Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1155/2018/6428630 http://hdl.handle.net/11449/175891 |
Resumo: | Background. Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lIPid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats. Method. 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n=8): CTRL: Control rats; CTRL+NAC: Control rats treated with NAC; DM: Diabetic rats; DM+NAC: Diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, IP; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lIPid profile, and AI. Results. NAC decreased (p<0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p<0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (p<0.01) lIPid profile and AI in diabetic rats (DM+NAC) when compared to DM. Conclusion. NAC improves lIPid profile and decreases AI in STZ-induced diabetic rats. |
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Repositório Institucional da UNESP |
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spelling |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic ratsBackground. Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lIPid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats. Method. 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n=8): CTRL: Control rats; CTRL+NAC: Control rats treated with NAC; DM: Diabetic rats; DM+NAC: Diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, IP; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lIPid profile, and AI. Results. NAC decreased (p<0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p<0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (p<0.01) lIPid profile and AI in diabetic rats (DM+NAC) when compared to DM. Conclusion. NAC improves lIPid profile and decreases AI in STZ-induced diabetic rats.Department of Chemistry and Biochemistry Institute of Biosciences of Botucatu Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/nDepartment of Chemistry and Biochemistry Institute of Biosciences of Botucatu Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/nUniversidade Estadual Paulista (Unesp)Kaga, Anderson Kiyoshi [UNESP]Barbanera, Pedro Octavio [UNESP]Carmo, Nágilla Orleanne Lima Do [UNESP]Rosa, Lucas Rodolfo De Oliveira [UNESP]Fernandes, Ana Angélica Henrique [UNESP]2018-12-11T17:18:01Z2018-12-11T17:18:01Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1155/2018/6428630International Journal of Vascular Medicine, v. 2018.2090-28322090-2824http://hdl.handle.net/11449/17589110.1155/2018/64286302-s2.0-850421099552-s2.0-85042109955.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Vascular Medicine0,7820,782info:eu-repo/semantics/openAccess2024-01-24T06:28:46Zoai:repositorio.unesp.br:11449/175891Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-01-24T06:28:46Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats |
title |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats |
spellingShingle |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats Kaga, Anderson Kiyoshi [UNESP] |
title_short |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats |
title_full |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats |
title_fullStr |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats |
title_full_unstemmed |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats |
title_sort |
Effect of N-Acetylcysteine on dyslipidemia and carbohydrate metabolism in STZ-induced diabetic rats |
author |
Kaga, Anderson Kiyoshi [UNESP] |
author_facet |
Kaga, Anderson Kiyoshi [UNESP] Barbanera, Pedro Octavio [UNESP] Carmo, Nágilla Orleanne Lima Do [UNESP] Rosa, Lucas Rodolfo De Oliveira [UNESP] Fernandes, Ana Angélica Henrique [UNESP] |
author_role |
author |
author2 |
Barbanera, Pedro Octavio [UNESP] Carmo, Nágilla Orleanne Lima Do [UNESP] Rosa, Lucas Rodolfo De Oliveira [UNESP] Fernandes, Ana Angélica Henrique [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Kaga, Anderson Kiyoshi [UNESP] Barbanera, Pedro Octavio [UNESP] Carmo, Nágilla Orleanne Lima Do [UNESP] Rosa, Lucas Rodolfo De Oliveira [UNESP] Fernandes, Ana Angélica Henrique [UNESP] |
description |
Background. Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lIPid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats. Method. 32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups (n=8): CTRL: Control rats; CTRL+NAC: Control rats treated with NAC; DM: Diabetic rats; DM+NAC: Diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, IP; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water ad libitum. After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lIPid profile, and AI. Results. NAC decreased (p<0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved (p<0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased (p<0.01) lIPid profile and AI in diabetic rats (DM+NAC) when compared to DM. Conclusion. NAC improves lIPid profile and decreases AI in STZ-induced diabetic rats. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:18:01Z 2018-12-11T17:18:01Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1155/2018/6428630 International Journal of Vascular Medicine, v. 2018. 2090-2832 2090-2824 http://hdl.handle.net/11449/175891 10.1155/2018/6428630 2-s2.0-85042109955 2-s2.0-85042109955.pdf |
url |
http://dx.doi.org/10.1155/2018/6428630 http://hdl.handle.net/11449/175891 |
identifier_str_mv |
International Journal of Vascular Medicine, v. 2018. 2090-2832 2090-2824 10.1155/2018/6428630 2-s2.0-85042109955 2-s2.0-85042109955.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Vascular Medicine 0,782 0,782 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1799965710503378944 |