e Ácido clorogênico apresentaram afinidade de ligação com as proteínas virais, além de baixa toxicidade, sendo promissores para novas pesquisas e posterior desenvolvimento de solução oral antisséptica contra à COVID-19.Editora Universitária Tiradentes2023-12-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.set.edu.br/saude/article/view/1156310.17564/2316-3798.2023v9n2p469-482Interfaces Científicas - Saúde e Ambiente; v. 9 n. 2 (2023): Fluxo Contínuo; 469-4822316-37982316-331310.17564/2316-3798.2023v9n2reponame:Interfaces Científicas. Saúde e Ambiente (Online)instname:Universidade Tiradentes (UNIT)instacron:UNITporhttps://periodicos.set.edu.br/saude/article/view/11563/5488Copyright (c) 2023 Interfaces Científicas - Saúde e Ambientehttps://creativecommons.org/licenses/by-nc/4.0info:eu-repo/semantics/openAccessGomes Dantas, Maria Karoline Silva Ramos, Letícia FrancineFernandes Costa, Moan JefterSette-de-Souza, Pedro Henrique2023-12-05T13:10:24Zoai:ojs.emnuvens.com.br:article/11563Revistahttps://periodicos.set.edu.br/saudePRIhttps://periodicos.set.edu.br/index.php/saude/oai||crismporto@gmail.com||interfaces_saude_editor@yahoo.com.br2316-37982316-3313opendoar:2023-12-05T13:10:24Interfaces Científicas. Saúde e Ambiente (Online) - Universidade Tiradentes (UNIT)false
dc.title.none.fl_str_mv Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2
Bioprospección de compuestos de Schinopsis brasiliensis para el desarrollo de una solución oral contra el SARS-CoV-2
BIOPROSPECÇÃO DE COMPOSTOS DA SCHINOPSIS BRASILIENSIS PARA O DESENVOLVIMENTO DE SOLUÇÃO ORAL CONTRA O SARS-COV-2
title Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2
spellingShingle Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2
Gomes Dantas, Maria Karoline
title_short Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2
title_full Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2
title_fullStr Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2
title_full_unstemmed Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2
title_sort Bioprospecting of compounds from Schinopsis brasiliensis for the development of an oral solution against SARS-CoV-2
author Gomes Dantas, Maria Karoline
author_facet Gomes Dantas, Maria Karoline
Silva Ramos, Letícia Francine
Fernandes Costa, Moan Jefter
Sette-de-Souza, Pedro Henrique
author_role author
author2 Silva Ramos, Letícia Francine
Fernandes Costa, Moan Jefter
Sette-de-Souza, Pedro Henrique
author2_role author
author
author
dc.contributor.author.fl_str_mv Gomes Dantas, Maria Karoline
Silva Ramos, Letícia Francine
Fernandes Costa, Moan Jefter
Sette-de-Souza, Pedro Henrique
description The SARS-CoV2 virus is highly transmissible and dental surgeons are a risk group. Health authorities have proposed the use of mouthwash before procedures in order to prevent contamination. However, these are not able to reduce the salivary viral load. Thus, the aim of this study was to evaluate, in silico, the potential of compounds from Schinopsis brasiliensis plant species against SARS-CoV-2. The results showed that the compounds Schinopsona B, alpha-amyrin and chlorogenic acid showed binding affinity with viral proteins, besides low toxicity, being promising for further research and development of antiseptic oral solution against COVID-19.
publishDate 2023
dc.date.none.fl_str_mv 2023-12-04
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.set.edu.br/saude/article/view/11563
10.17564/2316-3798.2023v9n2p469-482
url https://periodicos.set.edu.br/saude/article/view/11563
identifier_str_mv 10.17564/2316-3798.2023v9n2p469-482
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.set.edu.br/saude/article/view/11563/5488
dc.rights.driver.fl_str_mv Copyright (c) 2023 Interfaces Científicas - Saúde e Ambiente
https://creativecommons.org/licenses/by-nc/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Interfaces Científicas - Saúde e Ambiente
https://creativecommons.org/licenses/by-nc/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editora Universitária Tiradentes
publisher.none.fl_str_mv Editora Universitária Tiradentes
dc.source.none.fl_str_mv Interfaces Científicas - Saúde e Ambiente; v. 9 n. 2 (2023): Fluxo Contínuo; 469-482
2316-3798
2316-3313
10.17564/2316-3798.2023v9n2
reponame:Interfaces Científicas. Saúde e Ambiente (Online)
instname:Universidade Tiradentes (UNIT)
instacron:UNIT
instname_str Universidade Tiradentes (UNIT)
instacron_str UNIT
institution UNIT
reponame_str Interfaces Científicas. Saúde e Ambiente (Online)
collection Interfaces Científicas. Saúde e Ambiente (Online)
repository.name.fl_str_mv Interfaces Científicas. Saúde e Ambiente (Online) - Universidade Tiradentes (UNIT)
repository.mail.fl_str_mv ||crismporto@gmail.com||interfaces_saude_editor@yahoo.com.br
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