Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.brainres.2021.147727 http://hdl.handle.net/11449/233855 |
Resumo: | Background: Our understanding of how balance control responds to levodopa over the course of a single day in people with Parkinson's disease (PD) is limited with the majority of studies focused on isolated comparisons of ON vs. OFF levodopa medication. Objective: To evaluate the temporal dynamics of postural control following the first levodopa dose of the day during a challenging standing task in a group of people with PD. Methods: Changes in postural control were evaluated by monitoring cortical activity (covering frontal, motor, parietal and occipital areas), body sway parameters (force platform), and lower limb muscle activity (tibialis anterior and gastrocnemius medialis) in 15 individuals with PD during a semi-tandem standing task. Participants were assessed during two 60 second trials every 30 minutes (ON-30 ON-60 etc.) for 3 hours after the first matinal dose (ON-180). Results: Compared to when tested OFF-medication, cortical activity was increased across all four regions from ON-60 to ON-120 with early increases in alpha and beta band activity observed at ON-30. Levodopa was associated with increased gastrocnemius medialis activity (ON-30 to ON-120) and ankle co-contraction (ON-60 to ON-120). Changes in body sway outcomes (particularly in the anterior-posterior direction) were evident from ON-60 to ON-120. Conclusions: Our results reveal a 60-minute window within which postural control outcomes may be obtained that are different compared to OFF-state and remain stable (from 60-minutes to 120-minutes after levodopa intake). Identifying a window of opportunity for measurement when individuals are optimally medicated is important for observations in a clinical and research setting. |
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Repositório Institucional da UNESP |
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2946 |
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Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's diseaseBrain activityElectroencephalographyMedicationMuscle activityParkinson's diseasePostureBackground: Our understanding of how balance control responds to levodopa over the course of a single day in people with Parkinson's disease (PD) is limited with the majority of studies focused on isolated comparisons of ON vs. OFF levodopa medication. Objective: To evaluate the temporal dynamics of postural control following the first levodopa dose of the day during a challenging standing task in a group of people with PD. Methods: Changes in postural control were evaluated by monitoring cortical activity (covering frontal, motor, parietal and occipital areas), body sway parameters (force platform), and lower limb muscle activity (tibialis anterior and gastrocnemius medialis) in 15 individuals with PD during a semi-tandem standing task. Participants were assessed during two 60 second trials every 30 minutes (ON-30 ON-60 etc.) for 3 hours after the first matinal dose (ON-180). Results: Compared to when tested OFF-medication, cortical activity was increased across all four regions from ON-60 to ON-120 with early increases in alpha and beta band activity observed at ON-30. Levodopa was associated with increased gastrocnemius medialis activity (ON-30 to ON-120) and ankle co-contraction (ON-60 to ON-120). Changes in body sway outcomes (particularly in the anterior-posterior direction) were evident from ON-60 to ON-120. Conclusions: Our results reveal a 60-minute window within which postural control outcomes may be obtained that are different compared to OFF-state and remain stable (from 60-minutes to 120-minutes after levodopa intake). Identifying a window of opportunity for measurement when individuals are optimally medicated is important for observations in a clinical and research setting.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)São Paulo State University (UNESP) School of Sciences Graduate Program in Movement Sciences Department of Physical Education Human Movement Research Laboratory (MOVI-LAB)REVAL Rehabilitation Research Center Faculty of Rehabilitation Sciences Hasselt UniversityTranslational and Clinical Research Institute Faculty of Medical Sciences Newcastle University Newcastle upon TyneSão Paulo State University (UNESP) School of Sciences Graduate Program in Movement Sciences Department of Physical Education Human Movement Research Laboratory (MOVI-LAB)Universidade Estadual Paulista (UNESP)Hasselt UniversityNewcastle University Newcastle upon TyneAraújo-Silva, Fabiana [UNESP]Santinelli, Felipe B. [UNESP]Felipe I. Imaizumi, Luis [UNESP]Silveira, Aline P.B. [UNESP]Vieira, Luiz H.P. [UNESP]Alcock, LisaBarbieri, Fabio A. [UNESP]2022-05-01T11:07:20Z2022-05-01T11:07:20Z2022-01-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.brainres.2021.147727Brain Research, v. 1775.1872-62400006-8993http://hdl.handle.net/11449/23385510.1016/j.brainres.2021.1477272-s2.0-85120310880Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrain Researchinfo:eu-repo/semantics/openAccess2024-04-24T18:52:57Zoai:repositorio.unesp.br:11449/233855Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:20:25.490359Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease |
title |
Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease |
spellingShingle |
Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease Araújo-Silva, Fabiana [UNESP] Brain activity Electroencephalography Medication Muscle activity Parkinson's disease Posture |
title_short |
Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease |
title_full |
Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease |
title_fullStr |
Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease |
title_full_unstemmed |
Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease |
title_sort |
Temporal dynamics of cortical activity and postural control in response to the first levodopa dose of the day in people with Parkinson's disease |
author |
Araújo-Silva, Fabiana [UNESP] |
author_facet |
Araújo-Silva, Fabiana [UNESP] Santinelli, Felipe B. [UNESP] Felipe I. Imaizumi, Luis [UNESP] Silveira, Aline P.B. [UNESP] Vieira, Luiz H.P. [UNESP] Alcock, Lisa Barbieri, Fabio A. [UNESP] |
author_role |
author |
author2 |
Santinelli, Felipe B. [UNESP] Felipe I. Imaizumi, Luis [UNESP] Silveira, Aline P.B. [UNESP] Vieira, Luiz H.P. [UNESP] Alcock, Lisa Barbieri, Fabio A. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Hasselt University Newcastle University Newcastle upon Tyne |
dc.contributor.author.fl_str_mv |
Araújo-Silva, Fabiana [UNESP] Santinelli, Felipe B. [UNESP] Felipe I. Imaizumi, Luis [UNESP] Silveira, Aline P.B. [UNESP] Vieira, Luiz H.P. [UNESP] Alcock, Lisa Barbieri, Fabio A. [UNESP] |
dc.subject.por.fl_str_mv |
Brain activity Electroencephalography Medication Muscle activity Parkinson's disease Posture |
topic |
Brain activity Electroencephalography Medication Muscle activity Parkinson's disease Posture |
description |
Background: Our understanding of how balance control responds to levodopa over the course of a single day in people with Parkinson's disease (PD) is limited with the majority of studies focused on isolated comparisons of ON vs. OFF levodopa medication. Objective: To evaluate the temporal dynamics of postural control following the first levodopa dose of the day during a challenging standing task in a group of people with PD. Methods: Changes in postural control were evaluated by monitoring cortical activity (covering frontal, motor, parietal and occipital areas), body sway parameters (force platform), and lower limb muscle activity (tibialis anterior and gastrocnemius medialis) in 15 individuals with PD during a semi-tandem standing task. Participants were assessed during two 60 second trials every 30 minutes (ON-30 ON-60 etc.) for 3 hours after the first matinal dose (ON-180). Results: Compared to when tested OFF-medication, cortical activity was increased across all four regions from ON-60 to ON-120 with early increases in alpha and beta band activity observed at ON-30. Levodopa was associated with increased gastrocnemius medialis activity (ON-30 to ON-120) and ankle co-contraction (ON-60 to ON-120). Changes in body sway outcomes (particularly in the anterior-posterior direction) were evident from ON-60 to ON-120. Conclusions: Our results reveal a 60-minute window within which postural control outcomes may be obtained that are different compared to OFF-state and remain stable (from 60-minutes to 120-minutes after levodopa intake). Identifying a window of opportunity for measurement when individuals are optimally medicated is important for observations in a clinical and research setting. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T11:07:20Z 2022-05-01T11:07:20Z 2022-01-15 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.brainres.2021.147727 Brain Research, v. 1775. 1872-6240 0006-8993 http://hdl.handle.net/11449/233855 10.1016/j.brainres.2021.147727 2-s2.0-85120310880 |
url |
http://dx.doi.org/10.1016/j.brainres.2021.147727 http://hdl.handle.net/11449/233855 |
identifier_str_mv |
Brain Research, v. 1775. 1872-6240 0006-8993 10.1016/j.brainres.2021.147727 2-s2.0-85120310880 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brain Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128498596839424 |