Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs

Detalhes bibliográficos
Autor(a) principal: de Lima, Charles Silva
Data de Publicação: 2022
Outros Autores: Ferreira, Karina Rodrigues Gomes, Borin-Crivellenti, Sofia, Maia, Suellen Rodrigues [UNESP], Santana, Aureo Evangelista [UNESP], Crivellenti, Leandro Zuccolotto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.tcam.2021.100588
http://hdl.handle.net/11449/233792
Resumo: Chronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD.
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spelling Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogscaninekidneymagnesium homeostasisnephrologyChronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD.Veterinary Teaching Hospital/Animal Science Graduate Program Franca University (UNIFRAN)Graduate Program in Veterinary Science (PPGCV)/College of Veterinary Medicine (FAMEV) Federal University of Uberlândia (UFU)Veterinary Medicine Graduate Program/School of Veterinary Medicine and Animal Science (FMVZ) Paulista State University (UNESP)Department of Veterinary Clinic and Surgery Paulista State University (UNESP)Veterinary Medicine Graduate Program/School of Veterinary Medicine and Animal Science (FMVZ) Paulista State University (UNESP)Department of Veterinary Clinic and Surgery Paulista State University (UNESP)Franca University (UNIFRAN)Universidade Federal de Uberlândia (UFU)Universidade Estadual Paulista (UNESP)de Lima, Charles SilvaFerreira, Karina Rodrigues GomesBorin-Crivellenti, SofiaMaia, Suellen Rodrigues [UNESP]Santana, Aureo Evangelista [UNESP]Crivellenti, Leandro Zuccolotto2022-05-01T10:18:58Z2022-05-01T10:18:58Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.tcam.2021.100588Topics in Companion Animal Medicine, v. 46.1938-9736http://hdl.handle.net/11449/23379210.1016/j.tcam.2021.1005882-s2.0-85118944087Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengTopics in Companion Animal Medicineinfo:eu-repo/semantics/openAccess2024-06-06T14:10:47Zoai:repositorio.unesp.br:11449/233792Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:11:15.292492Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
title Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
spellingShingle Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
de Lima, Charles Silva
canine
kidney
magnesium homeostasis
nephrology
title_short Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
title_full Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
title_fullStr Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
title_full_unstemmed Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
title_sort Renal Magnesium Handling: A Comparison Between Dogs With Chronic Kidney Disease and Healthy Elderly Dogs
author de Lima, Charles Silva
author_facet de Lima, Charles Silva
Ferreira, Karina Rodrigues Gomes
Borin-Crivellenti, Sofia
Maia, Suellen Rodrigues [UNESP]
Santana, Aureo Evangelista [UNESP]
Crivellenti, Leandro Zuccolotto
author_role author
author2 Ferreira, Karina Rodrigues Gomes
Borin-Crivellenti, Sofia
Maia, Suellen Rodrigues [UNESP]
Santana, Aureo Evangelista [UNESP]
Crivellenti, Leandro Zuccolotto
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Franca University (UNIFRAN)
Universidade Federal de Uberlândia (UFU)
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv de Lima, Charles Silva
Ferreira, Karina Rodrigues Gomes
Borin-Crivellenti, Sofia
Maia, Suellen Rodrigues [UNESP]
Santana, Aureo Evangelista [UNESP]
Crivellenti, Leandro Zuccolotto
dc.subject.por.fl_str_mv canine
kidney
magnesium homeostasis
nephrology
topic canine
kidney
magnesium homeostasis
nephrology
description Chronic kidney disease (CKD) and aging are known to possibly cause a progressive reduction in glomerular filtration rate, which may be associated with an increase in fractional excretion of electrolytes due to an adaptive response of the remaining functioning nephrons. However, the behavior of magnesium excretion has not been studied in CKD and healthy elderly dogs. The objective was to evaluate the fractional excretion of magnesium (FEMg) in dogs with (CKD) compared to healthy elderly dogs. Sixteen healthy elderly dogs and 43 dogs with CKD were divided into 3 groups (CKD 2 [n = 14], CKD 3 [n = 17], CKD 4 [n = 12]), in accordance with the current International Renal Interest Society (IRIS) criteria that were used in this study. Blood samples were obtained by jugular venipuncture and urine samples were obtained by cystocentesis. The FEMg was evaluated at a single time point in both urine and blood samples. FEMg was significantly higher in dogs with CKD compared to healthy elderly dogs, especially in advanced stages. This preliminary study demonstrates that FEMg may be altered in dogs with CKD. Further research is warranted to elucidate magnesium's potential role in cardiovascular and arterial calcification in dogs with CKD as observed in humans with CKD.
publishDate 2022
dc.date.none.fl_str_mv 2022-05-01T10:18:58Z
2022-05-01T10:18:58Z
2022-01-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.tcam.2021.100588
Topics in Companion Animal Medicine, v. 46.
1938-9736
http://hdl.handle.net/11449/233792
10.1016/j.tcam.2021.100588
2-s2.0-85118944087
url http://dx.doi.org/10.1016/j.tcam.2021.100588
http://hdl.handle.net/11449/233792
identifier_str_mv Topics in Companion Animal Medicine, v. 46.
1938-9736
10.1016/j.tcam.2021.100588
2-s2.0-85118944087
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Topics in Companion Animal Medicine
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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