Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae)
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://www.znaturforsch.com/ac/v64c/c64c.htm http://hdl.handle.net/11449/26059 |
Resumo: | In the course of our continuous search for bioactive metabolites from endophytic fungi living in plants from the Brazilian flora, leaves of Alibertia macrophylla (Rubiaceae) were submitted to isolation of endophytes, and two species of Penicillium were isolated. The acetonitrile fraction obtained in corn from a culture of Penicillium sp.1 afforded orcinol (1). on the other hand, Penicillium sp.1 cultivated in potato-dextrose-broth furnished two different compounds, cyclo-(L-Pro-L-Val) (2) and uracil (3). The chromatographic fractionation of the acetonitrile fraction obtained from Penicillium sp.2 led to three dihydroisocoumarins, 4-hydroxymellein (4), 8-methoxymellein (5) and 5-hydroxymellein (6). Compounds 5 and 6 were obtained from the Penicillium genus for the first time. Additionally, metabolites 1-6 were evaluated for their antifungal and acetylcholinesterase (AChE) inhibitory activities. The most active compounds 1. and 4 exhibited detection limits of 5.00 and 10.0 mu g against Cladosporium. cladosporioides and C. sphaerospermum, respectively. Compound 2 showed a detection limit of 10.0 mu g, displaying potent AChE inhibitory activity. |
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Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae)PenicilliumAlibertia macrophyllaEndophytic FungiAcetylcholinesteraseIn the course of our continuous search for bioactive metabolites from endophytic fungi living in plants from the Brazilian flora, leaves of Alibertia macrophylla (Rubiaceae) were submitted to isolation of endophytes, and two species of Penicillium were isolated. The acetonitrile fraction obtained in corn from a culture of Penicillium sp.1 afforded orcinol (1). on the other hand, Penicillium sp.1 cultivated in potato-dextrose-broth furnished two different compounds, cyclo-(L-Pro-L-Val) (2) and uracil (3). The chromatographic fractionation of the acetonitrile fraction obtained from Penicillium sp.2 led to three dihydroisocoumarins, 4-hydroxymellein (4), 8-methoxymellein (5) and 5-hydroxymellein (6). Compounds 5 and 6 were obtained from the Penicillium genus for the first time. Additionally, metabolites 1-6 were evaluated for their antifungal and acetylcholinesterase (AChE) inhibitory activities. The most active compounds 1. and 4 exhibited detection limits of 5.00 and 10.0 mu g against Cladosporium. cladosporioides and C. sphaerospermum, respectively. Compound 2 showed a detection limit of 10.0 mu g, displaying potent AChE inhibitory activity.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Univ Estadual Paulista, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Dept Quim Organ, Inst Quim, BR-14800900 São Paulo, BrazilUniv Fed Sergipe, BR-49500000 Itabaiana, Sergipe, BrazilInst Bot, Secao Fisiol & Bioquim Plantas, BR-04301902 São Paulo, BrazilUniv Estadual Paulista, Nucleo Bioensaios Biossintese & Ecofisiol Prod Na, Dept Quim Organ, Inst Quim, BR-14800900 São Paulo, BrazilFAPESP: 03/02176-7Verlag Z NaturforschUniversidade Estadual Paulista (Unesp)Universidade Federal de Sergipe (UFS)Instituto de BotânicaOliveira, Camila M. [UNESP]Silva, Geraldo H.Regasini, Luis O. [UNESP]Zanardi, Lisineia M. [UNESP]Evangelista, Alana H. [UNESP]Young, Maria C. M.Bolzani, Vanderlan da Silva [UNESP]Araújo, Angela Regina [UNESP]2014-05-20T14:20:11Z2014-05-20T14:20:11Z2009-11-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article824-830application/pdfhttp://www.znaturforsch.com/ac/v64c/c64c.htmZeitschrift Fur Naturforschung Section C-a Journal of Biosciences. Tubingen: Verlag Z Naturforsch, v. 64, n. 11-12, p. 824-830, 2009.0939-5075http://hdl.handle.net/11449/26059WOS:0002741135000122-s2.0-740491419762-s2.0-74049141976.pdf448408368525167300375790540831600000-0001-7616-9652Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengZeitschrift fur Naturforschung - Section C Journal of Biosciences0.8820,288info:eu-repo/semantics/openAccess2023-12-27T06:22:08Zoai:repositorio.unesp.br:11449/26059Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:27:35.618421Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) |
title |
Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) |
spellingShingle |
Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) Oliveira, Camila M. [UNESP] Penicillium Alibertia macrophylla Endophytic Fungi Acetylcholinesterase |
title_short |
Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) |
title_full |
Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) |
title_fullStr |
Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) |
title_full_unstemmed |
Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) |
title_sort |
Bioactive Metabolites Produced by Penicillium sp.1 and sp.2, Two Endophytes Associated with Alibertia macrophylla (Rubiaceae) |
author |
Oliveira, Camila M. [UNESP] |
author_facet |
Oliveira, Camila M. [UNESP] Silva, Geraldo H. Regasini, Luis O. [UNESP] Zanardi, Lisineia M. [UNESP] Evangelista, Alana H. [UNESP] Young, Maria C. M. Bolzani, Vanderlan da Silva [UNESP] Araújo, Angela Regina [UNESP] |
author_role |
author |
author2 |
Silva, Geraldo H. Regasini, Luis O. [UNESP] Zanardi, Lisineia M. [UNESP] Evangelista, Alana H. [UNESP] Young, Maria C. M. Bolzani, Vanderlan da Silva [UNESP] Araújo, Angela Regina [UNESP] |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Sergipe (UFS) Instituto de Botânica |
dc.contributor.author.fl_str_mv |
Oliveira, Camila M. [UNESP] Silva, Geraldo H. Regasini, Luis O. [UNESP] Zanardi, Lisineia M. [UNESP] Evangelista, Alana H. [UNESP] Young, Maria C. M. Bolzani, Vanderlan da Silva [UNESP] Araújo, Angela Regina [UNESP] |
dc.subject.por.fl_str_mv |
Penicillium Alibertia macrophylla Endophytic Fungi Acetylcholinesterase |
topic |
Penicillium Alibertia macrophylla Endophytic Fungi Acetylcholinesterase |
description |
In the course of our continuous search for bioactive metabolites from endophytic fungi living in plants from the Brazilian flora, leaves of Alibertia macrophylla (Rubiaceae) were submitted to isolation of endophytes, and two species of Penicillium were isolated. The acetonitrile fraction obtained in corn from a culture of Penicillium sp.1 afforded orcinol (1). on the other hand, Penicillium sp.1 cultivated in potato-dextrose-broth furnished two different compounds, cyclo-(L-Pro-L-Val) (2) and uracil (3). The chromatographic fractionation of the acetonitrile fraction obtained from Penicillium sp.2 led to three dihydroisocoumarins, 4-hydroxymellein (4), 8-methoxymellein (5) and 5-hydroxymellein (6). Compounds 5 and 6 were obtained from the Penicillium genus for the first time. Additionally, metabolites 1-6 were evaluated for their antifungal and acetylcholinesterase (AChE) inhibitory activities. The most active compounds 1. and 4 exhibited detection limits of 5.00 and 10.0 mu g against Cladosporium. cladosporioides and C. sphaerospermum, respectively. Compound 2 showed a detection limit of 10.0 mu g, displaying potent AChE inhibitory activity. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-11-01 2014-05-20T14:20:11Z 2014-05-20T14:20:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://www.znaturforsch.com/ac/v64c/c64c.htm Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences. Tubingen: Verlag Z Naturforsch, v. 64, n. 11-12, p. 824-830, 2009. 0939-5075 http://hdl.handle.net/11449/26059 WOS:000274113500012 2-s2.0-74049141976 2-s2.0-74049141976.pdf 4484083685251673 0037579054083160 0000-0001-7616-9652 |
url |
http://www.znaturforsch.com/ac/v64c/c64c.htm http://hdl.handle.net/11449/26059 |
identifier_str_mv |
Zeitschrift Fur Naturforschung Section C-a Journal of Biosciences. Tubingen: Verlag Z Naturforsch, v. 64, n. 11-12, p. 824-830, 2009. 0939-5075 WOS:000274113500012 2-s2.0-74049141976 2-s2.0-74049141976.pdf 4484083685251673 0037579054083160 0000-0001-7616-9652 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Zeitschrift fur Naturforschung - Section C Journal of Biosciences 0.882 0,288 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
824-830 application/pdf |
dc.publisher.none.fl_str_mv |
Verlag Z Naturforsch |
publisher.none.fl_str_mv |
Verlag Z Naturforsch |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129322065592320 |