Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus)
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1071/RD17456 http://hdl.handle.net/11449/176536 |
Resumo: | Chrysin is a bioflavonoid found in fruits, flowers, tea, honey and wine, which has antioxidant, anti-inflammatory, antiallergic and anticarcinogenic properties. This flavone has also been considered as beneficial for reproduction due its testosterone-boosting potential. Thus, the aim of this study was to evaluate the effects of chrysin on the prostate and gonads of male and female adult gerbils. In addition, a comparative analysis of the effects of testosterone on these same organs was conducted. Ninety-day-old male and female gerbils were treated with chrysin (50 mg kg -1 day -1) or testosterone cypionate (1 mg kg -1 week -1) for 21 days. The ventral male prostate and female prostate were dissected out for morphological, morphometric-stereological and ultrastructural assays. Testes and ovaries were submitted to morphological and morphometric-stereological analyses. Chrysin treatment caused epithelial hyperplasia and stromal remodelling of the ventral male and female prostate. Ultrastructurally, male and female prostatic epithelial cells in the chrysin group presented marked development of the organelles involved in the biosynthetic-secretory pathway, whereas cellular toxicity was observed only in female glands. Chrysin preserved normal testicular morphology and increased the number of growing ovarian follicles. Comparatively, testosterone treatment was detrimental to the prostate and gonads, since foci of prostatic intraepithelial neoplasia and gonadal degeneration were observed in both sexes. Thus, under the experimental conditions of this study, chrysin was better tolerated than testosterone in the prostate and gonads. |
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Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus)fertilitymorphologyovaryprostate glandtestestestosteroneChrysin is a bioflavonoid found in fruits, flowers, tea, honey and wine, which has antioxidant, anti-inflammatory, antiallergic and anticarcinogenic properties. This flavone has also been considered as beneficial for reproduction due its testosterone-boosting potential. Thus, the aim of this study was to evaluate the effects of chrysin on the prostate and gonads of male and female adult gerbils. In addition, a comparative analysis of the effects of testosterone on these same organs was conducted. Ninety-day-old male and female gerbils were treated with chrysin (50 mg kg -1 day -1) or testosterone cypionate (1 mg kg -1 week -1) for 21 days. The ventral male prostate and female prostate were dissected out for morphological, morphometric-stereological and ultrastructural assays. Testes and ovaries were submitted to morphological and morphometric-stereological analyses. Chrysin treatment caused epithelial hyperplasia and stromal remodelling of the ventral male and female prostate. Ultrastructurally, male and female prostatic epithelial cells in the chrysin group presented marked development of the organelles involved in the biosynthetic-secretory pathway, whereas cellular toxicity was observed only in female glands. Chrysin preserved normal testicular morphology and increased the number of growing ovarian follicles. Comparatively, testosterone treatment was detrimental to the prostate and gonads, since foci of prostatic intraepithelial neoplasia and gonadal degeneration were observed in both sexes. Thus, under the experimental conditions of this study, chrysin was better tolerated than testosterone in the prostate and gonads.Laboratory of Microscopy and Microanalysis Department of Biology State University of São Paulo (UNESP), Rua Cristóvão Colombo, 2265Laboratory of Microscopy Applied to Reproduction Department of Histology Embryology and Cell Biology Institute of Biological Sciences Federal University of GoiásLaboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Paulo State University (UNESP), Rua Cristóvão Colombo, 2265Laboratory of Microscopy and Microanalysis Department of Biology State University of São Paulo (UNESP), Rua Cristóvão Colombo, 2265Laboratory of Green and Medicinal Chemistry Department of Chemistry and Environmental Sciences Institute of Biosciences Humanities and Exact Sciences (IBILCE) São Paulo State University (UNESP), Rua Cristóvão Colombo, 2265Universidade Estadual Paulista (Unesp)Universidade Federal de Goiás (UFG)Campos, Mônica S. [UNESP]Ribeiro, Naiara C. S.De Lima, Rodrigo F.Santos, Mariana B. [UNESP]Vilamaior, Patrícia S. L. [UNESP]Regasini, Luis O. [UNESP]Biancardi, Manoel F.Taboga, Sebastião R. [UNESP]Santos, Fernanda C. A.2018-12-11T17:21:15Z2018-12-11T17:21:15Z2018-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1180-1191http://dx.doi.org/10.1071/RD17456Reproduction, Fertility and Development, v. 30, n. 9, p. 1180-1191, 2018.1448-59901031-3613http://hdl.handle.net/11449/17653610.1071/RD174562-s2.0-8504933442670663581237904340000-0001-9559-5497Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengReproduction, Fertility and Development0,681info:eu-repo/semantics/openAccess2024-04-11T19:33:50Zoai:repositorio.unesp.br:11449/176536Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T13:49:29.738636Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus) |
title |
Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus) |
spellingShingle |
Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus) Campos, Mônica S. [UNESP] fertility morphology ovary prostate gland testes testosterone |
title_short |
Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus) |
title_full |
Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus) |
title_fullStr |
Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus) |
title_full_unstemmed |
Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus) |
title_sort |
Anabolic effects of chrysin on the ventral male prostate and female prostate of adult gerbils (Meriones unguiculatus) |
author |
Campos, Mônica S. [UNESP] |
author_facet |
Campos, Mônica S. [UNESP] Ribeiro, Naiara C. S. De Lima, Rodrigo F. Santos, Mariana B. [UNESP] Vilamaior, Patrícia S. L. [UNESP] Regasini, Luis O. [UNESP] Biancardi, Manoel F. Taboga, Sebastião R. [UNESP] Santos, Fernanda C. A. |
author_role |
author |
author2 |
Ribeiro, Naiara C. S. De Lima, Rodrigo F. Santos, Mariana B. [UNESP] Vilamaior, Patrícia S. L. [UNESP] Regasini, Luis O. [UNESP] Biancardi, Manoel F. Taboga, Sebastião R. [UNESP] Santos, Fernanda C. A. |
author2_role |
author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Federal de Goiás (UFG) |
dc.contributor.author.fl_str_mv |
Campos, Mônica S. [UNESP] Ribeiro, Naiara C. S. De Lima, Rodrigo F. Santos, Mariana B. [UNESP] Vilamaior, Patrícia S. L. [UNESP] Regasini, Luis O. [UNESP] Biancardi, Manoel F. Taboga, Sebastião R. [UNESP] Santos, Fernanda C. A. |
dc.subject.por.fl_str_mv |
fertility morphology ovary prostate gland testes testosterone |
topic |
fertility morphology ovary prostate gland testes testosterone |
description |
Chrysin is a bioflavonoid found in fruits, flowers, tea, honey and wine, which has antioxidant, anti-inflammatory, antiallergic and anticarcinogenic properties. This flavone has also been considered as beneficial for reproduction due its testosterone-boosting potential. Thus, the aim of this study was to evaluate the effects of chrysin on the prostate and gonads of male and female adult gerbils. In addition, a comparative analysis of the effects of testosterone on these same organs was conducted. Ninety-day-old male and female gerbils were treated with chrysin (50 mg kg -1 day -1) or testosterone cypionate (1 mg kg -1 week -1) for 21 days. The ventral male prostate and female prostate were dissected out for morphological, morphometric-stereological and ultrastructural assays. Testes and ovaries were submitted to morphological and morphometric-stereological analyses. Chrysin treatment caused epithelial hyperplasia and stromal remodelling of the ventral male and female prostate. Ultrastructurally, male and female prostatic epithelial cells in the chrysin group presented marked development of the organelles involved in the biosynthetic-secretory pathway, whereas cellular toxicity was observed only in female glands. Chrysin preserved normal testicular morphology and increased the number of growing ovarian follicles. Comparatively, testosterone treatment was detrimental to the prostate and gonads, since foci of prostatic intraepithelial neoplasia and gonadal degeneration were observed in both sexes. Thus, under the experimental conditions of this study, chrysin was better tolerated than testosterone in the prostate and gonads. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-12-11T17:21:15Z 2018-12-11T17:21:15Z 2018-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1071/RD17456 Reproduction, Fertility and Development, v. 30, n. 9, p. 1180-1191, 2018. 1448-5990 1031-3613 http://hdl.handle.net/11449/176536 10.1071/RD17456 2-s2.0-85049334426 7066358123790434 0000-0001-9559-5497 |
url |
http://dx.doi.org/10.1071/RD17456 http://hdl.handle.net/11449/176536 |
identifier_str_mv |
Reproduction, Fertility and Development, v. 30, n. 9, p. 1180-1191, 2018. 1448-5990 1031-3613 10.1071/RD17456 2-s2.0-85049334426 7066358123790434 0000-0001-9559-5497 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Reproduction, Fertility and Development 0,681 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1180-1191 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128279604887552 |