Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease

Detalhes bibliográficos
Autor(a) principal: de Araujo Junior, Jonas Alves [UNESP]
Data de Publicação: 2021
Outros Autores: Antonelli Rossi, Daniele Andreza [UNESP], Carneiro Valadão, Taina Fabri [UNESP], Milan-Mattos, Juliana Cristina, Catai, Aparecida Maria, Sato, Tatiana de Oliveira, Hueb, Joao Carlos [UNESP], Zanati Bazan, Silmeia Garcia [UNESP], Hokama, Paula Oliveira Montandon [UNESP], Hokama, Newton Key [UNESP], Roscani, Meliza Goi [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1371/journal.pone.0250128
http://hdl.handle.net/11449/206344
Resumo: BACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease. OBJECTIVE: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease. DESIGN: A quasi-randomized prospective controlled trial. SETTING: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors. PARTICIPANTS: Twenty-seven adult outpatients with a sickle cell disease diagnosis. INTERVENTIONS: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13). MAIN OUTCOME MEASURES: Echocardiographic and treadmill test parameters. RESULTS: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E' wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program. CONCLUSION: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients.
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spelling Cardiovascular benefits of a home-based exercise program in patients with sickle cell diseaseBACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease. OBJECTIVE: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease. DESIGN: A quasi-randomized prospective controlled trial. SETTING: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors. PARTICIPANTS: Twenty-seven adult outpatients with a sickle cell disease diagnosis. INTERVENTIONS: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13). MAIN OUTCOME MEASURES: Echocardiographic and treadmill test parameters. RESULTS: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E' wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program. CONCLUSION: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients.Department of Internal Medicine Sao Paulo State University Julio de Mesquita Filho-UnespDepartment of Physiotherapy Federal University of Sao Carlos-UFSCarDepartment of Medicine Federal University of Sao Carlos-UFSCarDepartment of Internal Medicine Sao Paulo State University Julio de Mesquita Filho-UnespUniversidade Estadual Paulista (Unesp)Universidade Federal de São Carlos (UFSCar)de Araujo Junior, Jonas Alves [UNESP]Antonelli Rossi, Daniele Andreza [UNESP]Carneiro Valadão, Taina Fabri [UNESP]Milan-Mattos, Juliana CristinaCatai, Aparecida MariaSato, Tatiana de OliveiraHueb, Joao Carlos [UNESP]Zanati Bazan, Silmeia Garcia [UNESP]Hokama, Paula Oliveira Montandon [UNESP]Hokama, Newton Key [UNESP]Roscani, Meliza Goi [UNESP]2021-06-25T10:30:28Z2021-06-25T10:30:28Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlee0250128http://dx.doi.org/10.1371/journal.pone.0250128PloS one, v. 16, n. 5, p. e0250128-, 2021.1932-6203http://hdl.handle.net/11449/20634410.1371/journal.pone.02501282-s2.0-85105838700Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengPloS oneinfo:eu-repo/semantics/openAccess2021-10-23T03:22:09Zoai:repositorio.unesp.br:11449/206344Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T23:51:52.974812Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
spellingShingle Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
de Araujo Junior, Jonas Alves [UNESP]
title_short Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_full Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_fullStr Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_full_unstemmed Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
title_sort Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease
author de Araujo Junior, Jonas Alves [UNESP]
author_facet de Araujo Junior, Jonas Alves [UNESP]
Antonelli Rossi, Daniele Andreza [UNESP]
Carneiro Valadão, Taina Fabri [UNESP]
Milan-Mattos, Juliana Cristina
Catai, Aparecida Maria
Sato, Tatiana de Oliveira
Hueb, Joao Carlos [UNESP]
Zanati Bazan, Silmeia Garcia [UNESP]
Hokama, Paula Oliveira Montandon [UNESP]
Hokama, Newton Key [UNESP]
Roscani, Meliza Goi [UNESP]
author_role author
author2 Antonelli Rossi, Daniele Andreza [UNESP]
Carneiro Valadão, Taina Fabri [UNESP]
Milan-Mattos, Juliana Cristina
Catai, Aparecida Maria
Sato, Tatiana de Oliveira
Hueb, Joao Carlos [UNESP]
Zanati Bazan, Silmeia Garcia [UNESP]
Hokama, Paula Oliveira Montandon [UNESP]
Hokama, Newton Key [UNESP]
Roscani, Meliza Goi [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade Federal de São Carlos (UFSCar)
dc.contributor.author.fl_str_mv de Araujo Junior, Jonas Alves [UNESP]
Antonelli Rossi, Daniele Andreza [UNESP]
Carneiro Valadão, Taina Fabri [UNESP]
Milan-Mattos, Juliana Cristina
Catai, Aparecida Maria
Sato, Tatiana de Oliveira
Hueb, Joao Carlos [UNESP]
Zanati Bazan, Silmeia Garcia [UNESP]
Hokama, Paula Oliveira Montandon [UNESP]
Hokama, Newton Key [UNESP]
Roscani, Meliza Goi [UNESP]
description BACKGROUND: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease. OBJECTIVE: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease. DESIGN: A quasi-randomized prospective controlled trial. SETTING: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors. PARTICIPANTS: Twenty-seven adult outpatients with a sickle cell disease diagnosis. INTERVENTIONS: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13). MAIN OUTCOME MEASURES: Echocardiographic and treadmill test parameters. RESULTS: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E' wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program. CONCLUSION: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients.
publishDate 2021
dc.date.none.fl_str_mv 2021-06-25T10:30:28Z
2021-06-25T10:30:28Z
2021-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1371/journal.pone.0250128
PloS one, v. 16, n. 5, p. e0250128-, 2021.
1932-6203
http://hdl.handle.net/11449/206344
10.1371/journal.pone.0250128
2-s2.0-85105838700
url http://dx.doi.org/10.1371/journal.pone.0250128
http://hdl.handle.net/11449/206344
identifier_str_mv PloS one, v. 16, n. 5, p. e0250128-, 2021.
1932-6203
10.1371/journal.pone.0250128
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dc.language.iso.fl_str_mv eng
language eng
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reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
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