Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2298/PAC2104374H http://hdl.handle.net/11449/234118 |
Resumo: | In this study, we investigated the structural, microstructural, magnetic and cytotoxic properties of encapsulated ZnFe2O4nanoparticles. The nanoparticles were synthesized using the microwave-assisted hydrothermal method and their surfaces were silanized and later encapsulated with poly-2-hydroxyethyl methacrylate (PHEMA). Due to the compatibility of Zn2+ions with a human body, ZnFe2O4nanoparticles are preferable among all kinds of ferrites for biomedical applications. Quantitative phase analysis obtained by the Rietveld refinement reveals the formation of a single-phase spinel cubic structure. Magnetic hysteresis loops measured at 2 and 300K reveal a remanent magnetization of 4.427 emu/g and 1.002 emu/g, respectively. Such behaviour was ascribed to change in the inversion degree of the spinel structure. The experimental g-factor (g = 1.897) obtained using electron paramagnetic resonance analysis can be attributed to the microwave heating, which induces more surface-active oxygen species. In addition, we demonstrated that the encapsulated ZnFe2O4nanoparticles showed an absence of cytotoxicity at concentrations of 1.0, 10 and 20 μg/ml against human embryonic kidney (HEK) cells since no significant changes in cell morphology were observed. Hence, our results indicate the possibility to explore the use of ZnFe2O4nanoparticles encapsulated with PHEMA for biomedical applications, such as cancer therapies. |
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Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal methodElectronic paramagnetic resonanceMagnetic propertiesMicrowave processingNanopowdersIn this study, we investigated the structural, microstructural, magnetic and cytotoxic properties of encapsulated ZnFe2O4nanoparticles. The nanoparticles were synthesized using the microwave-assisted hydrothermal method and their surfaces were silanized and later encapsulated with poly-2-hydroxyethyl methacrylate (PHEMA). Due to the compatibility of Zn2+ions with a human body, ZnFe2O4nanoparticles are preferable among all kinds of ferrites for biomedical applications. Quantitative phase analysis obtained by the Rietveld refinement reveals the formation of a single-phase spinel cubic structure. Magnetic hysteresis loops measured at 2 and 300K reveal a remanent magnetization of 4.427 emu/g and 1.002 emu/g, respectively. Such behaviour was ascribed to change in the inversion degree of the spinel structure. The experimental g-factor (g = 1.897) obtained using electron paramagnetic resonance analysis can be attributed to the microwave heating, which induces more surface-active oxygen species. In addition, we demonstrated that the encapsulated ZnFe2O4nanoparticles showed an absence of cytotoxicity at concentrations of 1.0, 10 and 20 μg/ml against human embryonic kidney (HEK) cells since no significant changes in cell morphology were observed. Hence, our results indicate the possibility to explore the use of ZnFe2O4nanoparticles encapsulated with PHEMA for biomedical applications, such as cancer therapies.São Paulo State University (UNESP) School of Engineering, Av. Dr. Ariberto Pereira da Cunha 333, GuaratinguetáFederal University of Itajubá (UNIFEI) Institute of Physics and Chemistry, Av. BPS 1303, ItajubáSão Paulo State University (UNESP) School of Engineering, Av. Dr. Ariberto Pereira da Cunha 333, GuaratinguetáUniversidade Estadual Paulista (UNESP)Institute of Physics and ChemistryHangai, Bruno [UNESP]Acero, Gonny [UNESP]Ortega, Pedro Paulo [UNESP]Garcia, Filiberto G.Simões, Alexandre Z. [UNESP]2022-05-01T13:41:31Z2022-05-01T13:41:31Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article374-384http://dx.doi.org/10.2298/PAC2104374HProcessing and Application of Ceramics, v. 15, n. 4, p. 374-384, 2021.2406-10341820-6131http://hdl.handle.net/11449/23411810.2298/PAC2104374H2-s2.0-85124275069Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengProcessing and Application of Ceramicsinfo:eu-repo/semantics/openAccess2024-07-02T15:03:33Zoai:repositorio.unesp.br:11449/234118Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T14:41:00.815152Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method |
title |
Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method |
spellingShingle |
Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method Hangai, Bruno [UNESP] Electronic paramagnetic resonance Magnetic properties Microwave processing Nanopowders |
title_short |
Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method |
title_full |
Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method |
title_fullStr |
Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method |
title_full_unstemmed |
Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method |
title_sort |
Bioactivity evaluation of nanosized ZnFe2O4fabricated by hydrothermal method |
author |
Hangai, Bruno [UNESP] |
author_facet |
Hangai, Bruno [UNESP] Acero, Gonny [UNESP] Ortega, Pedro Paulo [UNESP] Garcia, Filiberto G. Simões, Alexandre Z. [UNESP] |
author_role |
author |
author2 |
Acero, Gonny [UNESP] Ortega, Pedro Paulo [UNESP] Garcia, Filiberto G. Simões, Alexandre Z. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Institute of Physics and Chemistry |
dc.contributor.author.fl_str_mv |
Hangai, Bruno [UNESP] Acero, Gonny [UNESP] Ortega, Pedro Paulo [UNESP] Garcia, Filiberto G. Simões, Alexandre Z. [UNESP] |
dc.subject.por.fl_str_mv |
Electronic paramagnetic resonance Magnetic properties Microwave processing Nanopowders |
topic |
Electronic paramagnetic resonance Magnetic properties Microwave processing Nanopowders |
description |
In this study, we investigated the structural, microstructural, magnetic and cytotoxic properties of encapsulated ZnFe2O4nanoparticles. The nanoparticles were synthesized using the microwave-assisted hydrothermal method and their surfaces were silanized and later encapsulated with poly-2-hydroxyethyl methacrylate (PHEMA). Due to the compatibility of Zn2+ions with a human body, ZnFe2O4nanoparticles are preferable among all kinds of ferrites for biomedical applications. Quantitative phase analysis obtained by the Rietveld refinement reveals the formation of a single-phase spinel cubic structure. Magnetic hysteresis loops measured at 2 and 300K reveal a remanent magnetization of 4.427 emu/g and 1.002 emu/g, respectively. Such behaviour was ascribed to change in the inversion degree of the spinel structure. The experimental g-factor (g = 1.897) obtained using electron paramagnetic resonance analysis can be attributed to the microwave heating, which induces more surface-active oxygen species. In addition, we demonstrated that the encapsulated ZnFe2O4nanoparticles showed an absence of cytotoxicity at concentrations of 1.0, 10 and 20 μg/ml against human embryonic kidney (HEK) cells since no significant changes in cell morphology were observed. Hence, our results indicate the possibility to explore the use of ZnFe2O4nanoparticles encapsulated with PHEMA for biomedical applications, such as cancer therapies. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-01-01 2022-05-01T13:41:31Z 2022-05-01T13:41:31Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2298/PAC2104374H Processing and Application of Ceramics, v. 15, n. 4, p. 374-384, 2021. 2406-1034 1820-6131 http://hdl.handle.net/11449/234118 10.2298/PAC2104374H 2-s2.0-85124275069 |
url |
http://dx.doi.org/10.2298/PAC2104374H http://hdl.handle.net/11449/234118 |
identifier_str_mv |
Processing and Application of Ceramics, v. 15, n. 4, p. 374-384, 2021. 2406-1034 1820-6131 10.2298/PAC2104374H 2-s2.0-85124275069 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Processing and Application of Ceramics |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
374-384 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128399789522944 |