Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum)
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10695-016-0211-9 http://hdl.handle.net/11449/172602 |
Resumo: | The baroreflex is one of the most important regulators of cardiovascular homeostasis in vertebrates. It begins with the monitoring of arterial pressure by baroreceptors, which constantly provide the central nervous system with afferent information about the status of this variable. Any change in arterial pressure relative to its normal state triggers autonomic responses, which are characterized by an inversely proportional change in heart rate and systemic vascular resistance and which tend to restore pressure normality. Although the baroreceptors have been located in mammals and other terrestrial vertebrates, their location in fish is still not completely clear and remains quite controversial. Thus, the objective of this study was to locate the baroreceptors in a teleost, the Colossoma macropomum. To do so, the occurrence and efficiency of the baroreflex were both analyzed when this mechanism was induced by pressure imbalancements in intact fish (IN), first-gill-denervated fish (G1), and total-gill-denervated fish (G4). The pressure imbalances were initiated through the administration of the α1-adrenergic agonist phenylephrine (100 µg kg−1) and the α1-adrenergic antagonist prazosin (1 mg kg−1). The baroreflex responses were then analyzed using an electrocardiogram that allowed for the measurement of the heart rate, the relationship between pre- and post-pharmacological manipulation heart rates, the time required for maximum chronotropic baroreflex response, and total heart rate variability. The results revealed that the barostatic reflex was attenuated in the G1 group and nonexistent in G4 group, findings which indicate that baroreceptors are exclusively located in the gill arches of C. macropomum. |
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Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum)BaroreceptorBaroreflexGillsTambaquiTeleostThe baroreflex is one of the most important regulators of cardiovascular homeostasis in vertebrates. It begins with the monitoring of arterial pressure by baroreceptors, which constantly provide the central nervous system with afferent information about the status of this variable. Any change in arterial pressure relative to its normal state triggers autonomic responses, which are characterized by an inversely proportional change in heart rate and systemic vascular resistance and which tend to restore pressure normality. Although the baroreceptors have been located in mammals and other terrestrial vertebrates, their location in fish is still not completely clear and remains quite controversial. Thus, the objective of this study was to locate the baroreceptors in a teleost, the Colossoma macropomum. To do so, the occurrence and efficiency of the baroreflex were both analyzed when this mechanism was induced by pressure imbalancements in intact fish (IN), first-gill-denervated fish (G1), and total-gill-denervated fish (G4). The pressure imbalances were initiated through the administration of the α1-adrenergic agonist phenylephrine (100 µg kg−1) and the α1-adrenergic antagonist prazosin (1 mg kg−1). The baroreflex responses were then analyzed using an electrocardiogram that allowed for the measurement of the heart rate, the relationship between pre- and post-pharmacological manipulation heart rates, the time required for maximum chronotropic baroreflex response, and total heart rate variability. The results revealed that the barostatic reflex was attenuated in the G1 group and nonexistent in G4 group, findings which indicate that baroreceptors are exclusively located in the gill arches of C. macropomum.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Department of Physiological Sciences Federal University of São Carlos (UFSCar), Rodovia Washington Luiz, km 235Department of Zoology and Botany São Paulo State University (UNESP), Rua Cristóvão Colombo, 2265National Institute of Science and Technology in Comparative Physiology (INCT – FAPESP/CNPq)Aquaculture Center (CAUNESP) São Paulo State University (UNESP), Rodovia Prof. Paulo Donato Castellane, n/nDepartment of Zoology and Botany São Paulo State University (UNESP), Rua Cristóvão Colombo, 2265Aquaculture Center (CAUNESP) São Paulo State University (UNESP), Rodovia Prof. Paulo Donato Castellane, n/nUniversidade Federal de São Carlos (UFSCar)Universidade Estadual Paulista (Unesp)National Institute of Science and Technology in Comparative Physiology (INCT – FAPESP/CNPq)Armelin, Vinicius AraújoBraga, Victor Hugo da Silva [UNESP]Teixeira, Mariana Teodoro [UNESP]Rantin, Francisco TadeuFlorindo, Luiz Henrique [UNESP]Kalinin, Ana Lúcia2018-12-11T17:01:18Z2018-12-11T17:01:18Z2016-08-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1213-1224application/pdfhttp://dx.doi.org/10.1007/s10695-016-0211-9Fish Physiology and Biochemistry, v. 42, n. 4, p. 1213-1224, 2016.1573-51680920-1742http://hdl.handle.net/11449/17260210.1007/s10695-016-0211-92-s2.0-849593312862-s2.0-84959331286.pdf2797832406818407Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengFish Physiology and Biochemistry0,6900,690info:eu-repo/semantics/openAccess2024-04-09T15:36:52Zoai:repositorio.unesp.br:11449/172602Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:14:42.393293Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum) |
title |
Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum) |
spellingShingle |
Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum) Armelin, Vinicius Araújo Baroreceptor Baroreflex Gills Tambaqui Teleost |
title_short |
Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum) |
title_full |
Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum) |
title_fullStr |
Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum) |
title_full_unstemmed |
Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum) |
title_sort |
Gill denervation eliminates the barostatic reflex in a neotropical teleost, the tambaqui (Colossoma macropomum) |
author |
Armelin, Vinicius Araújo |
author_facet |
Armelin, Vinicius Araújo Braga, Victor Hugo da Silva [UNESP] Teixeira, Mariana Teodoro [UNESP] Rantin, Francisco Tadeu Florindo, Luiz Henrique [UNESP] Kalinin, Ana Lúcia |
author_role |
author |
author2 |
Braga, Victor Hugo da Silva [UNESP] Teixeira, Mariana Teodoro [UNESP] Rantin, Francisco Tadeu Florindo, Luiz Henrique [UNESP] Kalinin, Ana Lúcia |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Carlos (UFSCar) Universidade Estadual Paulista (Unesp) National Institute of Science and Technology in Comparative Physiology (INCT – FAPESP/CNPq) |
dc.contributor.author.fl_str_mv |
Armelin, Vinicius Araújo Braga, Victor Hugo da Silva [UNESP] Teixeira, Mariana Teodoro [UNESP] Rantin, Francisco Tadeu Florindo, Luiz Henrique [UNESP] Kalinin, Ana Lúcia |
dc.subject.por.fl_str_mv |
Baroreceptor Baroreflex Gills Tambaqui Teleost |
topic |
Baroreceptor Baroreflex Gills Tambaqui Teleost |
description |
The baroreflex is one of the most important regulators of cardiovascular homeostasis in vertebrates. It begins with the monitoring of arterial pressure by baroreceptors, which constantly provide the central nervous system with afferent information about the status of this variable. Any change in arterial pressure relative to its normal state triggers autonomic responses, which are characterized by an inversely proportional change in heart rate and systemic vascular resistance and which tend to restore pressure normality. Although the baroreceptors have been located in mammals and other terrestrial vertebrates, their location in fish is still not completely clear and remains quite controversial. Thus, the objective of this study was to locate the baroreceptors in a teleost, the Colossoma macropomum. To do so, the occurrence and efficiency of the baroreflex were both analyzed when this mechanism was induced by pressure imbalancements in intact fish (IN), first-gill-denervated fish (G1), and total-gill-denervated fish (G4). The pressure imbalances were initiated through the administration of the α1-adrenergic agonist phenylephrine (100 µg kg−1) and the α1-adrenergic antagonist prazosin (1 mg kg−1). The baroreflex responses were then analyzed using an electrocardiogram that allowed for the measurement of the heart rate, the relationship between pre- and post-pharmacological manipulation heart rates, the time required for maximum chronotropic baroreflex response, and total heart rate variability. The results revealed that the barostatic reflex was attenuated in the G1 group and nonexistent in G4 group, findings which indicate that baroreceptors are exclusively located in the gill arches of C. macropomum. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-08-01 2018-12-11T17:01:18Z 2018-12-11T17:01:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10695-016-0211-9 Fish Physiology and Biochemistry, v. 42, n. 4, p. 1213-1224, 2016. 1573-5168 0920-1742 http://hdl.handle.net/11449/172602 10.1007/s10695-016-0211-9 2-s2.0-84959331286 2-s2.0-84959331286.pdf 2797832406818407 |
url |
http://dx.doi.org/10.1007/s10695-016-0211-9 http://hdl.handle.net/11449/172602 |
identifier_str_mv |
Fish Physiology and Biochemistry, v. 42, n. 4, p. 1213-1224, 2016. 1573-5168 0920-1742 10.1007/s10695-016-0211-9 2-s2.0-84959331286 2-s2.0-84959331286.pdf 2797832406818407 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Fish Physiology and Biochemistry 0,690 0,690 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1213-1224 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808129177884295168 |