O emprego de hormônio luteinizante recombinante associado ao hormônio folículo-estimulante recombinante nos protocolos de estimulação ovariana com antagonista do GnRH

• Autor(a) principal: Baruffi, Ricardo L.R.
• Data de Publicação: 2006
• Outros Autores: Mauri, Ana L. [UNESP], Petersen, Cláudia G. [UNESP], Felipe, Valéria, Martins, Anice M.C. [UNESP], Cornicelli, João, Cavagna, Mario, Oliveira, João B.A., Franco Junior, Jose Gonçalves [UNESP]
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: https://www.academia.edu/3490307/ICSI-gestational_Carrier_Association_as_a_Strategy_for_Treatment_of_Mayer-_Rokitansky-Kuster-Hauser_Syndrome_Patients_Case_Report_and_Literature_Review; http://hdl.handle.net/11449/69156
• topic: GnRH antagonist; Ovarian stimulation; Recombinant FSH; Recombinant LH; cetrorelix; chorionic gonadotropin; estradiol; ethinylestradiol; ethinylestradiol plus gestodene; gonadorelin antagonist; levonorgestrel; oral contraceptive agent; recombinant follitropin; recombinant luteinizing hormone; clinical trial; combination chemotherapy; data base; drug dose regimen; drug efficacy; drug mechanism; estradiol blood level; hormone substitution; human; low drug dose; meta analysis; monotherapy; oocyte; ovary function; pregnancy rate; spontaneous abortion; systematic review

The purpose of this investigation was to verify the efficacy of recombinant LH supplementation for controlled ovarian stimulation in GnRH-antagonist protocol for assisted reproductive technologies cycles. Search strategies included on-line surveys of databases from 1990 to 2006. In this review and meta-analysis, the observed advantages for the LH supplementation protocol were a higher serum estradiol levels on the day of hCG administration and a higher number of mature oocytes. However, there were no differences observed in the total amount of r-FSH administered, days of stimulation, number of oocyte retrieved, the clinical pregnancy rate per oocyte retrieval, the implantation rate and miscarriage rate. This result demonstrates that the association of r-LH with r-FSH may prevent any decrease in estradiol after antagonist administration and a significant higher number of mature oocytes was obtained. Nevertheless, additional randomized controlled trials are needed confirm these observations.