ANTIBACTERIAL AND MODULATORY ACTIVITY OF α-PINENO ASSOCIATED WITH THE LED DEVICE

• Autor(a) principal: Nicolau, Gabriella Souza
• Data de Publicação: 2022
• Outros Autores: Monteiro, Maria de Fátima Guedes, Sousa Júnior, Dárcio Luiz de, Marques, Ana Emília Formiga, Aquino, Pedro Everson Alexandre de, Ferreira, Sarah de Sousa, Marinho, Aline Diogo, Saraiva, Cícero Roberto Nascimento, Leandro, Maria Karollyna do Nascimento Silva, Silveira, Zildene de Sousa, Silva, Rakel Olinda Macedo da, Leandro, Lívia Maria Garcia
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Revista UniVap (online)
• Texto Completo: https://revista.univap.br/index.php/revistaunivap/article/view/2550
• topic: Resistência bacteriana; Antibióticos; Produtos naturais; Análise microbiológica.; Atividade antibacteriana do α-PINENO associado a luz de LED; Bacterial resistance; Antibiotics; Natural products; Microbiological analysis

The abuse of drugs and their indiscriminate sale are one of the main factors for bacterial resistance, which is a serious health problem. Essential oils are a source of bioactive compounds that may have antimicrobial properties. In this context, α-pinene stands out, a monoterpene that can be extracted from essential oils of plants and has medicinal action. Thus, the present work aims to evaluate the antimicrobial and modulating activity of α-pinene when associated with the Light Emitting Diodes (LED) apparatus against multiresistant bacterial strains. For this purpose, the gaseous contact technique and modulation with antibiotics and blue LED light were used to determine the antimicrobial activity. The minimum inhibitory concentration (MIC) of the α-pinene was ≥ 1024 µg/mL. Possible synergism occurred between α-pinene associated with antibiotics and LED light of the class of Quinolones (Norfloxacin, Ciprofloxacin), Aminoglycosides (Gentamicin, Amikacin) and Beta Lactamic (Penicillin G and Oxacillin) that showed inhibitory potential against multidrug-resistant strains of Staphylococcus aureus and Escherichia coli. The results indicate that the α-pinene has a synergistic action when associated with conventional antibiotics, such as amikacin, which satisfactorily inhibited E. coli and oxacillin, which inhibited S. aureus. In this sense, α-pinene may be a compound with beneficial effects for the treatment of bacterial infections related to resistant strains.