Cardiac autonomic modulation impairments in advanced breast cancer patients
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00392-018-1264-9 http://hdl.handle.net/11449/231419 |
Resumo: | Aim: To compare cardiac autonomic modulation in early- versus advanced-stage breast cancer patients before any type of cancer treatment and investigate associated factors. Methods and results: This cross-sectional study included women (30–69 years old) with primary diagnosis of breast cancer and women with benign breast tumors. We evaluated cardiac modulation by heart rate variability and assessed factors of anxiety, depression, physical activity, and other relevant medical variables. Patients were divided into three groups based on TNM staging of cancer severity: early-stage cancer (n = 42), advanced-stage cancer (n = 37), or benign breast tumors to serve as a control (n = 37). We analyzed heart rate variability in time and frequency domains. The advanced-stage cancer group had lower vagal modulation than early-stage and benign groups; also, the advance-stage group had lower overall heart rate variability when compared to benign conditions. Heart rate variability was influenced by age, menopausal status, and BMI. Conclusions: Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging. |
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Cardiac autonomic modulation impairments in advanced breast cancer patientsAutonomic nervous systemBreast tumorCardiologyTNM classificationAim: To compare cardiac autonomic modulation in early- versus advanced-stage breast cancer patients before any type of cancer treatment and investigate associated factors. Methods and results: This cross-sectional study included women (30–69 years old) with primary diagnosis of breast cancer and women with benign breast tumors. We evaluated cardiac modulation by heart rate variability and assessed factors of anxiety, depression, physical activity, and other relevant medical variables. Patients were divided into three groups based on TNM staging of cancer severity: early-stage cancer (n = 42), advanced-stage cancer (n = 37), or benign breast tumors to serve as a control (n = 37). We analyzed heart rate variability in time and frequency domains. The advanced-stage cancer group had lower vagal modulation than early-stage and benign groups; also, the advance-stage group had lower overall heart rate variability when compared to benign conditions. Heart rate variability was influenced by age, menopausal status, and BMI. Conclusions: Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging.Departamento de Medicina Disciplina de Cardiologia Hospital São Paulo Escola Paulista de Medicina Universidade Federal de São Paulo, 715 Napoleão de Barros StDepartamento de Fisioterapia Faculdade de Ciência e Tecnologia Universidade do Estado de São Paulo, 305 Roberto Símonsen StFaculdade de Medicina do ABC Laboratório de Epidemiologia e Análise de Dados, 2000 Lauro Gomes AvDepartment of Physiology and Institute of Molecular Cardiology School of Medicine University of Louisville, Baxter Biomedical Research Building II, 590 S Preston StInstituto do Câncer Doutor Arnaldo Vieira de Carvalho, 66 Largo do AroucheDepartamento de Ginecologia Hospital São Paulo Escola Paulista de Medicina Universidade Federal de São PauloCentro de Referência da Saúde da Mulher Hospital Pérola Byington, 683 Brigadeiro Luís Antônio AveDepartamento de Medicina Disciplina de Clínica Médica Hospital São Paulo Escola Paulista de Medicina Universidade Federal de São PauloFree University of Brussels (VUB), Boulevard de la Plaine 2Universidade Federal de São Paulo (UNIFESP)Universidade do Estado de São PauloLaboratório de Epidemiologia e Análise de DadosUniversity of LouisvilleInstituto do Câncer Doutor Arnaldo Vieira de CarvalhoHospital Pérola ByingtonFree University of Brussels (VUB)Arab, ClaudiaVanderlei, Luiz Carlos Marquesda Silva Paiva, LaércioFulghum, Kyle LeviFristachi, Carlos EliasNazario, Afonso Celso PintoElias, SimoneGebrim, Luiz HenriqueFerreira Filho, CelsoGidron, YoriFerreira, Celso2022-04-29T08:45:22Z2022-04-29T08:45:22Z2018-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article924-936http://dx.doi.org/10.1007/s00392-018-1264-9Clinical Research in Cardiology, v. 107, n. 10, p. 924-936, 2018.1861-06921861-0684http://hdl.handle.net/11449/23141910.1007/s00392-018-1264-92-s2.0-85051228118Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengClinical Research in Cardiologyinfo:eu-repo/semantics/openAccess2024-08-16T14:06:43Zoai:repositorio.unesp.br:11449/231419Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-16T14:06:43Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Cardiac autonomic modulation impairments in advanced breast cancer patients |
title |
Cardiac autonomic modulation impairments in advanced breast cancer patients |
spellingShingle |
Cardiac autonomic modulation impairments in advanced breast cancer patients Arab, Claudia Autonomic nervous system Breast tumor Cardiology TNM classification |
title_short |
Cardiac autonomic modulation impairments in advanced breast cancer patients |
title_full |
Cardiac autonomic modulation impairments in advanced breast cancer patients |
title_fullStr |
Cardiac autonomic modulation impairments in advanced breast cancer patients |
title_full_unstemmed |
Cardiac autonomic modulation impairments in advanced breast cancer patients |
title_sort |
Cardiac autonomic modulation impairments in advanced breast cancer patients |
author |
Arab, Claudia |
author_facet |
Arab, Claudia Vanderlei, Luiz Carlos Marques da Silva Paiva, Laércio Fulghum, Kyle Levi Fristachi, Carlos Elias Nazario, Afonso Celso Pinto Elias, Simone Gebrim, Luiz Henrique Ferreira Filho, Celso Gidron, Yori Ferreira, Celso |
author_role |
author |
author2 |
Vanderlei, Luiz Carlos Marques da Silva Paiva, Laércio Fulghum, Kyle Levi Fristachi, Carlos Elias Nazario, Afonso Celso Pinto Elias, Simone Gebrim, Luiz Henrique Ferreira Filho, Celso Gidron, Yori Ferreira, Celso |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Universidade do Estado de São Paulo Laboratório de Epidemiologia e Análise de Dados University of Louisville Instituto do Câncer Doutor Arnaldo Vieira de Carvalho Hospital Pérola Byington Free University of Brussels (VUB) |
dc.contributor.author.fl_str_mv |
Arab, Claudia Vanderlei, Luiz Carlos Marques da Silva Paiva, Laércio Fulghum, Kyle Levi Fristachi, Carlos Elias Nazario, Afonso Celso Pinto Elias, Simone Gebrim, Luiz Henrique Ferreira Filho, Celso Gidron, Yori Ferreira, Celso |
dc.subject.por.fl_str_mv |
Autonomic nervous system Breast tumor Cardiology TNM classification |
topic |
Autonomic nervous system Breast tumor Cardiology TNM classification |
description |
Aim: To compare cardiac autonomic modulation in early- versus advanced-stage breast cancer patients before any type of cancer treatment and investigate associated factors. Methods and results: This cross-sectional study included women (30–69 years old) with primary diagnosis of breast cancer and women with benign breast tumors. We evaluated cardiac modulation by heart rate variability and assessed factors of anxiety, depression, physical activity, and other relevant medical variables. Patients were divided into three groups based on TNM staging of cancer severity: early-stage cancer (n = 42), advanced-stage cancer (n = 37), or benign breast tumors to serve as a control (n = 37). We analyzed heart rate variability in time and frequency domains. The advanced-stage cancer group had lower vagal modulation than early-stage and benign groups; also, the advance-stage group had lower overall heart rate variability when compared to benign conditions. Heart rate variability was influenced by age, menopausal status, and BMI. Conclusions: Heart rate variability seems to be a promising, non-invasive tool for early diagnosis of autonomic dysfunction in breast cancer and detection of cardiovascular impairments at cancer diagnosis. Cardiac autonomic modulation is inversely associated with breast cancer staging. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10-01 2022-04-29T08:45:22Z 2022-04-29T08:45:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00392-018-1264-9 Clinical Research in Cardiology, v. 107, n. 10, p. 924-936, 2018. 1861-0692 1861-0684 http://hdl.handle.net/11449/231419 10.1007/s00392-018-1264-9 2-s2.0-85051228118 |
url |
http://dx.doi.org/10.1007/s00392-018-1264-9 http://hdl.handle.net/11449/231419 |
identifier_str_mv |
Clinical Research in Cardiology, v. 107, n. 10, p. 924-936, 2018. 1861-0692 1861-0684 10.1007/s00392-018-1264-9 2-s2.0-85051228118 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Clinical Research in Cardiology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
924-936 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128128010158080 |