Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.bjan.2018.12.011 http://hdl.handle.net/11449/189437 |
Resumo: | Background: Postoperative pain represents an important concern when remifentanil is used for total intravenous anesthesia because of its ultrashort half‐life. Longer acting opioids, such as sufentanil, have been used during induction of remifentanil‐based total intravenous anesthesia as a means to overcome this shortcoming. However, the effectiveness and safety of such strategy still lacks evidence from randomized clinical trials. Hence, we aimed to assess the postoperative analgesic efficacy and safety of a single dose of sufentanil administered during the induction of remifentanil‐based total intravenous anesthesia. Methods: Forty patients, scheduled for elective open abdominal surgery, were randomized to receive remifentanil‐based total intravenous anesthesia with or without a single dose of sufentanil upon induction. We assessed the postoperative morphine consumption administered through a patient‐controlled analgesia pump. Self‐reported pain scores and the occurrence of nausea, vomiting, pruritus, agitation, somnolence and respiratory depression were also assessed up to 2 days after surgery. Results: The mean difference between the sufentanil and control groups regarding morphine consumption in the post‐anesthetic care unit and at 12, 24 and 48 h after surgery were −7.2 mg (95%CI: −12.5 to −2.1, p < 0.001), −3.9 mg (95%CI: −11.9 to 4.7, p = 0.26), −0.6 mg (95%CI: (−12.7 to 12.7, p = 0.80), and −1.8 mg (95%CI: (−11.6 to 15.6, p = 0.94), respectively. Neither self‐reported pain nor the incidence of adverse events were significantly different between groups at any time point. Conclusion: Our findings suggest that the administration of sufentanil during induction of remifentanil‐based total intravenous anesthesia is associated with decreased early postoperative opioid consumption. |
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Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trialSufentanil durante a indução da anestesia intravenosa total à base de remifentanil: ensaio clínico randômicoAcute painOpioidPainTotal intravenous anesthesiaBackground: Postoperative pain represents an important concern when remifentanil is used for total intravenous anesthesia because of its ultrashort half‐life. Longer acting opioids, such as sufentanil, have been used during induction of remifentanil‐based total intravenous anesthesia as a means to overcome this shortcoming. However, the effectiveness and safety of such strategy still lacks evidence from randomized clinical trials. Hence, we aimed to assess the postoperative analgesic efficacy and safety of a single dose of sufentanil administered during the induction of remifentanil‐based total intravenous anesthesia. Methods: Forty patients, scheduled for elective open abdominal surgery, were randomized to receive remifentanil‐based total intravenous anesthesia with or without a single dose of sufentanil upon induction. We assessed the postoperative morphine consumption administered through a patient‐controlled analgesia pump. Self‐reported pain scores and the occurrence of nausea, vomiting, pruritus, agitation, somnolence and respiratory depression were also assessed up to 2 days after surgery. Results: The mean difference between the sufentanil and control groups regarding morphine consumption in the post‐anesthetic care unit and at 12, 24 and 48 h after surgery were −7.2 mg (95%CI: −12.5 to −2.1, p < 0.001), −3.9 mg (95%CI: −11.9 to 4.7, p = 0.26), −0.6 mg (95%CI: (−12.7 to 12.7, p = 0.80), and −1.8 mg (95%CI: (−11.6 to 15.6, p = 0.94), respectively. Neither self‐reported pain nor the incidence of adverse events were significantly different between groups at any time point. Conclusion: Our findings suggest that the administration of sufentanil during induction of remifentanil‐based total intravenous anesthesia is associated with decreased early postoperative opioid consumption.Universidade Federal de Sergipe (UFS)Universidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Medicina InternaQueen's University Department of Anesthesiology and Perioperative MedicineUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de AnestesiologiaUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de Medicina InternaUniversidade Estadual Paulista (UNESP) Faculdade de Medicina de Botucatu Departamento de AnestesiologiaUniversidade Federal de Sergipe (UFS)Universidade Estadual Paulista (Unesp)Queen's UniversityMenezes, Daniel C.Vidal, Edison I.O. [UNESP]Costa, Cesar M. [UNESP]Mizubuti, Glenio B.Ho, Anthony M.H.Barros, Guilherme A.M. [UNESP]Fukushima, Fernanda B. [UNESP]2019-10-06T16:40:39Z2019-10-06T16:40:39Z2019-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article327-334http://dx.doi.org/10.1016/j.bjan.2018.12.011Brazilian Journal of Anesthesiology, v. 69, n. 4, p. 327-334, 2019.1806-907X0034-7094http://hdl.handle.net/11449/18943710.1016/j.bjan.2018.12.0112-s2.0-8506959848292767290871804150000-0002-1573-4678Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengporBrazilian Journal of Anesthesiologyinfo:eu-repo/semantics/openAccess2021-10-23T19:02:03Zoai:repositorio.unesp.br:11449/189437Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T19:02:03Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial Sufentanil durante a indução da anestesia intravenosa total à base de remifentanil: ensaio clínico randômico |
title |
Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial |
spellingShingle |
Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial Menezes, Daniel C. Acute pain Opioid Pain Total intravenous anesthesia |
title_short |
Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial |
title_full |
Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial |
title_fullStr |
Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial |
title_full_unstemmed |
Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial |
title_sort |
Sufentanil during anesthetic induction of remifentanil‐based total intravenous anesthesia: a randomized controlled trial |
author |
Menezes, Daniel C. |
author_facet |
Menezes, Daniel C. Vidal, Edison I.O. [UNESP] Costa, Cesar M. [UNESP] Mizubuti, Glenio B. Ho, Anthony M.H. Barros, Guilherme A.M. [UNESP] Fukushima, Fernanda B. [UNESP] |
author_role |
author |
author2 |
Vidal, Edison I.O. [UNESP] Costa, Cesar M. [UNESP] Mizubuti, Glenio B. Ho, Anthony M.H. Barros, Guilherme A.M. [UNESP] Fukushima, Fernanda B. [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de Sergipe (UFS) Universidade Estadual Paulista (Unesp) Queen's University |
dc.contributor.author.fl_str_mv |
Menezes, Daniel C. Vidal, Edison I.O. [UNESP] Costa, Cesar M. [UNESP] Mizubuti, Glenio B. Ho, Anthony M.H. Barros, Guilherme A.M. [UNESP] Fukushima, Fernanda B. [UNESP] |
dc.subject.por.fl_str_mv |
Acute pain Opioid Pain Total intravenous anesthesia |
topic |
Acute pain Opioid Pain Total intravenous anesthesia |
description |
Background: Postoperative pain represents an important concern when remifentanil is used for total intravenous anesthesia because of its ultrashort half‐life. Longer acting opioids, such as sufentanil, have been used during induction of remifentanil‐based total intravenous anesthesia as a means to overcome this shortcoming. However, the effectiveness and safety of such strategy still lacks evidence from randomized clinical trials. Hence, we aimed to assess the postoperative analgesic efficacy and safety of a single dose of sufentanil administered during the induction of remifentanil‐based total intravenous anesthesia. Methods: Forty patients, scheduled for elective open abdominal surgery, were randomized to receive remifentanil‐based total intravenous anesthesia with or without a single dose of sufentanil upon induction. We assessed the postoperative morphine consumption administered through a patient‐controlled analgesia pump. Self‐reported pain scores and the occurrence of nausea, vomiting, pruritus, agitation, somnolence and respiratory depression were also assessed up to 2 days after surgery. Results: The mean difference between the sufentanil and control groups regarding morphine consumption in the post‐anesthetic care unit and at 12, 24 and 48 h after surgery were −7.2 mg (95%CI: −12.5 to −2.1, p < 0.001), −3.9 mg (95%CI: −11.9 to 4.7, p = 0.26), −0.6 mg (95%CI: (−12.7 to 12.7, p = 0.80), and −1.8 mg (95%CI: (−11.6 to 15.6, p = 0.94), respectively. Neither self‐reported pain nor the incidence of adverse events were significantly different between groups at any time point. Conclusion: Our findings suggest that the administration of sufentanil during induction of remifentanil‐based total intravenous anesthesia is associated with decreased early postoperative opioid consumption. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T16:40:39Z 2019-10-06T16:40:39Z 2019-07-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjan.2018.12.011 Brazilian Journal of Anesthesiology, v. 69, n. 4, p. 327-334, 2019. 1806-907X 0034-7094 http://hdl.handle.net/11449/189437 10.1016/j.bjan.2018.12.011 2-s2.0-85069598482 9276729087180415 0000-0002-1573-4678 |
url |
http://dx.doi.org/10.1016/j.bjan.2018.12.011 http://hdl.handle.net/11449/189437 |
identifier_str_mv |
Brazilian Journal of Anesthesiology, v. 69, n. 4, p. 327-334, 2019. 1806-907X 0034-7094 10.1016/j.bjan.2018.12.011 2-s2.0-85069598482 9276729087180415 0000-0002-1573-4678 |
dc.language.iso.fl_str_mv |
eng por |
language |
eng por |
dc.relation.none.fl_str_mv |
Brazilian Journal of Anesthesiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
327-334 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1803045914956267520 |