Metabolic syndrome markers in wistar rats of different ages
Autor(a) principal: | |
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Data de Publicação: | 2012 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1186/1758-5996-4-16 http://hdl.handle.net/11449/20915 |
Resumo: | In recent decades, metabolic syndrome has become a public health problem throughout the world. Longitudinal studies in humans have several limitations due to the invasive nature of certain analyses and the size and randomness of the study populations. Thus, animal models that are able to mimic human physiological responses could aid in investigating metabolic disease. Thus, the present study was designed to analyze metabolic syndrome markers in albino Wistar rats (Rattus norvegicus) of different ages. The following parameters were assessed at two (young), four (adult), six (adult), and twelve (mature) months of age: glucose tolerance (glucose tolerance test); insulin sensitivity (insulin tolerance test); fasting serum glucose, triglycerides, total cholesterol, HDL cholestero, and LDL cholesterol concentrations; glucose uptake in isolated soleus muscle; and total lipid concentration in subcutaneous, mesenteric, and retroperitoneal adipose tissue. We found that aging triggered signs of metabolic syndrome in Wistar rats. For example, mature rats showed a significant increase in body weight that was associated. In addition, mature rats showed an increase in the serum concentration of triglycerides, total cholesterol, and LDL cholesterol, which is characteristic of dyslipidemia. There was also an increase in serum glucose compared with the younger groups of animals. Therefore, aging Wistar rats appear to be an interesting model to study the changes related to metabolic syndrome. |
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Metabolic syndrome markers in wistar rats of different agesMetabolic syndromeBiochemical parametersMetabolismAgingWistar ratsIn recent decades, metabolic syndrome has become a public health problem throughout the world. Longitudinal studies in humans have several limitations due to the invasive nature of certain analyses and the size and randomness of the study populations. Thus, animal models that are able to mimic human physiological responses could aid in investigating metabolic disease. Thus, the present study was designed to analyze metabolic syndrome markers in albino Wistar rats (Rattus norvegicus) of different ages. The following parameters were assessed at two (young), four (adult), six (adult), and twelve (mature) months of age: glucose tolerance (glucose tolerance test); insulin sensitivity (insulin tolerance test); fasting serum glucose, triglycerides, total cholesterol, HDL cholestero, and LDL cholesterol concentrations; glucose uptake in isolated soleus muscle; and total lipid concentration in subcutaneous, mesenteric, and retroperitoneal adipose tissue. We found that aging triggered signs of metabolic syndrome in Wistar rats. For example, mature rats showed a significant increase in body weight that was associated. In addition, mature rats showed an increase in the serum concentration of triglycerides, total cholesterol, and LDL cholesterol, which is characteristic of dyslipidemia. There was also an increase in serum glucose compared with the younger groups of animals. Therefore, aging Wistar rats appear to be an interesting model to study the changes related to metabolic syndrome.Univ Estadual Paulista, UNESP, São Paulo State Univ, Dept Phys Educ, Rio Claro, SP, BrazilUniv Estadual Paulista, UNESP, São Paulo State Univ, Dept Phys Educ, Rio Claro, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Ghezzi, Ana Carolina [UNESP]Cambri, Lucieli Teresa [UNESP]Botezelli, Jose Diego [UNESP]Ribeiro, Carla [UNESP]Dalia, Rodrigo Augusto [UNESP]Rostom de Mello, Maria Alice [UNESP]2013-09-30T18:49:33Z2014-05-20T13:58:55Z2013-09-30T18:49:33Z2014-05-20T13:58:55Z2012-04-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1186/1758-5996-4-16Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012.1758-5996http://hdl.handle.net/11449/2091510.1186/1758-5996-4-16WOS:000310293600001WOS000310293600001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDiabetology & Metabolic Syndrome2.4130,943info:eu-repo/semantics/openAccess2023-11-09T06:08:16Zoai:repositorio.unesp.br:11449/20915Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:12:23.498920Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Metabolic syndrome markers in wistar rats of different ages |
title |
Metabolic syndrome markers in wistar rats of different ages |
spellingShingle |
Metabolic syndrome markers in wistar rats of different ages Ghezzi, Ana Carolina [UNESP] Metabolic syndrome Biochemical parameters Metabolism Aging Wistar rats |
title_short |
Metabolic syndrome markers in wistar rats of different ages |
title_full |
Metabolic syndrome markers in wistar rats of different ages |
title_fullStr |
Metabolic syndrome markers in wistar rats of different ages |
title_full_unstemmed |
Metabolic syndrome markers in wistar rats of different ages |
title_sort |
Metabolic syndrome markers in wistar rats of different ages |
author |
Ghezzi, Ana Carolina [UNESP] |
author_facet |
Ghezzi, Ana Carolina [UNESP] Cambri, Lucieli Teresa [UNESP] Botezelli, Jose Diego [UNESP] Ribeiro, Carla [UNESP] Dalia, Rodrigo Augusto [UNESP] Rostom de Mello, Maria Alice [UNESP] |
author_role |
author |
author2 |
Cambri, Lucieli Teresa [UNESP] Botezelli, Jose Diego [UNESP] Ribeiro, Carla [UNESP] Dalia, Rodrigo Augusto [UNESP] Rostom de Mello, Maria Alice [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Ghezzi, Ana Carolina [UNESP] Cambri, Lucieli Teresa [UNESP] Botezelli, Jose Diego [UNESP] Ribeiro, Carla [UNESP] Dalia, Rodrigo Augusto [UNESP] Rostom de Mello, Maria Alice [UNESP] |
dc.subject.por.fl_str_mv |
Metabolic syndrome Biochemical parameters Metabolism Aging Wistar rats |
topic |
Metabolic syndrome Biochemical parameters Metabolism Aging Wistar rats |
description |
In recent decades, metabolic syndrome has become a public health problem throughout the world. Longitudinal studies in humans have several limitations due to the invasive nature of certain analyses and the size and randomness of the study populations. Thus, animal models that are able to mimic human physiological responses could aid in investigating metabolic disease. Thus, the present study was designed to analyze metabolic syndrome markers in albino Wistar rats (Rattus norvegicus) of different ages. The following parameters were assessed at two (young), four (adult), six (adult), and twelve (mature) months of age: glucose tolerance (glucose tolerance test); insulin sensitivity (insulin tolerance test); fasting serum glucose, triglycerides, total cholesterol, HDL cholestero, and LDL cholesterol concentrations; glucose uptake in isolated soleus muscle; and total lipid concentration in subcutaneous, mesenteric, and retroperitoneal adipose tissue. We found that aging triggered signs of metabolic syndrome in Wistar rats. For example, mature rats showed a significant increase in body weight that was associated. In addition, mature rats showed an increase in the serum concentration of triglycerides, total cholesterol, and LDL cholesterol, which is characteristic of dyslipidemia. There was also an increase in serum glucose compared with the younger groups of animals. Therefore, aging Wistar rats appear to be an interesting model to study the changes related to metabolic syndrome. |
publishDate |
2012 |
dc.date.none.fl_str_mv |
2012-04-27 2013-09-30T18:49:33Z 2013-09-30T18:49:33Z 2014-05-20T13:58:55Z 2014-05-20T13:58:55Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1186/1758-5996-4-16 Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012. 1758-5996 http://hdl.handle.net/11449/20915 10.1186/1758-5996-4-16 WOS:000310293600001 WOS000310293600001.pdf |
url |
http://dx.doi.org/10.1186/1758-5996-4-16 http://hdl.handle.net/11449/20915 |
identifier_str_mv |
Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012. 1758-5996 10.1186/1758-5996-4-16 WOS:000310293600001 WOS000310293600001.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Diabetology & Metabolic Syndrome 2.413 0,943 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
7 application/pdf |
dc.publisher.none.fl_str_mv |
Biomed Central Ltd. |
publisher.none.fl_str_mv |
Biomed Central Ltd. |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128772334944256 |