Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction

Detalhes bibliográficos
Autor(a) principal: de Souza Ramos, Juan Thomaz Gabriel [UNESP]
Data de Publicação: 2022
Outros Autores: Ferrari, Felipe Sanches [UNESP], Andrade, Morganna Freitas [UNESP], de Melo, Caroline Souto, Boas, Paulo José Fortes Villas [UNESP], Costa, Nara Aline, Pereira, Amanda Gomes [UNESP], Dorna, Mariana Souza [UNESP], Azevedo, Paula Schmidt [UNESP], Banerjee, Jay, Phillips, Bethan E., Atherton, Philip J., Polegato, Bertha Furlan [UNESP], Okoshi, Katashi [UNESP], Zanati, Silmeia Garcia [UNESP], Paiva, Sergio Alberto Rupp [UNESP], Zornoff, Leonardo Antonio Mamede [UNESP], Minicucci, Marcos Ferreira [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.exger.2021.111658
http://hdl.handle.net/11449/230064
Resumo: The objective of this study was to evaluate the association between frailty, evaluated by the Clinical Frailty Scale (CFS) and FRAIL scale, and C-terminal agrin fragment (CAF) levels with 3-month mortality following ST-segment elevation myocardial infarction (STEMI). This was a prospective observational study that included patients over the age of 18 years with STEMI admitted to the coronary intensive care unit. Within 48 h of admission, the CFS and FRAIL scale were applied and blood samples collected for serum CAF evaluation. Patients were followed for 3 months after hospital discharge, and mortality was recorded. One hundred and eleven patients were included; mean age was 62.3 ± 12.4 years, 61.3% were male and 11.7% died during the 3 months of follow-up. According to the CFS, 79.3% of the patients were classified as not frail, 12.6% as pre-frail and 8.1% as frail. According to the FRAIL scale, 31.5% of the patients were classified as not frail, 53.2% as pre-frail and 15.3% as frail. In univariate analysis, the CFS but not FRAIL scale was associated with mortality. In multiple logistic regression analysis, pre-frail/frail according to CFS (odds ratio [OR]: 6.118; CI 95%: 1.344–27.848; p = 0.019) and CAF levels (OR: 0.943; CI 95%: 0.896–0.992; p = 0.024) were associated with increased 3-month mortality. In a sub-analysis of 53 patients ≥65 years, CFS and CAF levels were associated with 3-month mortality. In conclusion, CAF levels and frailty determined by the CFS were associated with 3-month mortality after STEMI in the general and older population.
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spelling Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarctionAcute myocardial infarctionC-terminal agrin fragmentClinical frailty scaleFRAIL scaleThe objective of this study was to evaluate the association between frailty, evaluated by the Clinical Frailty Scale (CFS) and FRAIL scale, and C-terminal agrin fragment (CAF) levels with 3-month mortality following ST-segment elevation myocardial infarction (STEMI). This was a prospective observational study that included patients over the age of 18 years with STEMI admitted to the coronary intensive care unit. Within 48 h of admission, the CFS and FRAIL scale were applied and blood samples collected for serum CAF evaluation. Patients were followed for 3 months after hospital discharge, and mortality was recorded. One hundred and eleven patients were included; mean age was 62.3 ± 12.4 years, 61.3% were male and 11.7% died during the 3 months of follow-up. According to the CFS, 79.3% of the patients were classified as not frail, 12.6% as pre-frail and 8.1% as frail. According to the FRAIL scale, 31.5% of the patients were classified as not frail, 53.2% as pre-frail and 15.3% as frail. In univariate analysis, the CFS but not FRAIL scale was associated with mortality. In multiple logistic regression analysis, pre-frail/frail according to CFS (odds ratio [OR]: 6.118; CI 95%: 1.344–27.848; p = 0.019) and CAF levels (OR: 0.943; CI 95%: 0.896–0.992; p = 0.024) were associated with increased 3-month mortality. In a sub-analysis of 53 patients ≥65 years, CFS and CAF levels were associated with 3-month mortality. In conclusion, CAF levels and frailty determined by the CFS were associated with 3-month mortality after STEMI in the general and older population.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Estadual PaulistaConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Internal Medicine Department Botucatu Medical School Univ Estadual Paulista UNESPUniversity Hospital Botucatu Medical School Sao Paulo State University UNESPDepartment of Anesthesiology Complexo Hospitalar Santa Genoveva de UberlândiaFaculty of Nutrition UFG- Univ Federal de GoiásGeriatric Emergency Medicine University Hospitals of Leicester School of Health Science University of LeicesterMedical Research Council-Versus Arthritis Centre for Musculoskeletal Ageing Research and National Institute for Health Research (NIHR) Nottingham Biomedical Research Centre University of NottinghamInternal Medicine Department Botucatu Medical School Univ Estadual Paulista UNESPUniversity Hospital Botucatu Medical School Sao Paulo State University UNESPCNPq: 304298/2019-0Universidade Estadual Paulista (UNESP)Complexo Hospitalar Santa Genoveva de UberlândiaUFG- Univ Federal de GoiásUniversity of LeicesterUniversity of Nottinghamde Souza Ramos, Juan Thomaz Gabriel [UNESP]Ferrari, Felipe Sanches [UNESP]Andrade, Morganna Freitas [UNESP]de Melo, Caroline SoutoBoas, Paulo José Fortes Villas [UNESP]Costa, Nara AlinePereira, Amanda Gomes [UNESP]Dorna, Mariana Souza [UNESP]Azevedo, Paula Schmidt [UNESP]Banerjee, JayPhillips, Bethan E.Atherton, Philip J.Polegato, Bertha Furlan [UNESP]Okoshi, Katashi [UNESP]Zanati, Silmeia Garcia [UNESP]Paiva, Sergio Alberto Rupp [UNESP]Zornoff, Leonardo Antonio Mamede [UNESP]Minicucci, Marcos Ferreira [UNESP]2022-04-29T08:37:25Z2022-04-29T08:37:25Z2022-02-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1016/j.exger.2021.111658Experimental Gerontology, v. 158.1873-68150531-5565http://hdl.handle.net/11449/23006410.1016/j.exger.2021.1116582-s2.0-85121217131Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengExperimental Gerontologyinfo:eu-repo/semantics/openAccess2022-04-29T08:37:25Zoai:repositorio.unesp.br:11449/230064Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:37:25Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
title Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
spellingShingle Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
de Souza Ramos, Juan Thomaz Gabriel [UNESP]
Acute myocardial infarction
C-terminal agrin fragment
Clinical frailty scale
FRAIL scale
title_short Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
title_full Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
title_fullStr Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
title_full_unstemmed Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
title_sort Association between frailty and C-terminal agrin fragment with 3-month mortality following ST-elevation myocardial infarction
author de Souza Ramos, Juan Thomaz Gabriel [UNESP]
author_facet de Souza Ramos, Juan Thomaz Gabriel [UNESP]
Ferrari, Felipe Sanches [UNESP]
Andrade, Morganna Freitas [UNESP]
de Melo, Caroline Souto
Boas, Paulo José Fortes Villas [UNESP]
Costa, Nara Aline
Pereira, Amanda Gomes [UNESP]
Dorna, Mariana Souza [UNESP]
Azevedo, Paula Schmidt [UNESP]
Banerjee, Jay
Phillips, Bethan E.
Atherton, Philip J.
Polegato, Bertha Furlan [UNESP]
Okoshi, Katashi [UNESP]
Zanati, Silmeia Garcia [UNESP]
Paiva, Sergio Alberto Rupp [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Minicucci, Marcos Ferreira [UNESP]
author_role author
author2 Ferrari, Felipe Sanches [UNESP]
Andrade, Morganna Freitas [UNESP]
de Melo, Caroline Souto
Boas, Paulo José Fortes Villas [UNESP]
Costa, Nara Aline
Pereira, Amanda Gomes [UNESP]
Dorna, Mariana Souza [UNESP]
Azevedo, Paula Schmidt [UNESP]
Banerjee, Jay
Phillips, Bethan E.
Atherton, Philip J.
Polegato, Bertha Furlan [UNESP]
Okoshi, Katashi [UNESP]
Zanati, Silmeia Garcia [UNESP]
Paiva, Sergio Alberto Rupp [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Minicucci, Marcos Ferreira [UNESP]
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Complexo Hospitalar Santa Genoveva de Uberlândia
UFG- Univ Federal de Goiás
University of Leicester
University of Nottingham
dc.contributor.author.fl_str_mv de Souza Ramos, Juan Thomaz Gabriel [UNESP]
Ferrari, Felipe Sanches [UNESP]
Andrade, Morganna Freitas [UNESP]
de Melo, Caroline Souto
Boas, Paulo José Fortes Villas [UNESP]
Costa, Nara Aline
Pereira, Amanda Gomes [UNESP]
Dorna, Mariana Souza [UNESP]
Azevedo, Paula Schmidt [UNESP]
Banerjee, Jay
Phillips, Bethan E.
Atherton, Philip J.
Polegato, Bertha Furlan [UNESP]
Okoshi, Katashi [UNESP]
Zanati, Silmeia Garcia [UNESP]
Paiva, Sergio Alberto Rupp [UNESP]
Zornoff, Leonardo Antonio Mamede [UNESP]
Minicucci, Marcos Ferreira [UNESP]
dc.subject.por.fl_str_mv Acute myocardial infarction
C-terminal agrin fragment
Clinical frailty scale
FRAIL scale
topic Acute myocardial infarction
C-terminal agrin fragment
Clinical frailty scale
FRAIL scale
description The objective of this study was to evaluate the association between frailty, evaluated by the Clinical Frailty Scale (CFS) and FRAIL scale, and C-terminal agrin fragment (CAF) levels with 3-month mortality following ST-segment elevation myocardial infarction (STEMI). This was a prospective observational study that included patients over the age of 18 years with STEMI admitted to the coronary intensive care unit. Within 48 h of admission, the CFS and FRAIL scale were applied and blood samples collected for serum CAF evaluation. Patients were followed for 3 months after hospital discharge, and mortality was recorded. One hundred and eleven patients were included; mean age was 62.3 ± 12.4 years, 61.3% were male and 11.7% died during the 3 months of follow-up. According to the CFS, 79.3% of the patients were classified as not frail, 12.6% as pre-frail and 8.1% as frail. According to the FRAIL scale, 31.5% of the patients were classified as not frail, 53.2% as pre-frail and 15.3% as frail. In univariate analysis, the CFS but not FRAIL scale was associated with mortality. In multiple logistic regression analysis, pre-frail/frail according to CFS (odds ratio [OR]: 6.118; CI 95%: 1.344–27.848; p = 0.019) and CAF levels (OR: 0.943; CI 95%: 0.896–0.992; p = 0.024) were associated with increased 3-month mortality. In a sub-analysis of 53 patients ≥65 years, CFS and CAF levels were associated with 3-month mortality. In conclusion, CAF levels and frailty determined by the CFS were associated with 3-month mortality after STEMI in the general and older population.
publishDate 2022
dc.date.none.fl_str_mv 2022-04-29T08:37:25Z
2022-04-29T08:37:25Z
2022-02-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.exger.2021.111658
Experimental Gerontology, v. 158.
1873-6815
0531-5565
http://hdl.handle.net/11449/230064
10.1016/j.exger.2021.111658
2-s2.0-85121217131
url http://dx.doi.org/10.1016/j.exger.2021.111658
http://hdl.handle.net/11449/230064
identifier_str_mv Experimental Gerontology, v. 158.
1873-6815
0531-5565
10.1016/j.exger.2021.111658
2-s2.0-85121217131
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Experimental Gerontology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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