Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jff.2020.104105 http://hdl.handle.net/11449/199210 |
Resumo: | This study investigated the effects of babassu and coconut oil supplementation in breast cancer patients. This randomized clinical trial included 60 patients divided into three groups: untreated control group (CG), babassu oil group (BG), and coconut oil group (COG). Fatigue, quality of life, depression, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and salivary IgA were analysed before and after 12 weeks of supplementation. Babassu supplementation decreased fatigue and improved quality of life but did not affect depression scores. Babassu also decreased TNF-α and IL-6 levels and increased IgA in saliva compared to the COG and CG. In conclusion, babassu oil supplementation reduced fatigue and improved the quality of life of breast cancer patients, and these outcomes are probably related to the immunomodulatory effects of babassu oil in reducing proinflammatory cytokines and increasing IgA antibody production. These findings indicate that babassu oil may be useful as a supplement to reduce cancer-related fatigue. |
id |
UNSP_09762461ead73ea14b4f0a577230ac0a |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/199210 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trialBabassu oilBreast cancerDietary supplementsFatigueImmunomodulationThis study investigated the effects of babassu and coconut oil supplementation in breast cancer patients. This randomized clinical trial included 60 patients divided into three groups: untreated control group (CG), babassu oil group (BG), and coconut oil group (COG). Fatigue, quality of life, depression, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and salivary IgA were analysed before and after 12 weeks of supplementation. Babassu supplementation decreased fatigue and improved quality of life but did not affect depression scores. Babassu also decreased TNF-α and IL-6 levels and increased IgA in saliva compared to the COG and CG. In conclusion, babassu oil supplementation reduced fatigue and improved the quality of life of breast cancer patients, and these outcomes are probably related to the immunomodulatory effects of babassu oil in reducing proinflammatory cytokines and increasing IgA antibody production. These findings indicate that babassu oil may be useful as a supplement to reduce cancer-related fatigue.Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do MaranhãoLaboratory of Immunophysiology Universidade Federal do Maranhão – Centro de Ciências Biológicas e da SaúdePain and Palliative Care – Centro de Ciências Biológicas e da SaúdeUniversidade Estadual Paulista - UNESPUniversidade Federal do Espírito SantoUniversidade Estadual Paulista - UNESPUniversidade Federal do Maranhão – Centro de Ciências Biológicas e da SaúdePain and Palliative Care – Centro de Ciências Biológicas e da SaúdeUniversidade Estadual Paulista (Unesp)Universidade Federal do Espírito Santo (UFES)Pereira, Paula Tâmara Vieira TeixeiraReis, Andréa Dias [UNESP]Silva, Surama do Carmo SousaSerra, Larissa de Lourdes PadilhaLeite, Richard DiegoSilva, Mayara Cristina PintoLima-Aragão, Mônica Virginia ViegasNascimento, Flavia Raquel FernandesGarcia, João Batista SantosGuerra, Rosane Nassar Meireles2020-12-12T01:33:44Z2020-12-12T01:33:44Z2020-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.jff.2020.104105Journal of Functional Foods, v. 73.1756-4646http://hdl.handle.net/11449/19921010.1016/j.jff.2020.1041052-s2.0-85088978502Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Functional Foodsinfo:eu-repo/semantics/openAccess2021-10-23T04:53:41Zoai:repositorio.unesp.br:11449/199210Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T04:53:41Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial |
title |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial |
spellingShingle |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial Pereira, Paula Tâmara Vieira Teixeira Babassu oil Breast cancer Dietary supplements Fatigue Immunomodulation |
title_short |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial |
title_full |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial |
title_fullStr |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial |
title_full_unstemmed |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial |
title_sort |
Supplementation with babassu oil reduces fatigue and inflammation in breast cancer patients: A pilot randomized clinical trial |
author |
Pereira, Paula Tâmara Vieira Teixeira |
author_facet |
Pereira, Paula Tâmara Vieira Teixeira Reis, Andréa Dias [UNESP] Silva, Surama do Carmo Sousa Serra, Larissa de Lourdes Padilha Leite, Richard Diego Silva, Mayara Cristina Pinto Lima-Aragão, Mônica Virginia Viegas Nascimento, Flavia Raquel Fernandes Garcia, João Batista Santos Guerra, Rosane Nassar Meireles |
author_role |
author |
author2 |
Reis, Andréa Dias [UNESP] Silva, Surama do Carmo Sousa Serra, Larissa de Lourdes Padilha Leite, Richard Diego Silva, Mayara Cristina Pinto Lima-Aragão, Mônica Virginia Viegas Nascimento, Flavia Raquel Fernandes Garcia, João Batista Santos Guerra, Rosane Nassar Meireles |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal do Maranhão – Centro de Ciências Biológicas e da Saúde Pain and Palliative Care – Centro de Ciências Biológicas e da Saúde Universidade Estadual Paulista (Unesp) Universidade Federal do Espírito Santo (UFES) |
dc.contributor.author.fl_str_mv |
Pereira, Paula Tâmara Vieira Teixeira Reis, Andréa Dias [UNESP] Silva, Surama do Carmo Sousa Serra, Larissa de Lourdes Padilha Leite, Richard Diego Silva, Mayara Cristina Pinto Lima-Aragão, Mônica Virginia Viegas Nascimento, Flavia Raquel Fernandes Garcia, João Batista Santos Guerra, Rosane Nassar Meireles |
dc.subject.por.fl_str_mv |
Babassu oil Breast cancer Dietary supplements Fatigue Immunomodulation |
topic |
Babassu oil Breast cancer Dietary supplements Fatigue Immunomodulation |
description |
This study investigated the effects of babassu and coconut oil supplementation in breast cancer patients. This randomized clinical trial included 60 patients divided into three groups: untreated control group (CG), babassu oil group (BG), and coconut oil group (COG). Fatigue, quality of life, depression, tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and salivary IgA were analysed before and after 12 weeks of supplementation. Babassu supplementation decreased fatigue and improved quality of life but did not affect depression scores. Babassu also decreased TNF-α and IL-6 levels and increased IgA in saliva compared to the COG and CG. In conclusion, babassu oil supplementation reduced fatigue and improved the quality of life of breast cancer patients, and these outcomes are probably related to the immunomodulatory effects of babassu oil in reducing proinflammatory cytokines and increasing IgA antibody production. These findings indicate that babassu oil may be useful as a supplement to reduce cancer-related fatigue. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T01:33:44Z 2020-12-12T01:33:44Z 2020-10-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jff.2020.104105 Journal of Functional Foods, v. 73. 1756-4646 http://hdl.handle.net/11449/199210 10.1016/j.jff.2020.104105 2-s2.0-85088978502 |
url |
http://dx.doi.org/10.1016/j.jff.2020.104105 http://hdl.handle.net/11449/199210 |
identifier_str_mv |
Journal of Functional Foods, v. 73. 1756-4646 10.1016/j.jff.2020.104105 2-s2.0-85088978502 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Functional Foods |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965120118390784 |