Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review

Detalhes bibliográficos
Autor(a) principal: Peng, Mengyuan
Data de Publicação: 2021
Outros Autores: Guo, Xiaozhong, Yi, Fangfang, Romeiro, Fernando Gomes [UNESP], Mancuso, Andrea, Qi, Xingshun
Tipo de documento: Conjunto de dados
Idioma: eng
Título da fonte: Repositório Institucional da UNESP (dados de pesquisa)
Texto Completo: http://dx.doi.org/10.1007/s12325-021-01912-6
http://hdl.handle.net/11449/229520
Resumo: Gastric antral vascular ectasia (GAVE) is an uncommon clinical entity leading to recurrent gastrointestinal bleeding. There is no consensus regarding treatment of GAVE. Endoscopic therapy is the preferred treatment option, but has a fairly high recurrence rate. Surgical resection can completely resolve GAVE, but is invasive with a relatively high risk of postoperative complications. Recently, the role of pharmacotherapy for GAVE has been recognized. However, the evidence is limited to scattered case reports or small case series. This review comprehensively summarizes the efficacy and side effects of drugs commonly used for the treatment of GAVE, including octreotide, cyproheptadine, cyclophosphamide, prednisolone, estrogen-progesterone, thalidomide, bevacizumab, and tranexamic acid.
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spelling Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative ReviewGastric antral vascular ectasiaGastrointestinal bleedingPathogenesisPharmacotherapyRefractory anemiaGastric antral vascular ectasia (GAVE) is an uncommon clinical entity leading to recurrent gastrointestinal bleeding. There is no consensus regarding treatment of GAVE. Endoscopic therapy is the preferred treatment option, but has a fairly high recurrence rate. Surgical resection can completely resolve GAVE, but is invasive with a relatively high risk of postoperative complications. Recently, the role of pharmacotherapy for GAVE has been recognized. However, the evidence is limited to scattered case reports or small case series. This review comprehensively summarizes the efficacy and side effects of drugs commonly used for the treatment of GAVE, including octreotide, cyproheptadine, cyclophosphamide, prednisolone, estrogen-progesterone, thalidomide, bevacizumab, and tranexamic acid.Department of Gastroenterology General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua RoadPostgraduate College Jinzhou Medical UniversityDepartment of Internal Medicine Botucatu Medical School Universidade Estadual Paulista (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Distrito de Rubião Jr.Medicina Interna 1 ARNAS Civico Di Cristina Benfratelli, Piazzale Leotta 4Department of Internal Medicine Botucatu Medical School Universidade Estadual Paulista (UNESP), Av. Prof. Mário Rubens Guimarães Montenegro, s/n, Distrito de Rubião Jr.General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area)Jinzhou Medical UniversityUniversidade Estadual Paulista (UNESP)BenfratelliPeng, MengyuanGuo, XiaozhongYi, FangfangRomeiro, Fernando Gomes [UNESP]Mancuso, AndreaQi, Xingshun2022-04-29T08:33:04Z2022-04-29T08:33:04Z2021-10-01Resenhainfo:eu-repo/semantics/datasetinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/dataset5065-5077http://dx.doi.org/10.1007/s12325-021-01912-6Advances in Therapy, v. 38, n. 10, p. 5065-5077, 2021.1865-86520741-238Xhttp://hdl.handle.net/11449/22952010.1007/s12325-021-01912-62-s2.0-85114894524Scopusreponame:Repositório Institucional da UNESP (dados de pesquisa)instname:Universidade Estadual Paulista (UNESP)instacron:UNSPengAdvances in Therapyinfo:eu-repo/semantics/openAccess2024-08-14T17:37:34Zoai:repositorio.unesp.br:11449/229520Repositório de Dados de PesquisaPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:2024-08-14T17:37:34Repositório Institucional da UNESP (dados de pesquisa) - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review
title Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review
spellingShingle Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review
Peng, Mengyuan
Gastric antral vascular ectasia
Gastrointestinal bleeding
Pathogenesis
Pharmacotherapy
Refractory anemia
title_short Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review
title_full Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review
title_fullStr Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review
title_full_unstemmed Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review
title_sort Pharmacotherapy for the Treatment of Gastric Antral Vascular Ectasia: A Narrative Review
author Peng, Mengyuan
author_facet Peng, Mengyuan
Guo, Xiaozhong
Yi, Fangfang
Romeiro, Fernando Gomes [UNESP]
Mancuso, Andrea
Qi, Xingshun
author_role author
author2 Guo, Xiaozhong
Yi, Fangfang
Romeiro, Fernando Gomes [UNESP]
Mancuso, Andrea
Qi, Xingshun
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area)
Jinzhou Medical University
Universidade Estadual Paulista (UNESP)
Benfratelli
dc.contributor.author.fl_str_mv Peng, Mengyuan
Guo, Xiaozhong
Yi, Fangfang
Romeiro, Fernando Gomes [UNESP]
Mancuso, Andrea
Qi, Xingshun
dc.subject.por.fl_str_mv Gastric antral vascular ectasia
Gastrointestinal bleeding
Pathogenesis
Pharmacotherapy
Refractory anemia
topic Gastric antral vascular ectasia
Gastrointestinal bleeding
Pathogenesis
Pharmacotherapy
Refractory anemia
description Gastric antral vascular ectasia (GAVE) is an uncommon clinical entity leading to recurrent gastrointestinal bleeding. There is no consensus regarding treatment of GAVE. Endoscopic therapy is the preferred treatment option, but has a fairly high recurrence rate. Surgical resection can completely resolve GAVE, but is invasive with a relatively high risk of postoperative complications. Recently, the role of pharmacotherapy for GAVE has been recognized. However, the evidence is limited to scattered case reports or small case series. This review comprehensively summarizes the efficacy and side effects of drugs commonly used for the treatment of GAVE, including octreotide, cyproheptadine, cyclophosphamide, prednisolone, estrogen-progesterone, thalidomide, bevacizumab, and tranexamic acid.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-01
2022-04-29T08:33:04Z
2022-04-29T08:33:04Z
dc.type.driver.fl_str_mv Resenha
info:eu-repo/semantics/dataset
info:eu-repo/semantics/publishedVersion
dc.type.driver.none.fl_str_mv info:eu-repo/semantics/dataset
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status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s12325-021-01912-6
Advances in Therapy, v. 38, n. 10, p. 5065-5077, 2021.
1865-8652
0741-238X
http://hdl.handle.net/11449/229520
10.1007/s12325-021-01912-6
2-s2.0-85114894524
url http://dx.doi.org/10.1007/s12325-021-01912-6
http://hdl.handle.net/11449/229520
identifier_str_mv Advances in Therapy, v. 38, n. 10, p. 5065-5077, 2021.
1865-8652
0741-238X
10.1007/s12325-021-01912-6
2-s2.0-85114894524
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Advances in Therapy
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5065-5077
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP (dados de pesquisa)
instname:Universidade Estadual Paulista (UNESP)
instacron:UNSP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNSP
institution UNSP
reponame_str Repositório Institucional da UNESP (dados de pesquisa)
collection Repositório Institucional da UNESP (dados de pesquisa)
repository.name.fl_str_mv Repositório Institucional da UNESP (dados de pesquisa) - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
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