Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.jcpa.2016.01.002 http://hdl.handle.net/11449/158833 |
Resumo: | Ephrin A3 (EphA3), a member of the ephrin receptor tyrosine kinase family, is involved in a variety of functions in normal cells, especially during embryonic development, and alterations in its expression profile have been observed in several human cancers. However, there are no reports of the expression of EphA3 in normal, hyperplastic or neoplastic canine prostate tissue or in other types of canine tumours. Six normal, 15 hyper plastic and 21 neoplastic canine prostates were examined immunohistochemically with a polyclonal antibody specific for human EphA3. The percentage of positive cells in all prostatic carcinomas was increased, with a mean of 89.28 +/- 5.18% compared with normal (9.17 +/- 6.72%) and hyperplastic prostates (20.00 +/- 8.28%). EphA3 expression was not correlated with the histological subtypes of prostate cancer or with the Gleason score. The increase in EphA3 expression in canine prostatic carcinomas suggests the involvement of this receptor in prostatic carcinogenesis and its potential use as a target for new therapeutic strategies. (C) 2016 Elsevier Ltd. All rights reserved. |
id |
UNSP_0a6c83a2a0dd23ce76cdc422e9ceb60d |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/158833 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Overexpression of Ephrin A3 Receptor in Canine Prostatic CarcinomacancerdogEphA3prostateEphrin A3 (EphA3), a member of the ephrin receptor tyrosine kinase family, is involved in a variety of functions in normal cells, especially during embryonic development, and alterations in its expression profile have been observed in several human cancers. However, there are no reports of the expression of EphA3 in normal, hyperplastic or neoplastic canine prostate tissue or in other types of canine tumours. Six normal, 15 hyper plastic and 21 neoplastic canine prostates were examined immunohistochemically with a polyclonal antibody specific for human EphA3. The percentage of positive cells in all prostatic carcinomas was increased, with a mean of 89.28 +/- 5.18% compared with normal (9.17 +/- 6.72%) and hyperplastic prostates (20.00 +/- 8.28%). EphA3 expression was not correlated with the histological subtypes of prostate cancer or with the Gleason score. The increase in EphA3 expression in canine prostatic carcinomas suggests the involvement of this receptor in prostatic carcinogenesis and its potential use as a target for new therapeutic strategies. (C) 2016 Elsevier Ltd. All rights reserved.John and Kibble Trust grantDr William Peter Richards Bequest for Research in Veterinary PathologyUniv Queensland, Sch Vet Sci, Gatton Campus, Gatton, Qld, AustraliaUniv Estadual Paulista, Sch Vet Med & Anim Sci, Sao Paulo, BrazilUniv Estadual Paulista, Sch Vet Med & Anim Sci, Sao Paulo, BrazilElsevier B.V.Univ QueenslandUniversidade Estadual Paulista (Unesp)Hood, G.Laufer-Amorim, R. [UNESP]Fonseca-Alves, C. E. [UNESP]Palmieri, C.2018-11-26T15:29:22Z2018-11-26T15:29:22Z2016-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article180-185application/pdfhttp://dx.doi.org/10.1016/j.jcpa.2016.01.002Journal Of Comparative Pathology. Oxford: Elsevier Sci Ltd, v. 154, n. 2-3, p. 180-185, 2016.0021-9975http://hdl.handle.net/11449/15883310.1016/j.jcpa.2016.01.002WOS:000374920300008WOS000374920300008.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal Of Comparative Pathology0,594info:eu-repo/semantics/openAccess2023-11-21T06:14:54Zoai:repositorio.unesp.br:11449/158833Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:21:17.126964Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma |
title |
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma |
spellingShingle |
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma Hood, G. cancer dog EphA3 prostate |
title_short |
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma |
title_full |
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma |
title_fullStr |
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma |
title_full_unstemmed |
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma |
title_sort |
Overexpression of Ephrin A3 Receptor in Canine Prostatic Carcinoma |
author |
Hood, G. |
author_facet |
Hood, G. Laufer-Amorim, R. [UNESP] Fonseca-Alves, C. E. [UNESP] Palmieri, C. |
author_role |
author |
author2 |
Laufer-Amorim, R. [UNESP] Fonseca-Alves, C. E. [UNESP] Palmieri, C. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Univ Queensland Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Hood, G. Laufer-Amorim, R. [UNESP] Fonseca-Alves, C. E. [UNESP] Palmieri, C. |
dc.subject.por.fl_str_mv |
cancer dog EphA3 prostate |
topic |
cancer dog EphA3 prostate |
description |
Ephrin A3 (EphA3), a member of the ephrin receptor tyrosine kinase family, is involved in a variety of functions in normal cells, especially during embryonic development, and alterations in its expression profile have been observed in several human cancers. However, there are no reports of the expression of EphA3 in normal, hyperplastic or neoplastic canine prostate tissue or in other types of canine tumours. Six normal, 15 hyper plastic and 21 neoplastic canine prostates were examined immunohistochemically with a polyclonal antibody specific for human EphA3. The percentage of positive cells in all prostatic carcinomas was increased, with a mean of 89.28 +/- 5.18% compared with normal (9.17 +/- 6.72%) and hyperplastic prostates (20.00 +/- 8.28%). EphA3 expression was not correlated with the histological subtypes of prostate cancer or with the Gleason score. The increase in EphA3 expression in canine prostatic carcinomas suggests the involvement of this receptor in prostatic carcinogenesis and its potential use as a target for new therapeutic strategies. (C) 2016 Elsevier Ltd. All rights reserved. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-02-01 2018-11-26T15:29:22Z 2018-11-26T15:29:22Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.jcpa.2016.01.002 Journal Of Comparative Pathology. Oxford: Elsevier Sci Ltd, v. 154, n. 2-3, p. 180-185, 2016. 0021-9975 http://hdl.handle.net/11449/158833 10.1016/j.jcpa.2016.01.002 WOS:000374920300008 WOS000374920300008.pdf |
url |
http://dx.doi.org/10.1016/j.jcpa.2016.01.002 http://hdl.handle.net/11449/158833 |
identifier_str_mv |
Journal Of Comparative Pathology. Oxford: Elsevier Sci Ltd, v. 154, n. 2-3, p. 180-185, 2016. 0021-9975 10.1016/j.jcpa.2016.01.002 WOS:000374920300008 WOS000374920300008.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal Of Comparative Pathology 0,594 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
180-185 application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier B.V. |
publisher.none.fl_str_mv |
Elsevier B.V. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128924336521216 |