Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/j.tcam.2021.100588 http://hdl.handle.net/11449/233792 |
Resumo: | Chronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD. |
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Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogscaninekidneymagnesium homeostasisnephrologyChronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD.Veterinary Teaching Hospital/Animal Science Graduate Program Franca University (UNIFRAN)Graduate Program in Veterinary Science (PPGCV)/College of Veterinary Medicine (FAMEV) Federal University of Uberlândia (UFU)Veterinary Medicine Graduate Program/School of Veterinary Medicine and Animal Science (FMVZ) Paulista State University (UNESP)Department of Veterinary Clinic and Surgery Paulista State University (UNESP)Veterinary Medicine Graduate Program/School of Veterinary Medicine and Animal Science (FMVZ) Paulista State University (UNESP)Department of Veterinary Clinic and Surgery Paulista State University (UNESP)Franca University (UNIFRAN)Universidade Federal de Uberlândia (UFU)Universidade Estadual Paulista (UNESP)de Lima, Charles SilvaFerreira, Karina Rodrigues GomesBorin-Crivellenti, SofiaMaia, Suellen Rodrigues [UNESP]Santana, Aureo Evangelista [UNESP]Crivellenti, Leandro Zuccolotto2022-05-01T10:18:58Z2022-05-01T10:18:58Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tcam.2021.100588Topics in Companion Animal Medicine, v. 46.1938-9736http://hdl.handle.net/11449/23379210.1016/j.tcam.2021.1005882-s2.0-85118944087Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTopics in Companion Animal Medicineinfo:eu-repo/semantics/openAccess2024-06-06T14:10:47Zoai:repositorio.unesp.br:11449/233792Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:11:15.292492Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs |
title |
Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs |
spellingShingle |
Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs de Lima, Charles Silva canine kidney magnesium homeostasis nephrology |
title_short |
Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs |
title_full |
Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs |
title_fullStr |
Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs |
title_full_unstemmed |
Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs |
title_sort |
Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs |
author |
de Lima, Charles Silva |
author_facet |
de Lima, Charles Silva Ferreira, Karina Rodrigues Gomes Borin-Crivellenti, Sofia Maia, Suellen Rodrigues [UNESP] Santana, Aureo Evangelista [UNESP] Crivellenti, Leandro Zuccolotto |
author_role |
author |
author2 |
Ferreira, Karina Rodrigues Gomes Borin-Crivellenti, Sofia Maia, Suellen Rodrigues [UNESP] Santana, Aureo Evangelista [UNESP] Crivellenti, Leandro Zuccolotto |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Franca University (UNIFRAN) Universidade Federal de Uberlândia (UFU) Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
de Lima, Charles Silva Ferreira, Karina Rodrigues Gomes Borin-Crivellenti, Sofia Maia, Suellen Rodrigues [UNESP] Santana, Aureo Evangelista [UNESP] Crivellenti, Leandro Zuccolotto |
dc.subject.por.fl_str_mv |
canine kidney magnesium homeostasis nephrology |
topic |
canine kidney magnesium homeostasis nephrology |
description |
Chronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-05-01T10:18:58Z 2022-05-01T10:18:58Z 2022-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.tcam.2021.100588 Topics in Companion Animal Medicine, v. 46. 1938-9736 http://hdl.handle.net/11449/233792 10.1016/j.tcam.2021.100588 2-s2.0-85118944087 |
url |
http://dx.doi.org/10.1016/j.tcam.2021.100588 http://hdl.handle.net/11449/233792 |
identifier_str_mv |
Topics in Companion Animal Medicine, v. 46. 1938-9736 10.1016/j.tcam.2021.100588 2-s2.0-85118944087 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Topics in Companion Animal Medicine |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129295532425216 |