Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0250128 http://hdl.handle.net/11449/206344 |
Resumo: | BACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease. OBJECTIVE: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease. DESIGN: A quasi-randomized prospective controlled trial. SETTING: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors. PARTICIPANTS: Twenty-seven adult outpatients with a sickle cell disease diagnosis. INTERVENTIONS: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13). MAIN OUTCOME MEASURES: Echocardiographic and treadmill test parameters. RESULTS: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E' wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program. CONCLUSION: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients. |
id |
UNSP_017867ac2f91135052bb79fffb84ac63 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/206344 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell diseaseBACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease. OBJECTIVE: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease. DESIGN: A quasi-randomized prospective controlled trial. SETTING: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors. PARTICIPANTS: Twenty-seven adult outpatients with a sickle cell disease diagnosis. INTERVENTIONS: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13). MAIN OUTCOME MEASURES: Echocardiographic and treadmill test parameters. RESULTS: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E' wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program. CONCLUSION: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients.Department of Internal Medicine Sao Paulo State University Julio de Mesquita Filho-UnespDepartment of Physiotherapy Federal University of Sao Carlos-UFSCarDepartment of Medicine Federal University of Sao Carlos-UFSCarDepartment of Internal Medicine Sao Paulo State University Julio de Mesquita Filho-UnespUniversidade Estadual Paulista (Unesp)Universidade Federal de São Carlos (UFSCar)de Araujo Junior, Jonas Alves [UNESP]Antonelli Rossi, Daniele Andreza [UNESP]Carneiro Valadão, Taina Fabri [UNESP]Milan-Mattos, Juliana CristinaCatai, Aparecida MariaSato, Tatiana de OliveiraHueb, Joao Carlos [UNESP]Zanati Bazan, Silmeia Garcia [UNESP]Hokama, Paula Oliveira Montandon [UNESP]Hokama, Newton Key [UNESP]Roscani, Meliza Goi [UNESP]2021-06-25T10:30:28Z2021-06-25T10:30:28Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlee0250128http://dx.doi.org/10.1371/journal.pone.0250128PloS one, v. 16, n. 5, p. e0250128-, 2021.1932-6203http://hdl.handle.net/11449/20634410.1371/journal.pone.02501282-s2.0-85105838700Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPloS oneinfo:eu-repo/semantics/openAccess2021-10-23T03:22:09Zoai:repositorio.unesp.br:11449/206344Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:51:52.974812Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease |
title |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease |
spellingShingle |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease de Araujo Junior, Jonas Alves [UNESP] |
title_short |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease |
title_full |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease |
title_fullStr |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease |
title_full_unstemmed |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease |
title_sort |
Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease |
author |
de Araujo Junior, Jonas Alves [UNESP] |
author_facet |
de Araujo Junior, Jonas Alves [UNESP] Antonelli Rossi, Daniele Andreza [UNESP] Carneiro Valadão, Taina Fabri [UNESP] Milan-Mattos, Juliana Cristina Catai, Aparecida Maria Sato, Tatiana de Oliveira Hueb, Joao Carlos [UNESP] Zanati Bazan, Silmeia Garcia [UNESP] Hokama, Paula Oliveira Montandon [UNESP] Hokama, Newton Key [UNESP] Roscani, Meliza Goi [UNESP] |
author_role |
author |
author2 |
Antonelli Rossi, Daniele Andreza [UNESP] Carneiro Valadão, Taina Fabri [UNESP] Milan-Mattos, Juliana Cristina Catai, Aparecida Maria Sato, Tatiana de Oliveira Hueb, Joao Carlos [UNESP] Zanati Bazan, Silmeia Garcia [UNESP] Hokama, Paula Oliveira Montandon [UNESP] Hokama, Newton Key [UNESP] Roscani, Meliza Goi [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de São Carlos (UFSCar) |
dc.contributor.author.fl_str_mv |
de Araujo Junior, Jonas Alves [UNESP] Antonelli Rossi, Daniele Andreza [UNESP] Carneiro Valadão, Taina Fabri [UNESP] Milan-Mattos, Juliana Cristina Catai, Aparecida Maria Sato, Tatiana de Oliveira Hueb, Joao Carlos [UNESP] Zanati Bazan, Silmeia Garcia [UNESP] Hokama, Paula Oliveira Montandon [UNESP] Hokama, Newton Key [UNESP] Roscani, Meliza Goi [UNESP] |
description |
BACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease. OBJECTIVE: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease. DESIGN: A quasi-randomized prospective controlled trial. SETTING: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors. PARTICIPANTS: Twenty-seven adult outpatients with a sickle cell disease diagnosis. INTERVENTIONS: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13). MAIN OUTCOME MEASURES: Echocardiographic and treadmill test parameters. RESULTS: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E' wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program. CONCLUSION: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:30:28Z 2021-06-25T10:30:28Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0250128 PloS one, v. 16, n. 5, p. e0250128-, 2021. 1932-6203 http://hdl.handle.net/11449/206344 10.1371/journal.pone.0250128 2-s2.0-85105838700 |
url |
http://dx.doi.org/10.1371/journal.pone.0250128 http://hdl.handle.net/11449/206344 |
identifier_str_mv |
PloS one, v. 16, n. 5, p. e0250128-, 2021. 1932-6203 10.1371/journal.pone.0250128 2-s2.0-85105838700 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PloS one |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
e0250128 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129559475781632 |