A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1038/s41598-020-69979-9 http://hdl.handle.net/11449/197201 |
Resumo: | It is estimated that multiple sclerosis (MS) affects 35,000 Brazilians and 2.5 million individuals worldwide. Many studies have suggested a possible role of metallic elements in the etiology of MS, but their concentration in the blood of MS patients is nonetheless little investigated in Brazil. In this work, these elements were studied through Inductively Coupled Plasma Mass Spectrometry (ICP-MS), whose analysis provides a tool to quantify the concentrations of metal elements in the blood samples of individuals with neurodegenerative disorders. This study aimed to compare the concentration of metallic elements in blood samples from patients with MS and healthy individuals. Blood was collected from 30 patients with multiple sclerosis and compared with the control group. Blood samples were digested in closed vessels using a microwave and ICP-MS was used to determine the concentrations of 12 metallic elements (Ba, Be, Ca, Co, Cr, Cu, Fe, Mg, Mo, Ni, Pb and Zn). In MS patients, we observed a reduction in the concentrations of beryllium, copper, chromium, cobalt, nickel, magnesium and iron. The mean concentration of lead in blood was significantly elevated in the MS group. However, no difference was observed in the concentrations of Mo, Ba, Ca and Zn in blood samples from MS patients and the control group. According to our data, there is a possible role for the concentrations of 8 of the 12 evaluated metallic elements in multiple sclerosis. Abnormalities in transition metals levels in biological matrices have been reported in several neurological diseases. |
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A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MSIt is estimated that multiple sclerosis (MS) affects 35,000 Brazilians and 2.5 million individuals worldwide. Many studies have suggested a possible role of metallic elements in the etiology of MS, but their concentration in the blood of MS patients is nonetheless little investigated in Brazil. In this work, these elements were studied through Inductively Coupled Plasma Mass Spectrometry (ICP-MS), whose analysis provides a tool to quantify the concentrations of metal elements in the blood samples of individuals with neurodegenerative disorders. This study aimed to compare the concentration of metallic elements in blood samples from patients with MS and healthy individuals. Blood was collected from 30 patients with multiple sclerosis and compared with the control group. Blood samples were digested in closed vessels using a microwave and ICP-MS was used to determine the concentrations of 12 metallic elements (Ba, Be, Ca, Co, Cr, Cu, Fe, Mg, Mo, Ni, Pb and Zn). In MS patients, we observed a reduction in the concentrations of beryllium, copper, chromium, cobalt, nickel, magnesium and iron. The mean concentration of lead in blood was significantly elevated in the MS group. However, no difference was observed in the concentrations of Mo, Ba, Ca and Zn in blood samples from MS patients and the control group. According to our data, there is a possible role for the concentrations of 8 of the 12 evaluated metallic elements in multiple sclerosis. Abnormalities in transition metals levels in biological matrices have been reported in several neurological diseases.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Hospital of Clinics-Botucatu Medical School (HC-FMB) of Sao Paulo State University (Unesp), Botucatu CampusSchool of Sciences of Sao Paulo State University, Bauru CampusSao Paulo State Univ, Sch Sci, Dept Phys, Av Eng Luiz Edmundo Carrijo Coube 14-01, BR-17033360 Bauru, SP, BrazilOurofino Agrociencia, BR-14026020 Ribeirao Preto, SP, BrazilSao Paulo State Univ, Med Sch, Dept Neurol Psychol & Psychiat, BR-18618687 Botucatu, SP, BrazilSao Paulo State Univ, Sch Sci, Dept Phys, Av Eng Luiz Edmundo Carrijo Coube 14-01, BR-17033360 Bauru, SP, BrazilSao Paulo State Univ, Med Sch, Dept Neurol Psychol & Psychiat, BR-18618687 Botucatu, SP, BrazilFAPESP: 2017/20032-5FAPESP: 2015/22864-2Nature Publishing GroupUniversidade Estadual Paulista (Unesp)Ourofino AgrocienciaOliveira, Marcela de [UNESP]Ribeiro Gianeti, Thiago MarceloGomes da Rocha, Fernando Coronetti [UNESP]Lisboa-Filho, Paulo Noronha [UNESP]Piacenti-Silva, Marina [UNESP]2020-12-10T20:09:24Z2020-12-10T20:09:24Z2020-08-04info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article8http://dx.doi.org/10.1038/s41598-020-69979-9Scientific Reports. London: Nature Publishing Group, v. 10, n. 1, 8 p., 2020.2045-2322http://hdl.handle.net/11449/19720110.1038/s41598-020-69979-9WOS:000561101700003Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengScientific Reportsinfo:eu-repo/semantics/openAccess2024-04-25T17:39:39Zoai:repositorio.unesp.br:11449/197201Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-25T17:39:39Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS |
title |
A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS |
spellingShingle |
A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS Oliveira, Marcela de [UNESP] |
title_short |
A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS |
title_full |
A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS |
title_fullStr |
A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS |
title_full_unstemmed |
A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS |
title_sort |
A preliminary study of the concentration of metallic elements in the blood of patients with multiple sclerosis as measured by ICP-MS |
author |
Oliveira, Marcela de [UNESP] |
author_facet |
Oliveira, Marcela de [UNESP] Ribeiro Gianeti, Thiago Marcelo Gomes da Rocha, Fernando Coronetti [UNESP] Lisboa-Filho, Paulo Noronha [UNESP] Piacenti-Silva, Marina [UNESP] |
author_role |
author |
author2 |
Ribeiro Gianeti, Thiago Marcelo Gomes da Rocha, Fernando Coronetti [UNESP] Lisboa-Filho, Paulo Noronha [UNESP] Piacenti-Silva, Marina [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Ourofino Agrociencia |
dc.contributor.author.fl_str_mv |
Oliveira, Marcela de [UNESP] Ribeiro Gianeti, Thiago Marcelo Gomes da Rocha, Fernando Coronetti [UNESP] Lisboa-Filho, Paulo Noronha [UNESP] Piacenti-Silva, Marina [UNESP] |
description |
It is estimated that multiple sclerosis (MS) affects 35,000 Brazilians and 2.5 million individuals worldwide. Many studies have suggested a possible role of metallic elements in the etiology of MS, but their concentration in the blood of MS patients is nonetheless little investigated in Brazil. In this work, these elements were studied through Inductively Coupled Plasma Mass Spectrometry (ICP-MS), whose analysis provides a tool to quantify the concentrations of metal elements in the blood samples of individuals with neurodegenerative disorders. This study aimed to compare the concentration of metallic elements in blood samples from patients with MS and healthy individuals. Blood was collected from 30 patients with multiple sclerosis and compared with the control group. Blood samples were digested in closed vessels using a microwave and ICP-MS was used to determine the concentrations of 12 metallic elements (Ba, Be, Ca, Co, Cr, Cu, Fe, Mg, Mo, Ni, Pb and Zn). In MS patients, we observed a reduction in the concentrations of beryllium, copper, chromium, cobalt, nickel, magnesium and iron. The mean concentration of lead in blood was significantly elevated in the MS group. However, no difference was observed in the concentrations of Mo, Ba, Ca and Zn in blood samples from MS patients and the control group. According to our data, there is a possible role for the concentrations of 8 of the 12 evaluated metallic elements in multiple sclerosis. Abnormalities in transition metals levels in biological matrices have been reported in several neurological diseases. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-10T20:09:24Z 2020-12-10T20:09:24Z 2020-08-04 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1038/s41598-020-69979-9 Scientific Reports. London: Nature Publishing Group, v. 10, n. 1, 8 p., 2020. 2045-2322 http://hdl.handle.net/11449/197201 10.1038/s41598-020-69979-9 WOS:000561101700003 |
url |
http://dx.doi.org/10.1038/s41598-020-69979-9 http://hdl.handle.net/11449/197201 |
identifier_str_mv |
Scientific Reports. London: Nature Publishing Group, v. 10, n. 1, 8 p., 2020. 2045-2322 10.1038/s41598-020-69979-9 WOS:000561101700003 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Scientific Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
8 |
dc.publisher.none.fl_str_mv |
Nature Publishing Group |
publisher.none.fl_str_mv |
Nature Publishing Group |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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