Metabolic syndrome markers in wistar rats of different ages

Detalhes bibliográficos
Autor(a) principal: Ghezzi, Ana Carolina [UNESP]
Data de Publicação: 2012
Outros Autores: Cambri, Lucieli Teresa [UNESP], Botezelli, Jose Diego [UNESP], Ribeiro, Carla [UNESP], Dalia, Rodrigo Augusto [UNESP], Rostom de Mello, Maria Alice [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1186/1758-5996-4-16
http://hdl.handle.net/11449/20915
Resumo: In recent decades, metabolic syndrome has become a public health problem throughout the world. Longitudinal studies in humans have several limitations due to the invasive nature of certain analyses and the size and randomness of the study populations. Thus, animal models that are able to mimic human physiological responses could aid in investigating metabolic disease. Thus, the present study was designed to analyze metabolic syndrome markers in albino Wistar rats (Rattus norvegicus) of different ages. The following parameters were assessed at two (young), four (adult), six (adult), and twelve (mature) months of age: glucose tolerance (glucose tolerance test); insulin sensitivity (insulin tolerance test); fasting serum glucose, triglycerides, total cholesterol, HDL cholestero, and LDL cholesterol concentrations; glucose uptake in isolated soleus muscle; and total lipid concentration in subcutaneous, mesenteric, and retroperitoneal adipose tissue. We found that aging triggered signs of metabolic syndrome in Wistar rats. For example, mature rats showed a significant increase in body weight that was associated. In addition, mature rats showed an increase in the serum concentration of triglycerides, total cholesterol, and LDL cholesterol, which is characteristic of dyslipidemia. There was also an increase in serum glucose compared with the younger groups of animals. Therefore, aging Wistar rats appear to be an interesting model to study the changes related to metabolic syndrome.
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spelling Metabolic syndrome markers in wistar rats of different agesMetabolic syndromeBiochemical parametersMetabolismAgingWistar ratsIn recent decades, metabolic syndrome has become a public health problem throughout the world. Longitudinal studies in humans have several limitations due to the invasive nature of certain analyses and the size and randomness of the study populations. Thus, animal models that are able to mimic human physiological responses could aid in investigating metabolic disease. Thus, the present study was designed to analyze metabolic syndrome markers in albino Wistar rats (Rattus norvegicus) of different ages. The following parameters were assessed at two (young), four (adult), six (adult), and twelve (mature) months of age: glucose tolerance (glucose tolerance test); insulin sensitivity (insulin tolerance test); fasting serum glucose, triglycerides, total cholesterol, HDL cholestero, and LDL cholesterol concentrations; glucose uptake in isolated soleus muscle; and total lipid concentration in subcutaneous, mesenteric, and retroperitoneal adipose tissue. We found that aging triggered signs of metabolic syndrome in Wistar rats. For example, mature rats showed a significant increase in body weight that was associated. In addition, mature rats showed an increase in the serum concentration of triglycerides, total cholesterol, and LDL cholesterol, which is characteristic of dyslipidemia. There was also an increase in serum glucose compared with the younger groups of animals. Therefore, aging Wistar rats appear to be an interesting model to study the changes related to metabolic syndrome.Univ Estadual Paulista, UNESP, São Paulo State Univ, Dept Phys Educ, Rio Claro, SP, BrazilUniv Estadual Paulista, UNESP, São Paulo State Univ, Dept Phys Educ, Rio Claro, SP, BrazilBiomed Central Ltd.Universidade Estadual Paulista (Unesp)Ghezzi, Ana Carolina [UNESP]Cambri, Lucieli Teresa [UNESP]Botezelli, Jose Diego [UNESP]Ribeiro, Carla [UNESP]Dalia, Rodrigo Augusto [UNESP]Rostom de Mello, Maria Alice [UNESP]2013-09-30T18:49:33Z2014-05-20T13:58:55Z2013-09-30T18:49:33Z2014-05-20T13:58:55Z2012-04-27info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article7application/pdfhttp://dx.doi.org/10.1186/1758-5996-4-16Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012.1758-5996http://hdl.handle.net/11449/2091510.1186/1758-5996-4-16WOS:000310293600001WOS000310293600001.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengDiabetology & Metabolic Syndrome2.4130,943info:eu-repo/semantics/openAccess2023-11-09T06:08:16Zoai:repositorio.unesp.br:11449/20915Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T17:12:23.498920Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Metabolic syndrome markers in wistar rats of different ages
title Metabolic syndrome markers in wistar rats of different ages
spellingShingle Metabolic syndrome markers in wistar rats of different ages
Ghezzi, Ana Carolina [UNESP]
Metabolic syndrome
Biochemical parameters
Metabolism
Aging
Wistar rats
title_short Metabolic syndrome markers in wistar rats of different ages
title_full Metabolic syndrome markers in wistar rats of different ages
title_fullStr Metabolic syndrome markers in wistar rats of different ages
title_full_unstemmed Metabolic syndrome markers in wistar rats of different ages
title_sort Metabolic syndrome markers in wistar rats of different ages
author Ghezzi, Ana Carolina [UNESP]
author_facet Ghezzi, Ana Carolina [UNESP]
Cambri, Lucieli Teresa [UNESP]
Botezelli, Jose Diego [UNESP]
Ribeiro, Carla [UNESP]
Dalia, Rodrigo Augusto [UNESP]
Rostom de Mello, Maria Alice [UNESP]
author_role author
author2 Cambri, Lucieli Teresa [UNESP]
Botezelli, Jose Diego [UNESP]
Ribeiro, Carla [UNESP]
Dalia, Rodrigo Augusto [UNESP]
Rostom de Mello, Maria Alice [UNESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Ghezzi, Ana Carolina [UNESP]
Cambri, Lucieli Teresa [UNESP]
Botezelli, Jose Diego [UNESP]
Ribeiro, Carla [UNESP]
Dalia, Rodrigo Augusto [UNESP]
Rostom de Mello, Maria Alice [UNESP]
dc.subject.por.fl_str_mv Metabolic syndrome
Biochemical parameters
Metabolism
Aging
Wistar rats
topic Metabolic syndrome
Biochemical parameters
Metabolism
Aging
Wistar rats
description In recent decades, metabolic syndrome has become a public health problem throughout the world. Longitudinal studies in humans have several limitations due to the invasive nature of certain analyses and the size and randomness of the study populations. Thus, animal models that are able to mimic human physiological responses could aid in investigating metabolic disease. Thus, the present study was designed to analyze metabolic syndrome markers in albino Wistar rats (Rattus norvegicus) of different ages. The following parameters were assessed at two (young), four (adult), six (adult), and twelve (mature) months of age: glucose tolerance (glucose tolerance test); insulin sensitivity (insulin tolerance test); fasting serum glucose, triglycerides, total cholesterol, HDL cholestero, and LDL cholesterol concentrations; glucose uptake in isolated soleus muscle; and total lipid concentration in subcutaneous, mesenteric, and retroperitoneal adipose tissue. We found that aging triggered signs of metabolic syndrome in Wistar rats. For example, mature rats showed a significant increase in body weight that was associated. In addition, mature rats showed an increase in the serum concentration of triglycerides, total cholesterol, and LDL cholesterol, which is characteristic of dyslipidemia. There was also an increase in serum glucose compared with the younger groups of animals. Therefore, aging Wistar rats appear to be an interesting model to study the changes related to metabolic syndrome.
publishDate 2012
dc.date.none.fl_str_mv 2012-04-27
2013-09-30T18:49:33Z
2013-09-30T18:49:33Z
2014-05-20T13:58:55Z
2014-05-20T13:58:55Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1186/1758-5996-4-16
Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012.
1758-5996
http://hdl.handle.net/11449/20915
10.1186/1758-5996-4-16
WOS:000310293600001
WOS000310293600001.pdf
url http://dx.doi.org/10.1186/1758-5996-4-16
http://hdl.handle.net/11449/20915
identifier_str_mv Diabetology & Metabolic Syndrome. London: Biomed Central Ltd., v. 4, p. 7, 2012.
1758-5996
10.1186/1758-5996-4-16
WOS:000310293600001
WOS000310293600001.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Diabetology & Metabolic Syndrome
2.413
0,943
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 7
application/pdf
dc.publisher.none.fl_str_mv Biomed Central Ltd.
publisher.none.fl_str_mv Biomed Central Ltd.
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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