Comparison of caffeine-induced locomotor activity between adolescent and adult rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.ejphar.2011.03.052 http://hdl.handle.net/11449/8131 |
Resumo: | Caffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimulant or depressant effects in adolescent and adult rats. Adolescent (37-40 days old) or adult (70-74 days old) Wistar rats were tested for stimulant and depressant caffeine effects in two different experiments. The first was designed to evaluate the locomotor effect of caffeine in habituated rats. To this end, rats were previously habituated to test environment and had their locomotor activity registered following i.p. injections of vehicle or caffeine (3, 10, 30, 60 or 120 mg/kg). In the second experiment adolescent or adult rats were not habituated to the test environment and their locomotor activity was registered following i.p. injections of vehicle or caffeine (30, 60 or 120 mg/kg). In both experiments caffeine-induced a biphasic effect, with stimulation in small to moderate drug doses and no effect or locomotor depression in higher caffeine doses. Moreover, caffeine-induced locomotor stimulation was higher in adolescent than adult rats. Also, locomotor depression was only revealed in adult rats non-habituated to the test environment. These results suggest that adult and adolescent respond differently to caffeine indicating the need of more studies on the effects of caffeine in animals' models of adolescence. (C) 2011 Elsevier B.V. All rights reserved. |
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Comparison of caffeine-induced locomotor activity between adolescent and adult ratsCaffeineAdolescenceLocomotor activityPsychostimulantCaffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimulant or depressant effects in adolescent and adult rats. Adolescent (37-40 days old) or adult (70-74 days old) Wistar rats were tested for stimulant and depressant caffeine effects in two different experiments. The first was designed to evaluate the locomotor effect of caffeine in habituated rats. To this end, rats were previously habituated to test environment and had their locomotor activity registered following i.p. injections of vehicle or caffeine (3, 10, 30, 60 or 120 mg/kg). In the second experiment adolescent or adult rats were not habituated to the test environment and their locomotor activity was registered following i.p. injections of vehicle or caffeine (30, 60 or 120 mg/kg). In both experiments caffeine-induced a biphasic effect, with stimulation in small to moderate drug doses and no effect or locomotor depression in higher caffeine doses. Moreover, caffeine-induced locomotor stimulation was higher in adolescent than adult rats. Also, locomotor depression was only revealed in adult rats non-habituated to the test environment. These results suggest that adult and adolescent respond differently to caffeine indicating the need of more studies on the effects of caffeine in animals' models of adolescence. (C) 2011 Elsevier B.V. All rights reserved.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Estadual Paulista, Sch Pharmaceut Sci, Pharmacol Lab, UNESP, BR-14801902 Araraquara, SP, BrazilUniversidade Federal de Uberlândia (UFU), Inst Biomed Sci, BR-38400902 Uberlandia, MG, BrazilUniversidade Federal de São Carlos (UFSCar), Interinst Grad Program Physiol Sci, BR-13560 São Carlos, SP, BrazilUniv Estadual Paulista, Sch Pharmaceut Sci, Pharmacol Lab, UNESP, BR-14801902 Araraquara, SP, BrazilElsevier B.V.Universidade Estadual Paulista (Unesp)Universidade Federal de Uberlândia (UFU)Universidade Federal de São Carlos (UFSCar)Marin, Marcelo Tadeu [UNESP]Zancheta, Roberta [UNESP]Paro, Ana H. [UNESP]Possi, Ana P. M. [UNESP]Cruz, Fabio C. [UNESP]Planeta, Cleopatra da Silva [UNESP]2014-05-20T13:25:36Z2014-05-20T13:25:36Z2011-06-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article363-367application/pdfhttp://dx.doi.org/10.1016/j.ejphar.2011.03.052European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 660, n. 2-3, p. 363-367, 2011.0014-2999http://hdl.handle.net/11449/813110.1016/j.ejphar.2011.03.052WOS:000291623600017WOS000291623600017.pdf251476254528094279204388025397270000-0002-1378-6327Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Pharmacology3.0401,057info:eu-repo/semantics/openAccess2024-06-24T14:51:51Zoai:repositorio.unesp.br:11449/8131Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:46:15.242167Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats |
title |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats |
spellingShingle |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats Marin, Marcelo Tadeu [UNESP] Caffeine Adolescence Locomotor activity Psychostimulant |
title_short |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats |
title_full |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats |
title_fullStr |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats |
title_full_unstemmed |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats |
title_sort |
Comparison of caffeine-induced locomotor activity between adolescent and adult rats |
author |
Marin, Marcelo Tadeu [UNESP] |
author_facet |
Marin, Marcelo Tadeu [UNESP] Zancheta, Roberta [UNESP] Paro, Ana H. [UNESP] Possi, Ana P. M. [UNESP] Cruz, Fabio C. [UNESP] Planeta, Cleopatra da Silva [UNESP] |
author_role |
author |
author2 |
Zancheta, Roberta [UNESP] Paro, Ana H. [UNESP] Possi, Ana P. M. [UNESP] Cruz, Fabio C. [UNESP] Planeta, Cleopatra da Silva [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Uberlândia (UFU) Universidade Federal de São Carlos (UFSCar) |
dc.contributor.author.fl_str_mv |
Marin, Marcelo Tadeu [UNESP] Zancheta, Roberta [UNESP] Paro, Ana H. [UNESP] Possi, Ana P. M. [UNESP] Cruz, Fabio C. [UNESP] Planeta, Cleopatra da Silva [UNESP] |
dc.subject.por.fl_str_mv |
Caffeine Adolescence Locomotor activity Psychostimulant |
topic |
Caffeine Adolescence Locomotor activity Psychostimulant |
description |
Caffeine is the psychostimulant drug most consumed in the world. This drug is present in food, beverages and medicines marketed for individuals of all ages. In spite of this, caffeine effects on adolescents are poorly understood. The aim of this study was to evaluate the differences on caffeine-induced locomotor stimulant or depressant effects in adolescent and adult rats. Adolescent (37-40 days old) or adult (70-74 days old) Wistar rats were tested for stimulant and depressant caffeine effects in two different experiments. The first was designed to evaluate the locomotor effect of caffeine in habituated rats. To this end, rats were previously habituated to test environment and had their locomotor activity registered following i.p. injections of vehicle or caffeine (3, 10, 30, 60 or 120 mg/kg). In the second experiment adolescent or adult rats were not habituated to the test environment and their locomotor activity was registered following i.p. injections of vehicle or caffeine (30, 60 or 120 mg/kg). In both experiments caffeine-induced a biphasic effect, with stimulation in small to moderate drug doses and no effect or locomotor depression in higher caffeine doses. Moreover, caffeine-induced locomotor stimulation was higher in adolescent than adult rats. Also, locomotor depression was only revealed in adult rats non-habituated to the test environment. These results suggest that adult and adolescent respond differently to caffeine indicating the need of more studies on the effects of caffeine in animals' models of adolescence. (C) 2011 Elsevier B.V. All rights reserved. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-06-25 2014-05-20T13:25:36Z 2014-05-20T13:25:36Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.ejphar.2011.03.052 European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 660, n. 2-3, p. 363-367, 2011. 0014-2999 http://hdl.handle.net/11449/8131 10.1016/j.ejphar.2011.03.052 WOS:000291623600017 WOS000291623600017.pdf 2514762545280942 7920438802539727 0000-0002-1378-6327 |
url |
http://dx.doi.org/10.1016/j.ejphar.2011.03.052 http://hdl.handle.net/11449/8131 |
identifier_str_mv |
European Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 660, n. 2-3, p. 363-367, 2011. 0014-2999 10.1016/j.ejphar.2011.03.052 WOS:000291623600017 WOS000291623600017.pdf 2514762545280942 7920438802539727 0000-0002-1378-6327 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Pharmacology 3.040 1,057 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
363-367 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128977390272512 |