Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio)
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.cbi.2018.07.007 http://hdl.handle.net/11449/171225 |
Resumo: | Dyes have been used for more than twenty thousand years in textile, pharmaceutical, food, cosmetic, and photographic industries, among others. Despite their importance in these applications, dyes can be toxic and resistant to many degradation processes used in wastewater treatment plants. Although a large number of dyes have been released in the environments in high amounts, studies into the environmental toxicity of these substances are still scarce. The aim of this study was to evaluate the potential toxic effects of textile dyes Disperse Red 60, Disperse Red 73 and Disperse Red 78 in zebrafish early life stages. To this end, biochemical biomarkers were selected to evaluate non-enzimatic antioxidant (Total Glutathione), antioxidant enzymes (Glutathione S-transferase and Catalase), oxidative stress (lipid peroxidation), neurotransmission (acetylcholinesterase) and energetic metabolism parameters (energy available and energy consumed) after 96 h exposure to these dyes. Our results demonstrated that these disperse dyes induce biochemical alterations in zebrafish embryos at environmental realistic concentrations and that the discharge of these disperse dyes into water bodies should be carefully evaluated. The selected biomarkers were sensitive as early-warning endpoints of disperse dyes toxicity on zebrafish embryos. Implications for risk assessment and indications for future research are discussed. |
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Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio)Cellular energy allocationNeurotoxicityOxidative stressTextile dyesDyes have been used for more than twenty thousand years in textile, pharmaceutical, food, cosmetic, and photographic industries, among others. Despite their importance in these applications, dyes can be toxic and resistant to many degradation processes used in wastewater treatment plants. Although a large number of dyes have been released in the environments in high amounts, studies into the environmental toxicity of these substances are still scarce. The aim of this study was to evaluate the potential toxic effects of textile dyes Disperse Red 60, Disperse Red 73 and Disperse Red 78 in zebrafish early life stages. To this end, biochemical biomarkers were selected to evaluate non-enzimatic antioxidant (Total Glutathione), antioxidant enzymes (Glutathione S-transferase and Catalase), oxidative stress (lipid peroxidation), neurotransmission (acetylcholinesterase) and energetic metabolism parameters (energy available and energy consumed) after 96 h exposure to these dyes. Our results demonstrated that these disperse dyes induce biochemical alterations in zebrafish embryos at environmental realistic concentrations and that the discharge of these disperse dyes into water bodies should be carefully evaluated. The selected biomarkers were sensitive as early-warning endpoints of disperse dyes toxicity on zebrafish embryos. Implications for risk assessment and indications for future research are discussed.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Federación Española de Enfermedades RarasFundació Catalana de TrasplantamentCentro de Estudos Ambientais e Marinhos, Universidade de AveiroSchool of Pharmaceutical Sciences of Ribeirão Preto University of São PauloDepartment of Biology and CESAM University of AveiroCENSE Department of Environmental Sciences and Engineering Faculty of Sciences and Technology New University of Lisbon, Quinta da TorreNEEA/CRHEA/SHS São Carlos Engineering School University of São PauloInstitute of Chemistry-State University “Julio de Mesquita Filho”-UNESPFaculty of Sciences and CESAM University of Lisboa, Campo AlegreNational Institute of Science and Technology for Detection Toxicological Evaluation and Removal of Emerging and Radioactive Contaminants (INCT-DATREM) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Institute of Chemistry-State University “Julio de Mesquita Filho”-UNESPCNPq: 142379/2014-0FAPESP: 2014/14621-0FAPESP: 2016/03281-9FAPESP: 2017/05543-3CAPES: 88881.134597/2016-01Federación Española de Enfermedades Raras: PT2020Fundació Catalana de Trasplantament: SFRH/BPD/109199/2015Centro de Estudos Ambientais e Marinhos, Universidade de Aveiro: UID/AMB/50017Universidade de São Paulo (USP)University of AveiroNew University of LisbonUniversidade Estadual Paulista (Unesp)University of LisboaConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Meireles, GabrielaDaam, Michiel A.Sanches, Ana Letícia MadeiraZanoni, Maria V.B. [UNESP]Soares, Amadeu M.V.M.Gravato, CarlosOliveira, Danielle P. de2018-12-11T16:54:28Z2018-12-11T16:54:28Z2018-08-25info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article94-100application/pdfhttp://dx.doi.org/10.1016/j.cbi.2018.07.007Chemico-Biological Interactions, v. 292, p. 94-100.1872-77860009-2797http://hdl.handle.net/11449/17122510.1016/j.cbi.2018.07.0072-s2.0-850501142552-s2.0-85050114255.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengChemico-Biological Interactions1,033info:eu-repo/semantics/openAccess2023-10-29T06:13:12Zoai:repositorio.unesp.br:11449/171225Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:24:52.244473Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio) |
title |
Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio) |
spellingShingle |
Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio) Meireles, Gabriela Cellular energy allocation Neurotoxicity Oxidative stress Textile dyes |
title_short |
Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio) |
title_full |
Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio) |
title_fullStr |
Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio) |
title_full_unstemmed |
Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio) |
title_sort |
Red disperse dyes (DR 60, DR 73 and DR 78) at environmentally realistic concentrations impact biochemical profile of early life stages of zebrafish (Danio rerio) |
author |
Meireles, Gabriela |
author_facet |
Meireles, Gabriela Daam, Michiel A. Sanches, Ana Letícia Madeira Zanoni, Maria V.B. [UNESP] Soares, Amadeu M.V.M. Gravato, Carlos Oliveira, Danielle P. de |
author_role |
author |
author2 |
Daam, Michiel A. Sanches, Ana Letícia Madeira Zanoni, Maria V.B. [UNESP] Soares, Amadeu M.V.M. Gravato, Carlos Oliveira, Danielle P. de |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) University of Aveiro New University of Lisbon Universidade Estadual Paulista (Unesp) University of Lisboa Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) |
dc.contributor.author.fl_str_mv |
Meireles, Gabriela Daam, Michiel A. Sanches, Ana Letícia Madeira Zanoni, Maria V.B. [UNESP] Soares, Amadeu M.V.M. Gravato, Carlos Oliveira, Danielle P. de |
dc.subject.por.fl_str_mv |
Cellular energy allocation Neurotoxicity Oxidative stress Textile dyes |
topic |
Cellular energy allocation Neurotoxicity Oxidative stress Textile dyes |
description |
Dyes have been used for more than twenty thousand years in textile, pharmaceutical, food, cosmetic, and photographic industries, among others. Despite their importance in these applications, dyes can be toxic and resistant to many degradation processes used in wastewater treatment plants. Although a large number of dyes have been released in the environments in high amounts, studies into the environmental toxicity of these substances are still scarce. The aim of this study was to evaluate the potential toxic effects of textile dyes Disperse Red 60, Disperse Red 73 and Disperse Red 78 in zebrafish early life stages. To this end, biochemical biomarkers were selected to evaluate non-enzimatic antioxidant (Total Glutathione), antioxidant enzymes (Glutathione S-transferase and Catalase), oxidative stress (lipid peroxidation), neurotransmission (acetylcholinesterase) and energetic metabolism parameters (energy available and energy consumed) after 96 h exposure to these dyes. Our results demonstrated that these disperse dyes induce biochemical alterations in zebrafish embryos at environmental realistic concentrations and that the discharge of these disperse dyes into water bodies should be carefully evaluated. The selected biomarkers were sensitive as early-warning endpoints of disperse dyes toxicity on zebrafish embryos. Implications for risk assessment and indications for future research are discussed. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T16:54:28Z 2018-12-11T16:54:28Z 2018-08-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.cbi.2018.07.007 Chemico-Biological Interactions, v. 292, p. 94-100. 1872-7786 0009-2797 http://hdl.handle.net/11449/171225 10.1016/j.cbi.2018.07.007 2-s2.0-85050114255 2-s2.0-85050114255.pdf |
url |
http://dx.doi.org/10.1016/j.cbi.2018.07.007 http://hdl.handle.net/11449/171225 |
identifier_str_mv |
Chemico-Biological Interactions, v. 292, p. 94-100. 1872-7786 0009-2797 10.1016/j.cbi.2018.07.007 2-s2.0-85050114255 2-s2.0-85050114255.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Chemico-Biological Interactions 1,033 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
94-100 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128645267456000 |