EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS

Detalhes bibliográficos
Autor(a) principal: Grinet, Marco Antonio Vieira
Data de Publicação: 2017
Outros Autores: Pedroso, Thiago Moreira, Marciano, Fernanda Roberta
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista UniVap (online)
Texto Completo: https://revista.univap.br/index.php/revistaunivap/article/view/1680
Resumo: An in vitro encapsulation platform utilizing hydrogels and bone matrix (BM) scaffolds to investigate the effects of microenvironmental parameters on encapsulated goat mesenchymal stem cells (gMSC) was presented. The base encapsulation matrix was composed of a biocompatible hydrogel formed through a photoinitiated polymerization process. Different polymer concentrations were used to compare the effects of hydrogel crosslinking density on physical properties, as well as on cell viability. The potential of BM to support the growth and differentiation of gMSC was also analyzed. Both methods were compared in order to analyze viability. Structures that better allow flow of oxygen showed more promising results, whereas BM structures require a better evaluation method for concrete results.
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spelling EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDSCell CulturegMSCBone MatrixHydrogelCell EncapsAn in vitro encapsulation platform utilizing hydrogels and bone matrix (BM) scaffolds to investigate the effects of microenvironmental parameters on encapsulated goat mesenchymal stem cells (gMSC) was presented. The base encapsulation matrix was composed of a biocompatible hydrogel formed through a photoinitiated polymerization process. Different polymer concentrations were used to compare the effects of hydrogel crosslinking density on physical properties, as well as on cell viability. The potential of BM to support the growth and differentiation of gMSC was also analyzed. Both methods were compared in order to analyze viability. Structures that better allow flow of oxygen showed more promising results, whereas BM structures require a better evaluation method for concrete results.IBICT2017-01-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://revista.univap.br/index.php/revistaunivap/article/view/168010.18066/revistaunivap.v22i40.1680Revista Univap; Vol. 22 No. 40 (2016): Revista Univap online Edição Especial XX Encontro de Iniciação Científica, XVI Encontro de Pós-Graduação, X INIC Jr e VI INID da Universidade do Vale do Paraíba / ISSN 2237-1753; 253Revista Univap; v. 22 n. 40 (2016): Revista Univap online Edição Especial XX Encontro de Iniciação Científica, XVI Encontro de Pós-Graduação, X INIC Jr e VI INID da Universidade do Vale do Paraíba / ISSN 2237-1753; 2532237-17531517-327510.18066/revistaunivap.v22i40reponame:Revista UniVap (online)instname:Universidade do Vale do Paraíba (Univap)instacron:UNIVAPenghttps://revista.univap.br/index.php/revistaunivap/article/view/1680/616Copyright (c) 2017 Revista Univapinfo:eu-repo/semantics/openAccessGrinet, Marco Antonio VieiraPedroso, Thiago MoreiraMarciano, Fernanda Roberta2020-01-08T15:48:39Zoai:ojs.biblioteca.univap.br:article/1680Revistahttps://revista.univap.br/index.php/revistaunivapPRIhttps://revista.univap.br/index.php/revistaunivap/oairevista@univap.br2237-17532237-1753opendoar:2020-01-08T15:48:39Revista UniVap (online) - Universidade do Vale do Paraíba (Univap)false
dc.title.none.fl_str_mv EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
title EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
spellingShingle EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
Grinet, Marco Antonio Vieira
Cell Culture
gMSC
Bone Matrix
Hydrogel
Cell Encaps
title_short EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
title_full EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
title_fullStr EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
title_full_unstemmed EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
title_sort EXTRACELLULAR MIMETICS: A COMPARATIVE EVALUATION OF CELL ENCAPSULATION UTILIZING HYDROGELS AND SCAFFOLDS
author Grinet, Marco Antonio Vieira
author_facet Grinet, Marco Antonio Vieira
Pedroso, Thiago Moreira
Marciano, Fernanda Roberta
author_role author
author2 Pedroso, Thiago Moreira
Marciano, Fernanda Roberta
author2_role author
author
dc.contributor.author.fl_str_mv Grinet, Marco Antonio Vieira
Pedroso, Thiago Moreira
Marciano, Fernanda Roberta
dc.subject.por.fl_str_mv Cell Culture
gMSC
Bone Matrix
Hydrogel
Cell Encaps
topic Cell Culture
gMSC
Bone Matrix
Hydrogel
Cell Encaps
description An in vitro encapsulation platform utilizing hydrogels and bone matrix (BM) scaffolds to investigate the effects of microenvironmental parameters on encapsulated goat mesenchymal stem cells (gMSC) was presented. The base encapsulation matrix was composed of a biocompatible hydrogel formed through a photoinitiated polymerization process. Different polymer concentrations were used to compare the effects of hydrogel crosslinking density on physical properties, as well as on cell viability. The potential of BM to support the growth and differentiation of gMSC was also analyzed. Both methods were compared in order to analyze viability. Structures that better allow flow of oxygen showed more promising results, whereas BM structures require a better evaluation method for concrete results.
publishDate 2017
dc.date.none.fl_str_mv 2017-01-09
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revista.univap.br/index.php/revistaunivap/article/view/1680
10.18066/revistaunivap.v22i40.1680
url https://revista.univap.br/index.php/revistaunivap/article/view/1680
identifier_str_mv 10.18066/revistaunivap.v22i40.1680
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revista.univap.br/index.php/revistaunivap/article/view/1680/616
dc.rights.driver.fl_str_mv Copyright (c) 2017 Revista Univap
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2017 Revista Univap
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv IBICT
publisher.none.fl_str_mv IBICT
dc.source.none.fl_str_mv Revista Univap; Vol. 22 No. 40 (2016): Revista Univap online Edição Especial XX Encontro de Iniciação Científica, XVI Encontro de Pós-Graduação, X INIC Jr e VI INID da Universidade do Vale do Paraíba / ISSN 2237-1753; 253
Revista Univap; v. 22 n. 40 (2016): Revista Univap online Edição Especial XX Encontro de Iniciação Científica, XVI Encontro de Pós-Graduação, X INIC Jr e VI INID da Universidade do Vale do Paraíba / ISSN 2237-1753; 253
2237-1753
1517-3275
10.18066/revistaunivap.v22i40
reponame:Revista UniVap (online)
instname:Universidade do Vale do Paraíba (Univap)
instacron:UNIVAP
instname_str Universidade do Vale do Paraíba (Univap)
instacron_str UNIVAP
institution UNIVAP
reponame_str Revista UniVap (online)
collection Revista UniVap (online)
repository.name.fl_str_mv Revista UniVap (online) - Universidade do Vale do Paraíba (Univap)
repository.mail.fl_str_mv revista@univap.br
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