Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1755-7682-5-19 http://hdl.handle.net/11449/73393 |
Resumo: | Background: We evaluated the presence of ductal carcinoma in situ (DCIS) in core needle biopsies (CNB) from invasive ductal lesions. Methods: Retrospective study, which analyzed 90 cases of invasive ductal carcinoma lesions. The percentage of DCIS was quantified in each specimens obtained from CNB, which were compared to the surgical specimens. CNB and surgical specimens were evaluated by the same pathologist, and the percentage of DCIS in CNB was evaluated (percentage) and divided into categories. We considered the following parameters regarding the amount of DCIS: 1 = 0; 2 = 1 for 5%; 3 = 6 for 24%; 4 = 25 for 50%; 5 = 51 for 75% and 6 = 76 for 99%. The number of fragments and the histological pattern of DCIS was found. Results: We found the following results regarding the distribution of the percentage of DCIS in the CNB: 1 = 63.3%; 2 = 12.2%; 3 = 12.2%; 4 = 5.6%; 5 = 1.1% and 6 = 5.6%. The logistic regression analysis showed that CNB percentages above 45% reflected the presence of DCIS in the surgical specimen in 100% of the cases (p<0.001), with a specificity of 100%, accuracy of 83.3% and false positive rate of 0% (p <0.001). Conclusion: There is direct relationship between extensive intraductal component in the surgical specimen when the core biopsy shows 45% or more of the DCI or microinvasive in the material examined. © 2012 Barbalaco Neto et al. |
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Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimenaccuracyclinical evaluationcontrolled studydisease associationfemalehumanhuman tissueintraductal carcinomalogistic regression analysismajor clinical studyneedle biopsypathologistBackground: We evaluated the presence of ductal carcinoma in situ (DCIS) in core needle biopsies (CNB) from invasive ductal lesions. Methods: Retrospective study, which analyzed 90 cases of invasive ductal carcinoma lesions. The percentage of DCIS was quantified in each specimens obtained from CNB, which were compared to the surgical specimens. CNB and surgical specimens were evaluated by the same pathologist, and the percentage of DCIS in CNB was evaluated (percentage) and divided into categories. We considered the following parameters regarding the amount of DCIS: 1 = 0; 2 = 1 for 5%; 3 = 6 for 24%; 4 = 25 for 50%; 5 = 51 for 75% and 6 = 76 for 99%. The number of fragments and the histological pattern of DCIS was found. Results: We found the following results regarding the distribution of the percentage of DCIS in the CNB: 1 = 63.3%; 2 = 12.2%; 3 = 12.2%; 4 = 5.6%; 5 = 1.1% and 6 = 5.6%. The logistic regression analysis showed that CNB percentages above 45% reflected the presence of DCIS in the surgical specimen in 100% of the cases (p<0.001), with a specificity of 100%, accuracy of 83.3% and false positive rate of 0% (p <0.001). Conclusion: There is direct relationship between extensive intraductal component in the surgical specimen when the core biopsy shows 45% or more of the DCI or microinvasive in the material examined. © 2012 Barbalaco Neto et al.Departamento de Mastologia Faculdade de Medicina do ABC, Avenida Príncipe de Gales, 821, Santo André, SP, 09060-650Departamento de Anatomia Patolágica Faculdade de Medicina do ABC, Avenida Príncipe de Gales, 821, Santo André, SP, 09060-650Departamento de Hematologia e Oncologia Faculdade de Medicina do ABC, Avenida Príncipe de Gales, 821, Santo André, SP, 09060-650Laboratário de Escrita Científica Departamento de Morfologia e Fisiologia Faculdade de Medicina do ABC, Avenida Príncipe de Gales, 821, Santo André, SP, 09060-650Departamento de Fonoaudiologia Faculdade de Filosofia e Ciências Universidade Estadual Paulista, Avenida Hygino Muzzi Filho, 747, Marília, SP, 17525-900Departamento de Morfologia e Fisiologia Faculdade de Medicina do ABC, Av. Príncipe de Gales, 821, Santo André, SP, 09060-650Departamento de Fonoaudiologia Faculdade de Filosofia e Ciências Universidade Estadual Paulista, Avenida Hygino Muzzi Filho, 747, Marília, SP, 17525-900Faculdade de Medicina do ABC (FMABC)Universidade Estadual Paulista (Unesp)Barbalaco Neto, GuerinoRossetti, ClaudiaFonseca, Fernando L.A.Valenti, Vitor Engrácia [UNESP]De Abreu, Luiz Carlos [UNESP]2014-05-27T11:26:51Z2014-05-27T11:26:51Z2012-06-22info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1186/1755-7682-5-19International Archives of Medicine, v. 5, n. 1, 2012.1755-7682http://hdl.handle.net/11449/7339310.1186/1755-7682-5-192-s2.0-848623093102-s2.0-84862309310.pdfScopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Archives of Medicine0,237info:eu-repo/semantics/openAccess2024-08-09T17:39:28Zoai:repositorio.unesp.br:11449/73393Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-09T17:39:28Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen |
title |
Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen |
spellingShingle |
Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen Barbalaco Neto, Guerino accuracy clinical evaluation controlled study disease association female human human tissue intraductal carcinoma logistic regression analysis major clinical study needle biopsy pathologist |
title_short |
Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen |
title_full |
Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen |
title_fullStr |
Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen |
title_full_unstemmed |
Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen |
title_sort |
Ductal carcinoma in situ in core needle biopsies and its association with extensive in situ component in the surgical specimen |
author |
Barbalaco Neto, Guerino |
author_facet |
Barbalaco Neto, Guerino Rossetti, Claudia Fonseca, Fernando L.A. Valenti, Vitor Engrácia [UNESP] De Abreu, Luiz Carlos [UNESP] |
author_role |
author |
author2 |
Rossetti, Claudia Fonseca, Fernando L.A. Valenti, Vitor Engrácia [UNESP] De Abreu, Luiz Carlos [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Faculdade de Medicina do ABC (FMABC) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Barbalaco Neto, Guerino Rossetti, Claudia Fonseca, Fernando L.A. Valenti, Vitor Engrácia [UNESP] De Abreu, Luiz Carlos [UNESP] |
dc.subject.por.fl_str_mv |
accuracy clinical evaluation controlled study disease association female human human tissue intraductal carcinoma logistic regression analysis major clinical study needle biopsy pathologist |
topic |
accuracy clinical evaluation controlled study disease association female human human tissue intraductal carcinoma logistic regression analysis major clinical study needle biopsy pathologist |
description |
Background: We evaluated the presence of ductal carcinoma in situ (DCIS) in core needle biopsies (CNB) from invasive ductal lesions. Methods: Retrospective study, which analyzed 90 cases of invasive ductal carcinoma lesions. The percentage of DCIS was quantified in each specimens obtained from CNB, which were compared to the surgical specimens. CNB and surgical specimens were evaluated by the same pathologist, and the percentage of DCIS in CNB was evaluated (percentage) and divided into categories. We considered the following parameters regarding the amount of DCIS: 1 = 0; 2 = 1 for 5%; 3 = 6 for 24%; 4 = 25 for 50%; 5 = 51 for 75% and 6 = 76 for 99%. The number of fragments and the histological pattern of DCIS was found. Results: We found the following results regarding the distribution of the percentage of DCIS in the CNB: 1 = 63.3%; 2 = 12.2%; 3 = 12.2%; 4 = 5.6%; 5 = 1.1% and 6 = 5.6%. The logistic regression analysis showed that CNB percentages above 45% reflected the presence of DCIS in the surgical specimen in 100% of the cases (p<0.001), with a specificity of 100%, accuracy of 83.3% and false positive rate of 0% (p <0.001). Conclusion: There is direct relationship between extensive intraductal component in the surgical specimen when the core biopsy shows 45% or more of the DCI or microinvasive in the material examined. © 2012 Barbalaco Neto et al. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-06-22 2014-05-27T11:26:51Z 2014-05-27T11:26:51Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1755-7682-5-19 International Archives of Medicine, v. 5, n. 1, 2012. 1755-7682 http://hdl.handle.net/11449/73393 10.1186/1755-7682-5-19 2-s2.0-84862309310 2-s2.0-84862309310.pdf |
url |
http://dx.doi.org/10.1186/1755-7682-5-19 http://hdl.handle.net/11449/73393 |
identifier_str_mv |
International Archives of Medicine, v. 5, n. 1, 2012. 1755-7682 10.1186/1755-7682-5-19 2-s2.0-84862309310 2-s2.0-84862309310.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Archives of Medicine 0,237 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128152456658944 |