Novel polymeric dressing to the treatment of infected chronic wound
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s00253-019-09699-x http://hdl.handle.net/11449/190322 |
Resumo: | Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment. |
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Novel polymeric dressing to the treatment of infected chronic woundAntibioticMoxifloxacinNatural rubber latexSkin infectionWound healingNatural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Institute of Chemistry São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)School of Medicine São Paulo University (USP)School of Pharmaceutical Science São Paulo University (USP)Faculty of Agricultural Sciences São Paulo State University (UNESP)Institute of Chemistry São Paulo State University (UNESP)School of Pharmaceutical Sciences São Paulo State University (UNESP)Faculty of Agricultural Sciences São Paulo State University (UNESP)CNPq: 134018/2016-8FAPERJ: 2011/17411-8FAPESP: 2014/17526-8CNPq: 470261/2012-9Universidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Garms, Bruna Cambraia [UNESP]Borges, Felipe Azevedo [UNESP]de Barros, Natan Roberto [UNESP]Marcelino, Mônica Yonashiro [UNESP]Leite, Marcel NaniDel Arco, Marina Constantede Souza Salvador, Sérgio LuizPegorin, Giovana Sant’Ana [UNESP]Oliveira, Kassandra Sussi Mustafé [UNESP]Frade, Marco Andrey CiprianiHerculano, Rondinelli Donizetti [UNESP]2019-10-06T17:09:27Z2019-10-06T17:09:27Z2019-06-18info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article4767-4778http://dx.doi.org/10.1007/s00253-019-09699-xApplied Microbiology and Biotechnology, v. 103, n. 12, p. 4767-4778, 2019.1432-06140175-7598http://hdl.handle.net/11449/19032210.1007/s00253-019-09699-x2-s2.0-85065483629Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengApplied Microbiology and Biotechnologyinfo:eu-repo/semantics/openAccess2024-06-13T17:38:32Zoai:repositorio.unesp.br:11449/190322Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T19:33:15.019729Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Novel polymeric dressing to the treatment of infected chronic wound |
title |
Novel polymeric dressing to the treatment of infected chronic wound |
spellingShingle |
Novel polymeric dressing to the treatment of infected chronic wound Garms, Bruna Cambraia [UNESP] Antibiotic Moxifloxacin Natural rubber latex Skin infection Wound healing |
title_short |
Novel polymeric dressing to the treatment of infected chronic wound |
title_full |
Novel polymeric dressing to the treatment of infected chronic wound |
title_fullStr |
Novel polymeric dressing to the treatment of infected chronic wound |
title_full_unstemmed |
Novel polymeric dressing to the treatment of infected chronic wound |
title_sort |
Novel polymeric dressing to the treatment of infected chronic wound |
author |
Garms, Bruna Cambraia [UNESP] |
author_facet |
Garms, Bruna Cambraia [UNESP] Borges, Felipe Azevedo [UNESP] de Barros, Natan Roberto [UNESP] Marcelino, Mônica Yonashiro [UNESP] Leite, Marcel Nani Del Arco, Marina Constante de Souza Salvador, Sérgio Luiz Pegorin, Giovana Sant’Ana [UNESP] Oliveira, Kassandra Sussi Mustafé [UNESP] Frade, Marco Andrey Cipriani Herculano, Rondinelli Donizetti [UNESP] |
author_role |
author |
author2 |
Borges, Felipe Azevedo [UNESP] de Barros, Natan Roberto [UNESP] Marcelino, Mônica Yonashiro [UNESP] Leite, Marcel Nani Del Arco, Marina Constante de Souza Salvador, Sérgio Luiz Pegorin, Giovana Sant’Ana [UNESP] Oliveira, Kassandra Sussi Mustafé [UNESP] Frade, Marco Andrey Cipriani Herculano, Rondinelli Donizetti [UNESP] |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Garms, Bruna Cambraia [UNESP] Borges, Felipe Azevedo [UNESP] de Barros, Natan Roberto [UNESP] Marcelino, Mônica Yonashiro [UNESP] Leite, Marcel Nani Del Arco, Marina Constante de Souza Salvador, Sérgio Luiz Pegorin, Giovana Sant’Ana [UNESP] Oliveira, Kassandra Sussi Mustafé [UNESP] Frade, Marco Andrey Cipriani Herculano, Rondinelli Donizetti [UNESP] |
dc.subject.por.fl_str_mv |
Antibiotic Moxifloxacin Natural rubber latex Skin infection Wound healing |
topic |
Antibiotic Moxifloxacin Natural rubber latex Skin infection Wound healing |
description |
Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-10-06T17:09:27Z 2019-10-06T17:09:27Z 2019-06-18 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s00253-019-09699-x Applied Microbiology and Biotechnology, v. 103, n. 12, p. 4767-4778, 2019. 1432-0614 0175-7598 http://hdl.handle.net/11449/190322 10.1007/s00253-019-09699-x 2-s2.0-85065483629 |
url |
http://dx.doi.org/10.1007/s00253-019-09699-x http://hdl.handle.net/11449/190322 |
identifier_str_mv |
Applied Microbiology and Biotechnology, v. 103, n. 12, p. 4767-4778, 2019. 1432-0614 0175-7598 10.1007/s00253-019-09699-x 2-s2.0-85065483629 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Applied Microbiology and Biotechnology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
4767-4778 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129085106290688 |