Associações anestésicas baseadas em fármacos dissociativos reduzem a pressão intraocular (PIO) em coelhos

• Autor(a) principal: Mattos-Junior, Ewaldo de
• Data de Publicação: 2014
• Outros Autores: Cunha, Olicies da, Moraes Barros, Luis Felipe, Hamad Minervino, Antonio Humberto, Nishimura, Lilian Toshiko, Dias, Luis Gustavo Gosuen Gonçalves [UNESP], Gaido Cortopassi, Silvia Renata
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.5433/1679-0359.2014v35n2p905; http://hdl.handle.net/11449/117607
• topic: Ketamine; midazolam; Oryctolagus cuniculus; tiletamine; xylazine; zolazepam

The aim of this study was evaluate the effects of three anesthetic combinations, ketamine-midazolam, ketamine-xylazine and tiletamine-zolazepam, on IOP in rabbits. In a experimental, blind, randomized, crossover study, six rabbits were anesthetized with each of 3 treatments in random order. Groups KM (ketamine, 30 mg/kg + midazolam, 1 mg/kg); KX (ketamine, 30 mg/kg + xylazine, 3 mg/kg); and TZ (tiletamine + zolazepam, 20 mg/kg). The drugs were mixed in the same syringe injected intramuscularly (IM) into the quadriceps muscle. IOP was measured before drug administration (baseline) and at 5-minute intervals for 30 minutes. The data were analyzed by a 2-way repeated measures ANOVA followed by Bonferroni test. All groups had significant decreases in IOP compared to baseline (p < 0.001). There was no difference between groups at any of the time points assessed (p > 0.05). Administration of either ketamine-midazolam, ketamine-xylazine, or tiletamine-zolazepam similarly decrease IOP in rabbits within 30 minutes of injection.