Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration

Detalhes bibliográficos
Autor(a) principal: Zanatelli, Marianna
Data de Publicação: 2021
Outros Autores: Colleta, Simone Jacovaci [UNESP], Guerra, Luiz Henrique Alves [UNESP], Santos, Fernanda Cristina Alcântara, Góes, Rejane Maira [UNESP], Vilamaior, Patricia Simone Leite [UNESP], Taboga, Sebastião Roberto [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/s12958-021-00777-2
http://hdl.handle.net/11449/229073
Resumo: Background: The male and female prostates are controlled by steroid hormones, suffering important morphological and physiological changes after castration. Prolactin is involved in the regulation of the male prostate, having already been identified in the tissue, acting through its receptor PRLR. In the Mongolian gerbil, in addition to the male prostate, the female prostate is also well developed and active in its secretion processes. The aim of the present study was to evaluate the effects of exposure to exogenous prolactin in the prostate of both intact and castrated male and female gerbils in order to establish if prolactin administration can sustain prostate cell activity in conditions of sexual hormone deprivation. Methods: The morphological analyses were performed by biometric analysis, lesion histological analysis and morphometric-stereological aspects. In addition, immune-cytochemical tests were performed for prolactin and its receptor, as well as for the receptors of androgen and oestrogen and serum prolactin dosage. All data were submitted to ANOVA or Kruskal-Wallis tests for comparison between groups. P < 0.05 was considered to be statistically significant. Results: The results showed a strong influence of prolactin on the morphology of the prostate, with the development of important epithelial alterations, after only 3 days of administration, and an expressive epithelial cell discard process after 30 days of administration. Prolactin acts in synergy with testosterone in males and mainly with oestrogens in females, establishing different steroid hormonal receptor immunoreactivity according to sex. It was also demonstrated that prolactin can assist in the recovery from some atrophic effects caused in the gland after castration, without causing additional tissue damage. Conclusions: The prolactin and its receptor are involved in the maintenance of the homeostasis of male and female gerbils, and also cause distinct histological alterations after exogenous exposure for 3 and 30 days. The effects of prolactin are related to its joint action on androgens and oestrogens and it can also assist in the recovery from the atrophic effects of castration.
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spelling Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castrationCastrationFemale prostateGerbilProlactinProlactin receptorProstateBackground: The male and female prostates are controlled by steroid hormones, suffering important morphological and physiological changes after castration. Prolactin is involved in the regulation of the male prostate, having already been identified in the tissue, acting through its receptor PRLR. In the Mongolian gerbil, in addition to the male prostate, the female prostate is also well developed and active in its secretion processes. The aim of the present study was to evaluate the effects of exposure to exogenous prolactin in the prostate of both intact and castrated male and female gerbils in order to establish if prolactin administration can sustain prostate cell activity in conditions of sexual hormone deprivation. Methods: The morphological analyses were performed by biometric analysis, lesion histological analysis and morphometric-stereological aspects. In addition, immune-cytochemical tests were performed for prolactin and its receptor, as well as for the receptors of androgen and oestrogen and serum prolactin dosage. All data were submitted to ANOVA or Kruskal-Wallis tests for comparison between groups. P < 0.05 was considered to be statistically significant. Results: The results showed a strong influence of prolactin on the morphology of the prostate, with the development of important epithelial alterations, after only 3 days of administration, and an expressive epithelial cell discard process after 30 days of administration. Prolactin acts in synergy with testosterone in males and mainly with oestrogens in females, establishing different steroid hormonal receptor immunoreactivity according to sex. It was also demonstrated that prolactin can assist in the recovery from some atrophic effects caused in the gland after castration, without causing additional tissue damage. Conclusions: The prolactin and its receptor are involved in the maintenance of the homeostasis of male and female gerbils, and also cause distinct histological alterations after exogenous exposure for 3 and 30 days. The effects of prolactin are related to its joint action on androgens and oestrogens and it can also assist in the recovery from the atrophic effects of castration.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Department of Structural and Functional Biology Institute of Biology State University of Campinas – UNICAMPLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University – UNESP/IBILCE, Rua Cristóvão Colombo, 2265, Jardim NazarethDepartment of Morphology Federal University of Goiás -UFGLaboratory of Microscopy and Microanalysis Department of Biology São Paulo State University – UNESP/IBILCE, Rua Cristóvão Colombo, 2265, Jardim NazarethFAPESP: 2012/00695-6CNPq: 301596/2011-5CNPq: 442630/2014-0Universidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (UNESP)Universidade Federal de Goiás (UFG)Zanatelli, MariannaColleta, Simone Jacovaci [UNESP]Guerra, Luiz Henrique Alves [UNESP]Santos, Fernanda Cristina AlcântaraGóes, Rejane Maira [UNESP]Vilamaior, Patricia Simone Leite [UNESP]Taboga, Sebastião Roberto [UNESP]2022-04-29T08:30:15Z2022-04-29T08:30:15Z2021-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1186/s12958-021-00777-2Reproductive Biology and Endocrinology, v. 19, n. 1, 2021.1477-7827http://hdl.handle.net/11449/22907310.1186/s12958-021-00777-22-s2.0-85109056782Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproductive Biology and Endocrinologyinfo:eu-repo/semantics/openAccess2024-04-11T19:33:50Zoai:repositorio.unesp.br:11449/229073Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:09:24.556287Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration
title Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration
spellingShingle Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration
Zanatelli, Marianna
Castration
Female prostate
Gerbil
Prolactin
Prolactin receptor
Prostate
title_short Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration
title_full Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration
title_fullStr Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration
title_full_unstemmed Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration
title_sort Prolactin promotes a partial recovery from the atrophy of both male and female gerbil prostates caused by castration
author Zanatelli, Marianna
author_facet Zanatelli, Marianna
Colleta, Simone Jacovaci [UNESP]
Guerra, Luiz Henrique Alves [UNESP]
Santos, Fernanda Cristina Alcântara
Góes, Rejane Maira [UNESP]
Vilamaior, Patricia Simone Leite [UNESP]
Taboga, Sebastião Roberto [UNESP]
author_role author
author2 Colleta, Simone Jacovaci [UNESP]
Guerra, Luiz Henrique Alves [UNESP]
Santos, Fernanda Cristina Alcântara
Góes, Rejane Maira [UNESP]
Vilamaior, Patricia Simone Leite [UNESP]
Taboga, Sebastião Roberto [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Estadual Paulista (UNESP)
Universidade Federal de Goiás (UFG)
dc.contributor.author.fl_str_mv Zanatelli, Marianna
Colleta, Simone Jacovaci [UNESP]
Guerra, Luiz Henrique Alves [UNESP]
Santos, Fernanda Cristina Alcântara
Góes, Rejane Maira [UNESP]
Vilamaior, Patricia Simone Leite [UNESP]
Taboga, Sebastião Roberto [UNESP]
dc.subject.por.fl_str_mv Castration
Female prostate
Gerbil
Prolactin
Prolactin receptor
Prostate
topic Castration
Female prostate
Gerbil
Prolactin
Prolactin receptor
Prostate
description Background: The male and female prostates are controlled by steroid hormones, suffering important morphological and physiological changes after castration. Prolactin is involved in the regulation of the male prostate, having already been identified in the tissue, acting through its receptor PRLR. In the Mongolian gerbil, in addition to the male prostate, the female prostate is also well developed and active in its secretion processes. The aim of the present study was to evaluate the effects of exposure to exogenous prolactin in the prostate of both intact and castrated male and female gerbils in order to establish if prolactin administration can sustain prostate cell activity in conditions of sexual hormone deprivation. Methods: The morphological analyses were performed by biometric analysis, lesion histological analysis and morphometric-stereological aspects. In addition, immune-cytochemical tests were performed for prolactin and its receptor, as well as for the receptors of androgen and oestrogen and serum prolactin dosage. All data were submitted to ANOVA or Kruskal-Wallis tests for comparison between groups. P < 0.05 was considered to be statistically significant. Results: The results showed a strong influence of prolactin on the morphology of the prostate, with the development of important epithelial alterations, after only 3 days of administration, and an expressive epithelial cell discard process after 30 days of administration. Prolactin acts in synergy with testosterone in males and mainly with oestrogens in females, establishing different steroid hormonal receptor immunoreactivity according to sex. It was also demonstrated that prolactin can assist in the recovery from some atrophic effects caused in the gland after castration, without causing additional tissue damage. Conclusions: The prolactin and its receptor are involved in the maintenance of the homeostasis of male and female gerbils, and also cause distinct histological alterations after exogenous exposure for 3 and 30 days. The effects of prolactin are related to its joint action on androgens and oestrogens and it can also assist in the recovery from the atrophic effects of castration.
publishDate 2021
dc.date.none.fl_str_mv 2021-12-01
2022-04-29T08:30:15Z
2022-04-29T08:30:15Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/s12958-021-00777-2
Reproductive Biology and Endocrinology, v. 19, n. 1, 2021.
1477-7827
http://hdl.handle.net/11449/229073
10.1186/s12958-021-00777-2
2-s2.0-85109056782
url http://dx.doi.org/10.1186/s12958-021-00777-2
http://hdl.handle.net/11449/229073
identifier_str_mv Reproductive Biology and Endocrinology, v. 19, n. 1, 2021.
1477-7827
10.1186/s12958-021-00777-2
2-s2.0-85109056782
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Reproductive Biology and Endocrinology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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