Exercise Training Attenuates Cirrhotic Cardiomyopathy

Detalhes bibliográficos
Autor(a) principal: de Souza, Sérgio Luiz Borges [UNESP]
Data de Publicação: 2020
Outros Autores: Mota, Gustavo Augusto Ferreira [UNESP], Gregolin, Cristina Schmitt, do Nascimento, Milena, Luvizotto, Renata Azevedo Melo, Bazan, Silmeia Garcia Zanati [UNESP], Sugizaki, Mário Mateus, Barbisan, Luis Fernando [UNESP], Cicogna, Antonio Carlos [UNESP], do Nascimento, André Ferreira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s12265-020-09997-0
http://hdl.handle.net/11449/200270
Resumo: Cirrhotic cardiomyopathy is a condition where liver cirrhosis is associated with cardiac dysfunction. Triggers and blockers of cirrhotic cardiomyopathy are poorly understood, which might compromise the prognosis of chronic liver disease patients. We tested whether exercise training would reduce liver damage induced by thioacetamide and prevent liver cirrhosis-associated cardiomyopathy. Wistar rats were divided into three groups: control, thioacetamide (TAA), or TAA plus exercise. Thioacetamide increased liver weight and serum alanine aminotransferase and aspartate aminotransferase levels. Also, TAA treatment was involved with hepatic nodule formation, fibrotic septa, inflammatory infiltration, and hepatocyte necrosis. The exercise group presented with a reduction in liver injury status. We found that liver injury was associated with disordered cardiac hypertrophy as well as diastolic and systolic dysfunction. Exercise training attenuated cirrhosis-associated cardiac remodeling and diastolic dysfunction and prevented systolic impairment. These results provided insights that exercise training can mitigate cirrhotic cardiomyopathy phenotype. [Figure not available: see fulltext.].
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spelling Exercise Training Attenuates Cirrhotic CardiomyopathyCardiac dysfunctionCirrhotic cardiomyopathyExercise trainingLiver cirrhosisThioacetamideCirrhotic cardiomyopathy is a condition where liver cirrhosis is associated with cardiac dysfunction. Triggers and blockers of cirrhotic cardiomyopathy are poorly understood, which might compromise the prognosis of chronic liver disease patients. We tested whether exercise training would reduce liver damage induced by thioacetamide and prevent liver cirrhosis-associated cardiomyopathy. Wistar rats were divided into three groups: control, thioacetamide (TAA), or TAA plus exercise. Thioacetamide increased liver weight and serum alanine aminotransferase and aspartate aminotransferase levels. Also, TAA treatment was involved with hepatic nodule formation, fibrotic septa, inflammatory infiltration, and hepatocyte necrosis. The exercise group presented with a reduction in liver injury status. We found that liver injury was associated with disordered cardiac hypertrophy as well as diastolic and systolic dysfunction. Exercise training attenuated cirrhosis-associated cardiac remodeling and diastolic dysfunction and prevented systolic impairment. These results provided insights that exercise training can mitigate cirrhotic cardiomyopathy phenotype. [Figure not available: see fulltext.].Department of Internal Medicine Botucatu School of Medicine São Paulo State University (UNESP), BotucatuInstitute of Health Sciences Federal University of Mato Grosso (UFMT), Avenida Alexandre Ferronato, n°1200, Setor IndustrialDepartment of Morphology Institute of Biosciences Sao Paulo State University (UNESP)Department of Internal Medicine Botucatu School of Medicine São Paulo State University (UNESP), BotucatuDepartment of Morphology Institute of Biosciences Sao Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Federal University of Mato Grosso (UFMT)de Souza, Sérgio Luiz Borges [UNESP]Mota, Gustavo Augusto Ferreira [UNESP]Gregolin, Cristina Schmittdo Nascimento, MilenaLuvizotto, Renata Azevedo MeloBazan, Silmeia Garcia Zanati [UNESP]Sugizaki, Mário MateusBarbisan, Luis Fernando [UNESP]Cicogna, Antonio Carlos [UNESP]do Nascimento, André Ferreira2020-12-12T02:02:09Z2020-12-12T02:02:09Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1007/s12265-020-09997-0Journal of Cardiovascular Translational Research.1937-53951937-5387http://hdl.handle.net/11449/20027010.1007/s12265-020-09997-02-s2.0-85083191816Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Cardiovascular Translational Researchinfo:eu-repo/semantics/openAccess2024-08-14T17:21:51Zoai:repositorio.unesp.br:11449/200270Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:21:51Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Exercise Training Attenuates Cirrhotic Cardiomyopathy
title Exercise Training Attenuates Cirrhotic Cardiomyopathy
spellingShingle Exercise Training Attenuates Cirrhotic Cardiomyopathy
de Souza, Sérgio Luiz Borges [UNESP]
Cardiac dysfunction
Cirrhotic cardiomyopathy
Exercise training
Liver cirrhosis
Thioacetamide
title_short Exercise Training Attenuates Cirrhotic Cardiomyopathy
title_full Exercise Training Attenuates Cirrhotic Cardiomyopathy
title_fullStr Exercise Training Attenuates Cirrhotic Cardiomyopathy
title_full_unstemmed Exercise Training Attenuates Cirrhotic Cardiomyopathy
title_sort Exercise Training Attenuates Cirrhotic Cardiomyopathy
author de Souza, Sérgio Luiz Borges [UNESP]
author_facet de Souza, Sérgio Luiz Borges [UNESP]
Mota, Gustavo Augusto Ferreira [UNESP]
Gregolin, Cristina Schmitt
do Nascimento, Milena
Luvizotto, Renata Azevedo Melo
Bazan, Silmeia Garcia Zanati [UNESP]
Sugizaki, Mário Mateus
Barbisan, Luis Fernando [UNESP]
Cicogna, Antonio Carlos [UNESP]
do Nascimento, André Ferreira
author_role author
author2 Mota, Gustavo Augusto Ferreira [UNESP]
Gregolin, Cristina Schmitt
do Nascimento, Milena
Luvizotto, Renata Azevedo Melo
Bazan, Silmeia Garcia Zanati [UNESP]
Sugizaki, Mário Mateus
Barbisan, Luis Fernando [UNESP]
Cicogna, Antonio Carlos [UNESP]
do Nascimento, André Ferreira
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Federal University of Mato Grosso (UFMT)
dc.contributor.author.fl_str_mv de Souza, Sérgio Luiz Borges [UNESP]
Mota, Gustavo Augusto Ferreira [UNESP]
Gregolin, Cristina Schmitt
do Nascimento, Milena
Luvizotto, Renata Azevedo Melo
Bazan, Silmeia Garcia Zanati [UNESP]
Sugizaki, Mário Mateus
Barbisan, Luis Fernando [UNESP]
Cicogna, Antonio Carlos [UNESP]
do Nascimento, André Ferreira
dc.subject.por.fl_str_mv Cardiac dysfunction
Cirrhotic cardiomyopathy
Exercise training
Liver cirrhosis
Thioacetamide
topic Cardiac dysfunction
Cirrhotic cardiomyopathy
Exercise training
Liver cirrhosis
Thioacetamide
description Cirrhotic cardiomyopathy is a condition where liver cirrhosis is associated with cardiac dysfunction. Triggers and blockers of cirrhotic cardiomyopathy are poorly understood, which might compromise the prognosis of chronic liver disease patients. We tested whether exercise training would reduce liver damage induced by thioacetamide and prevent liver cirrhosis-associated cardiomyopathy. Wistar rats were divided into three groups: control, thioacetamide (TAA), or TAA plus exercise. Thioacetamide increased liver weight and serum alanine aminotransferase and aspartate aminotransferase levels. Also, TAA treatment was involved with hepatic nodule formation, fibrotic septa, inflammatory infiltration, and hepatocyte necrosis. The exercise group presented with a reduction in liver injury status. We found that liver injury was associated with disordered cardiac hypertrophy as well as diastolic and systolic dysfunction. Exercise training attenuated cirrhosis-associated cardiac remodeling and diastolic dysfunction and prevented systolic impairment. These results provided insights that exercise training can mitigate cirrhotic cardiomyopathy phenotype. [Figure not available: see fulltext.].
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:02:09Z
2020-12-12T02:02:09Z
2020-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s12265-020-09997-0
Journal of Cardiovascular Translational Research.
1937-5395
1937-5387
http://hdl.handle.net/11449/200270
10.1007/s12265-020-09997-0
2-s2.0-85083191816
url http://dx.doi.org/10.1007/s12265-020-09997-0
http://hdl.handle.net/11449/200270
identifier_str_mv Journal of Cardiovascular Translational Research.
1937-5395
1937-5387
10.1007/s12265-020-09997-0
2-s2.0-85083191816
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Cardiovascular Translational Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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