Spleen tissue changes after restraint stress: effects of aerobic exercise training
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/10253890.2021.1895112 http://hdl.handle.net/11449/206134 |
Resumo: | Inflammation has been described as a prominent mechanism involved in dysfunctions and diseases evoked by chronic stress. Notably, the spleen is an immune organ controlled by sympathetic and glucocorticoid mechanisms, but the impact of chronic stress in the spleen is not entirely understood. Besides, the impact of aerobic exercise training on the effects of chronic stress in the spleen has never been reported. Therefore, this study aimed to assess the changes caused in the spleen by repeated restraint stress and the effect of aerobic exercise training performed after a period of chronic restraint stress in rats. We identified that daily exposure to restraint stress (120 min per session, for 14 consecutive days) increased corticosterone and noradrenaline content, gene expression of glucocorticoid and β2-adrenergic receptors, TNF-α and IL-6 levels, and increased pro-oxidant substances in the spleen. Circulating levels of corticosterone were also increased in chronically stressed animals. Exercise training (1 h a day/5 days per week, for 60 days) increased glucocorticoid receptor gene expression, interleukin (IL)-10 and antioxidant mechanisms in the spleen. Exercise also decreased splenic noradrenaline, tumoral necrosis factor (TNF)-α, and IL-6 contents. Lastly, the effects of repeated restraint stress in the spleen were mitigated in animals subjected to aerobic training. Taken together, the results reported in the present study indicate that aerobic exercise training is a relevant non-pharmacological therapeutic approach to dysfunctions in the spleen caused by a period of stress. |
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Spleen tissue changes after restraint stress: effects of aerobic exercise trainingexerciseglucocorticoidsinflammationoxidative stressRestraint stresssympathetic activityInflammation has been described as a prominent mechanism involved in dysfunctions and diseases evoked by chronic stress. Notably, the spleen is an immune organ controlled by sympathetic and glucocorticoid mechanisms, but the impact of chronic stress in the spleen is not entirely understood. Besides, the impact of aerobic exercise training on the effects of chronic stress in the spleen has never been reported. Therefore, this study aimed to assess the changes caused in the spleen by repeated restraint stress and the effect of aerobic exercise training performed after a period of chronic restraint stress in rats. We identified that daily exposure to restraint stress (120 min per session, for 14 consecutive days) increased corticosterone and noradrenaline content, gene expression of glucocorticoid and β2-adrenergic receptors, TNF-α and IL-6 levels, and increased pro-oxidant substances in the spleen. Circulating levels of corticosterone were also increased in chronically stressed animals. Exercise training (1 h a day/5 days per week, for 60 days) increased glucocorticoid receptor gene expression, interleukin (IL)-10 and antioxidant mechanisms in the spleen. Exercise also decreased splenic noradrenaline, tumoral necrosis factor (TNF)-α, and IL-6 contents. Lastly, the effects of repeated restraint stress in the spleen were mitigated in animals subjected to aerobic training. Taken together, the results reported in the present study indicate that aerobic exercise training is a relevant non-pharmacological therapeutic approach to dysfunctions in the spleen caused by a period of stress.Laboratory of Cardiovascular Investigation and Exercise (LICE) School of Physical Education University of Campinas (UNICAMP)Department of Structural and Functional Biology Institute of Biology University of Campinas (UNICAMP)Department of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP)Department of Drugs and Pharmaceutics School of Pharmaceutical Sciences São Paulo State University (UNESP)Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Feriani, Daniele J.Sousa, Andressa S.Delbin, Maria AndreiaRuberti, Olívia M.Crestani, Carlos C. [UNESP]Rodrigues, Bruno2021-06-25T10:27:04Z2021-06-25T10:27:04Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1080/10253890.2021.1895112Stress.1607-88881025-3890http://hdl.handle.net/11449/20613410.1080/10253890.2021.18951122-s2.0-85103566930Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengStressinfo:eu-repo/semantics/openAccess2021-10-22T21:09:47Zoai:repositorio.unesp.br:11449/206134Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:17:44.326446Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Spleen tissue changes after restraint stress: effects of aerobic exercise training |
title |
Spleen tissue changes after restraint stress: effects of aerobic exercise training |
spellingShingle |
Spleen tissue changes after restraint stress: effects of aerobic exercise training Feriani, Daniele J. exercise glucocorticoids inflammation oxidative stress Restraint stress sympathetic activity |
title_short |
Spleen tissue changes after restraint stress: effects of aerobic exercise training |
title_full |
Spleen tissue changes after restraint stress: effects of aerobic exercise training |
title_fullStr |
Spleen tissue changes after restraint stress: effects of aerobic exercise training |
title_full_unstemmed |
Spleen tissue changes after restraint stress: effects of aerobic exercise training |
title_sort |
Spleen tissue changes after restraint stress: effects of aerobic exercise training |
author |
Feriani, Daniele J. |
author_facet |
Feriani, Daniele J. Sousa, Andressa S. Delbin, Maria Andreia Ruberti, Olívia M. Crestani, Carlos C. [UNESP] Rodrigues, Bruno |
author_role |
author |
author2 |
Sousa, Andressa S. Delbin, Maria Andreia Ruberti, Olívia M. Crestani, Carlos C. [UNESP] Rodrigues, Bruno |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Feriani, Daniele J. Sousa, Andressa S. Delbin, Maria Andreia Ruberti, Olívia M. Crestani, Carlos C. [UNESP] Rodrigues, Bruno |
dc.subject.por.fl_str_mv |
exercise glucocorticoids inflammation oxidative stress Restraint stress sympathetic activity |
topic |
exercise glucocorticoids inflammation oxidative stress Restraint stress sympathetic activity |
description |
Inflammation has been described as a prominent mechanism involved in dysfunctions and diseases evoked by chronic stress. Notably, the spleen is an immune organ controlled by sympathetic and glucocorticoid mechanisms, but the impact of chronic stress in the spleen is not entirely understood. Besides, the impact of aerobic exercise training on the effects of chronic stress in the spleen has never been reported. Therefore, this study aimed to assess the changes caused in the spleen by repeated restraint stress and the effect of aerobic exercise training performed after a period of chronic restraint stress in rats. We identified that daily exposure to restraint stress (120 min per session, for 14 consecutive days) increased corticosterone and noradrenaline content, gene expression of glucocorticoid and β2-adrenergic receptors, TNF-α and IL-6 levels, and increased pro-oxidant substances in the spleen. Circulating levels of corticosterone were also increased in chronically stressed animals. Exercise training (1 h a day/5 days per week, for 60 days) increased glucocorticoid receptor gene expression, interleukin (IL)-10 and antioxidant mechanisms in the spleen. Exercise also decreased splenic noradrenaline, tumoral necrosis factor (TNF)-α, and IL-6 contents. Lastly, the effects of repeated restraint stress in the spleen were mitigated in animals subjected to aerobic training. Taken together, the results reported in the present study indicate that aerobic exercise training is a relevant non-pharmacological therapeutic approach to dysfunctions in the spleen caused by a period of stress. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:27:04Z 2021-06-25T10:27:04Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/10253890.2021.1895112 Stress. 1607-8888 1025-3890 http://hdl.handle.net/11449/206134 10.1080/10253890.2021.1895112 2-s2.0-85103566930 |
url |
http://dx.doi.org/10.1080/10253890.2021.1895112 http://hdl.handle.net/11449/206134 |
identifier_str_mv |
Stress. 1607-8888 1025-3890 10.1080/10253890.2021.1895112 2-s2.0-85103566930 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Stress |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128342136717312 |