Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas

Detalhes bibliográficos
Autor(a) principal: Santos, Jean Leandrodos [UNESP]
Data de Publicação: 2009
Outros Autores: Ribeiro, Y. A. [UNESP], Salgado, Hérida Regina Nunes [UNESP], Chin, Chung Man [UNESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/612
http://hdl.handle.net/11449/70999
Resumo: Ketoconazole is a synthetic broad-spectrum oral and topical antifungal drug derived from imidazole, effective in the treatment of superficial mycoses and systemic infections. In this study we have tested several methods to analyze ketoconazole in various pharmaceutical products containing this drug, employing techniques such as UV and IR spectrophotometry and thermal analysis. The results showed that UV spectrophotometry is a fast, practical and economical method and indicated that other methods, such as IR spectrophotometry and thermal analysis, could be good alternative methods for ketoconazole analysis in certain pharmaceutical forms.
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spelling Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticasStudy of analytical methodology for ketoconazole determination in pharmaceutical preparationAnalytical methodsAntifungalKetoconazoleSpectrophotometric analysisThermal analysisketoconazoleanalytic methoddrug determinationdrug dosage forminfrared spectrophotometrythermal analysisultraviolet spectrophotometryKetoconazole is a synthetic broad-spectrum oral and topical antifungal drug derived from imidazole, effective in the treatment of superficial mycoses and systemic infections. In this study we have tested several methods to analyze ketoconazole in various pharmaceutical products containing this drug, employing techniques such as UV and IR spectrophotometry and thermal analysis. The results showed that UV spectrophotometry is a fast, practical and economical method and indicated that other methods, such as IR spectrophotometry and thermal analysis, could be good alternative methods for ketoconazole analysis in certain pharmaceutical forms.Departamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jau Km1, Araraquara - CEP: 14801-902Departamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, Rodovia Araraquara/Jau Km1, Araraquara - CEP: 14801-902Universidade Estadual Paulista (Unesp)Santos, Jean Leandrodos [UNESP]Ribeiro, Y. A. [UNESP]Salgado, Hérida Regina Nunes [UNESP]Chin, Chung Man [UNESP]2014-05-27T11:23:54Z2014-05-27T11:23:54Z2009-05-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article161-165application/pdfhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/612Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 30, n. 2, p. 161-165, 2009.1808-4532http://hdl.handle.net/11449/709992-s2.0-786498745662-s2.0-78649874566.pdf97343336079754130000-0003-4141-0455Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista de Ciências Farmacêuticas Básica e Aplicada0,131info:eu-repo/semantics/openAccess2024-06-24T13:46:11Zoai:repositorio.unesp.br:11449/70999Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:46:38.044511Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
Study of analytical methodology for ketoconazole determination in pharmaceutical preparation
title Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
spellingShingle Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
Santos, Jean Leandrodos [UNESP]
Analytical methods
Antifungal
Ketoconazole
Spectrophotometric analysis
Thermal analysis
ketoconazole
analytic method
drug determination
drug dosage form
infrared spectrophotometry
thermal analysis
ultraviolet spectrophotometry
title_short Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
title_full Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
title_fullStr Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
title_full_unstemmed Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
title_sort Estudo de metodologia analítica para a determinação do cetoconazol em formulações farmacêuticas
author Santos, Jean Leandrodos [UNESP]
author_facet Santos, Jean Leandrodos [UNESP]
Ribeiro, Y. A. [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
Chin, Chung Man [UNESP]
author_role author
author2 Ribeiro, Y. A. [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
Chin, Chung Man [UNESP]
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Santos, Jean Leandrodos [UNESP]
Ribeiro, Y. A. [UNESP]
Salgado, Hérida Regina Nunes [UNESP]
Chin, Chung Man [UNESP]
dc.subject.por.fl_str_mv Analytical methods
Antifungal
Ketoconazole
Spectrophotometric analysis
Thermal analysis
ketoconazole
analytic method
drug determination
drug dosage form
infrared spectrophotometry
thermal analysis
ultraviolet spectrophotometry
topic Analytical methods
Antifungal
Ketoconazole
Spectrophotometric analysis
Thermal analysis
ketoconazole
analytic method
drug determination
drug dosage form
infrared spectrophotometry
thermal analysis
ultraviolet spectrophotometry
description Ketoconazole is a synthetic broad-spectrum oral and topical antifungal drug derived from imidazole, effective in the treatment of superficial mycoses and systemic infections. In this study we have tested several methods to analyze ketoconazole in various pharmaceutical products containing this drug, employing techniques such as UV and IR spectrophotometry and thermal analysis. The results showed that UV spectrophotometry is a fast, practical and economical method and indicated that other methods, such as IR spectrophotometry and thermal analysis, could be good alternative methods for ketoconazole analysis in certain pharmaceutical forms.
publishDate 2009
dc.date.none.fl_str_mv 2009-05-01
2014-05-27T11:23:54Z
2014-05-27T11:23:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/612
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 30, n. 2, p. 161-165, 2009.
1808-4532
http://hdl.handle.net/11449/70999
2-s2.0-78649874566
2-s2.0-78649874566.pdf
9734333607975413
0000-0003-4141-0455
url http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/612
http://hdl.handle.net/11449/70999
identifier_str_mv Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 30, n. 2, p. 161-165, 2009.
1808-4532
2-s2.0-78649874566
2-s2.0-78649874566.pdf
9734333607975413
0000-0003-4141-0455
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista de Ciências Farmacêuticas Básica e Aplicada
0,131
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 161-165
application/pdf
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808129247010619392

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