A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates
Autor(a) principal: | |
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Data de Publicação: | 1986 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/02681218680000711 http://hdl.handle.net/11449/231340 |
Resumo: | We carried out a comparative study of the histopathology (lung, liver, spleen, kidney and adrenals) and the anti-P. brasiliensis humoral (immunodiffusion test) and cellular (footpad test) immune response of mice intravenously inoculated with yeast forms of three P. brasiliensis isolates (Pb 18, Pb 192, Pb 265). Pb 265 (avirulent strain) did not evoke specific lesions or antibody production; the levels of cellular immunity were significantly lower than those of the two other isolates. Lung granulomas induced by strain Pb 18 were richer in fungi and neutrophils and poorer in mononuclear cells when compared to those induced by strain Pb 192. Extrapulmonary lesions were more frequent in mice infected with strain Pb 18. Strains Pb 18 and Pb 192 raised similar humoral and cellular anti-P. brasiliensis responses. Cell wall analysis did not suggest striking differences among the strains. Slightly higher levels of the water soluble fraction 3 (which contains the immunogenic galactomannan and protein) were detected in strain Pb 265. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
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A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolatesWe carried out a comparative study of the histopathology (lung, liver, spleen, kidney and adrenals) and the anti-P. brasiliensis humoral (immunodiffusion test) and cellular (footpad test) immune response of mice intravenously inoculated with yeast forms of three P. brasiliensis isolates (Pb 18, Pb 192, Pb 265). Pb 265 (avirulent strain) did not evoke specific lesions or antibody production; the levels of cellular immunity were significantly lower than those of the two other isolates. Lung granulomas induced by strain Pb 18 were richer in fungi and neutrophils and poorer in mononuclear cells when compared to those induced by strain Pb 192. Extrapulmonary lesions were more frequent in mice infected with strain Pb 18. Strains Pb 18 and Pb 192 raised similar humoral and cellular anti-P. brasiliensis responses. Cell wall analysis did not suggest striking differences among the strains. Slightly higher levels of the water soluble fraction 3 (which contains the immunogenic galactomannan and protein) were detected in strain Pb 265. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.Departamento de Patologia Faculdade de Medicina, Botucatu, 18610, São PauloCentro de Microbiologia y Biologia Celular del Instituto Venezolano de Investigaciones Cientificas, CaracasFaculdade de MedicinaCentro de Microbiologia y Biologia Celular del Instituto Venezolano de Investigaciones CientificasZacharias, DarwinUeda, AneteMoscardi-Bacchi, MauraFranco, MarcelloSan-Blas, Gioconda2022-04-29T08:44:52Z2022-04-29T08:44:52Z1986-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article445-454http://dx.doi.org/10.1080/02681218680000711Medical Mycology, v. 24, n. 6, p. 445-454, 1986.1369-3786http://hdl.handle.net/11449/23134010.1080/026812186800007112-s2.0-84907128203Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical Mycologyinfo:eu-repo/semantics/openAccess2024-09-03T13:15:16Zoai:repositorio.unesp.br:11449/231340Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-03T13:15:16Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates |
title |
A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates |
spellingShingle |
A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates Zacharias, Darwin |
title_short |
A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates |
title_full |
A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates |
title_fullStr |
A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates |
title_full_unstemmed |
A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates |
title_sort |
A comparative histopathological, immunological, and biochemical study of experimental intravenous paracoccidioidomycosis induced in mice by three paracoccidioides brasiliensis isolates |
author |
Zacharias, Darwin |
author_facet |
Zacharias, Darwin Ueda, Anete Moscardi-Bacchi, Maura Franco, Marcello San-Blas, Gioconda |
author_role |
author |
author2 |
Ueda, Anete Moscardi-Bacchi, Maura Franco, Marcello San-Blas, Gioconda |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina Centro de Microbiologia y Biologia Celular del Instituto Venezolano de Investigaciones Cientificas |
dc.contributor.author.fl_str_mv |
Zacharias, Darwin Ueda, Anete Moscardi-Bacchi, Maura Franco, Marcello San-Blas, Gioconda |
description |
We carried out a comparative study of the histopathology (lung, liver, spleen, kidney and adrenals) and the anti-P. brasiliensis humoral (immunodiffusion test) and cellular (footpad test) immune response of mice intravenously inoculated with yeast forms of three P. brasiliensis isolates (Pb 18, Pb 192, Pb 265). Pb 265 (avirulent strain) did not evoke specific lesions or antibody production; the levels of cellular immunity were significantly lower than those of the two other isolates. Lung granulomas induced by strain Pb 18 were richer in fungi and neutrophils and poorer in mononuclear cells when compared to those induced by strain Pb 192. Extrapulmonary lesions were more frequent in mice infected with strain Pb 18. Strains Pb 18 and Pb 192 raised similar humoral and cellular anti-P. brasiliensis responses. Cell wall analysis did not suggest striking differences among the strains. Slightly higher levels of the water soluble fraction 3 (which contains the immunogenic galactomannan and protein) were detected in strain Pb 265. © 1986 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted. |
publishDate |
1986 |
dc.date.none.fl_str_mv |
1986-01-01 2022-04-29T08:44:52Z 2022-04-29T08:44:52Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/02681218680000711 Medical Mycology, v. 24, n. 6, p. 445-454, 1986. 1369-3786 http://hdl.handle.net/11449/231340 10.1080/02681218680000711 2-s2.0-84907128203 |
url |
http://dx.doi.org/10.1080/02681218680000711 http://hdl.handle.net/11449/231340 |
identifier_str_mv |
Medical Mycology, v. 24, n. 6, p. 445-454, 1986. 1369-3786 10.1080/02681218680000711 2-s2.0-84907128203 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Medical Mycology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
445-454 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
repositoriounesp@unesp.br |
_version_ |
1810021390061928448 |