Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

Detalhes bibliográficos
Autor(a) principal: Martins, Murillo L. [UNESP]
Data de Publicação: 2015
Outros Autores: Orecchini, Andrea, Aguilera, Luis, Eckert, Juergen, Embs, Jan, Matic, Aleksander, Saeki, Margarida Juri [UNESP], Bordallo, Heloisa N., Frick, B., Koza, M. M., Boehm, M., Mutka, H.
Tipo de documento: Artigo de conferência
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.epj-conferences.org/articles/epjconf/abs/2015/02/epjconf-Qens-Wins2014_02011/epjconf-Qens-Wins2014_02011.html
http://hdl.handle.net/11449/128654
Resumo: The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
id UNSP_090cc82cfcef26e14ca103213cf9579e
oai_identifier_str oai:repositorio.unesp.br:11449/128654
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopyThe anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.Univ Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, DenmarkUniv Estadual Paulista, Inst Biociencias, BR-18618970 Botucatu, SP, BrazilInst Max Von Laue Paul Langevin, F-38042 Grenoble, FranceUniv Perugia, Dipartimento Fis, I-06123 Perugia, ItalyChalmers, Dept Appl Phys, S-41296 Gothenburg, SwedenUniv S Florida, Dept Chem, Tampa, FL 33620 USAPaul Scherrer Inst, Neutron Scattering Lab, CH-5232 Villigen, SwitzerlandUniv Estadual Paulista, Inst Biociencias, Departamento de Química e Bioquímica, BR-18618970 Botucatu, SP, BrazilE D P SciencesUniv CopenhagenUniversidade Estadual Paulista (Unesp)Inst Max Von Laue Paul LangevinUniv PerugiaChalmersUniv S FloridaPaul Scherrer InstMartins, Murillo L. [UNESP]Orecchini, AndreaAguilera, LuisEckert, JuergenEmbs, JanMatic, AleksanderSaeki, Margarida Juri [UNESP]Bordallo, Heloisa N.Frick, B.Koza, M. M.Boehm, M.Mutka, H.2015-10-21T13:11:56Z2015-10-21T13:11:56Z2015-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObject1-5application/pdfhttp://www.epj-conferences.org/articles/epjconf/abs/2015/02/epjconf-Qens-Wins2014_02011/epjconf-Qens-Wins2014_02011.htmlQens/wins 2014 - 11th International Conference On Quasielastic Neutron Scattering And 6th International Workshop On Inelastic Neutron Spectrometers. Cedex A: E D P Sciences, v. 83, 5 p., 2015.2100-014Xhttp://hdl.handle.net/11449/12865410.1051/epjconf/20158302011WOS:000351844900013WOS000351844900013.pdf1802982806436894Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengQens/wins 2014 - 11th International Conference On Quasielastic Neutron Scattering And 6th International Workshop On Inelastic Neutron Spectrometersinfo:eu-repo/semantics/openAccess2023-09-30T06:01:00Zoai:repositorio.unesp.br:11449/128654Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:32:10.219451Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
title Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
spellingShingle Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
Martins, Murillo L. [UNESP]
title_short Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
title_full Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
title_fullStr Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
title_full_unstemmed Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
title_sort Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy
author Martins, Murillo L. [UNESP]
author_facet Martins, Murillo L. [UNESP]
Orecchini, Andrea
Aguilera, Luis
Eckert, Juergen
Embs, Jan
Matic, Aleksander
Saeki, Margarida Juri [UNESP]
Bordallo, Heloisa N.
Frick, B.
Koza, M. M.
Boehm, M.
Mutka, H.
author_role author
author2 Orecchini, Andrea
Aguilera, Luis
Eckert, Juergen
Embs, Jan
Matic, Aleksander
Saeki, Margarida Juri [UNESP]
Bordallo, Heloisa N.
Frick, B.
Koza, M. M.
Boehm, M.
Mutka, H.
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Univ Copenhagen
Universidade Estadual Paulista (Unesp)
Inst Max Von Laue Paul Langevin
Univ Perugia
Chalmers
Univ S Florida
Paul Scherrer Inst
dc.contributor.author.fl_str_mv Martins, Murillo L. [UNESP]
Orecchini, Andrea
Aguilera, Luis
Eckert, Juergen
Embs, Jan
Matic, Aleksander
Saeki, Margarida Juri [UNESP]
Bordallo, Heloisa N.
Frick, B.
Koza, M. M.
Boehm, M.
Mutka, H.
description The anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.
publishDate 2015
dc.date.none.fl_str_mv 2015-10-21T13:11:56Z
2015-10-21T13:11:56Z
2015-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/conferenceObject
format conferenceObject
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.epj-conferences.org/articles/epjconf/abs/2015/02/epjconf-Qens-Wins2014_02011/epjconf-Qens-Wins2014_02011.html
Qens/wins 2014 - 11th International Conference On Quasielastic Neutron Scattering And 6th International Workshop On Inelastic Neutron Spectrometers. Cedex A: E D P Sciences, v. 83, 5 p., 2015.
2100-014X
http://hdl.handle.net/11449/128654
10.1051/epjconf/20158302011
WOS:000351844900013
WOS000351844900013.pdf
1802982806436894
url http://www.epj-conferences.org/articles/epjconf/abs/2015/02/epjconf-Qens-Wins2014_02011/epjconf-Qens-Wins2014_02011.html
http://hdl.handle.net/11449/128654
identifier_str_mv Qens/wins 2014 - 11th International Conference On Quasielastic Neutron Scattering And 6th International Workshop On Inelastic Neutron Spectrometers. Cedex A: E D P Sciences, v. 83, 5 p., 2015.
2100-014X
10.1051/epjconf/20158302011
WOS:000351844900013
WOS000351844900013.pdf
1802982806436894
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Qens/wins 2014 - 11th International Conference On Quasielastic Neutron Scattering And 6th International Workshop On Inelastic Neutron Spectrometers
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1-5
application/pdf
dc.publisher.none.fl_str_mv E D P Sciences
publisher.none.fl_str_mv E D P Sciences
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128243286409216

Registros relacionados