Comparison between S-ketamine and clonidine in caudal analgesia
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.5897/AJPP11.486 http://hdl.handle.net/11449/10760 |
Resumo: | We aimed to compare the analgesic efficacy of the caudal administration of a combination of preservative free S-ketamine or clonidine with bupivacaine in children. The study included 51 children aged between 3 and 8 years old and physical status between I and II according to: American Society of Anesthesiologist. They were randomly divided into three groups: Group B - bupivacaine 0.25%, 0.75 ml/kg without adrenaline; Group C - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and clonidine 1 mu g/kg and; Group K - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and S-ketamine 0.5 mg/kg without conservative. In this study, medication was not used before anesthesia. The evaluation of postoperative analgesia was accomplished through the pain scale of Ouch, the motor blockade assessed by modified Bromage scale and the level of sedation through the three-point scale. The combination of caudal S-ketamine and clonidine with bupivacaine prolonged the duration of postoperative analgesia (p < 0.05) compared to bupivacaine alone. Regarding hemodynamic parameters, bupivacaine associated with clonidine (C) and bupivacaine associated with S-ketamine (K) groups presented diastolic blood pressure changes in the postoperative period. Respiratory rate, regardless of group, showed significant differences over time (p < 0.05). The studied groups showed non significant changes in the degree of motor blockade and sedation score and we observed no clinical significant side effects. S-ketamine and clonidine associated with bupivacaine prolongs postoperative analgesia without clinically significant side effects. |
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Comparison between S-ketamine and clonidine in caudal analgesiaPediatric assistantsanesthesiaanalgesiaepiduralanesthesiacaudalanestheticsWe aimed to compare the analgesic efficacy of the caudal administration of a combination of preservative free S-ketamine or clonidine with bupivacaine in children. The study included 51 children aged between 3 and 8 years old and physical status between I and II according to: American Society of Anesthesiologist. They were randomly divided into three groups: Group B - bupivacaine 0.25%, 0.75 ml/kg without adrenaline; Group C - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and clonidine 1 mu g/kg and; Group K - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and S-ketamine 0.5 mg/kg without conservative. In this study, medication was not used before anesthesia. The evaluation of postoperative analgesia was accomplished through the pain scale of Ouch, the motor blockade assessed by modified Bromage scale and the level of sedation through the three-point scale. The combination of caudal S-ketamine and clonidine with bupivacaine prolonged the duration of postoperative analgesia (p < 0.05) compared to bupivacaine alone. Regarding hemodynamic parameters, bupivacaine associated with clonidine (C) and bupivacaine associated with S-ketamine (K) groups presented diastolic blood pressure changes in the postoperative period. Respiratory rate, regardless of group, showed significant differences over time (p < 0.05). The studied groups showed non significant changes in the degree of motor blockade and sedation score and we observed no clinical significant side effects. S-ketamine and clonidine associated with bupivacaine prolongs postoperative analgesia without clinically significant side effects.Nucleo de Estudos, Pesquisas e Assessoria a Saúde da Faculdade de Medicina do ABC (NEPAS-FMABC)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fac Med ABC, Disciplina Anestesiol, Santo Andre, SP, BrazilFac Med ABC, Dept Morfol & Fisiol, Santo Andre, SP, BrazilUniv Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, BrazilDisciplina Saúde Colet, Santo Candre, SP, BrazilFac Med ABC, Santo Candre, SP, BrazilUniv Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, BrazilAcademic JournalsFac Med ABCUniversidade Estadual Paulista (Unesp)Disciplina Saúde ColetRibeiro, Onesimo D.Abreu, Luiz Carlos de [UNESP]Valenti, Vitor Engrácia [UNESP]Cisternas, Jose RaulSaletti, DeiseLima, Carla J. B.Silvestre, Diego N.Godoy, Ivan R. B.Mello, Luiz G. M.Nascimento, Vania B.Martins, Lourdes C.2014-05-20T13:31:34Z2014-05-20T13:31:34Z2011-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2598-2604application/pdfhttp://dx.doi.org/10.5897/AJPP11.486African Journal of Pharmacy and Pharmacology. Victoria Island: Academic Journals, v. 5, n. 23, p. 2598-2604, 2011.1996-0816http://hdl.handle.net/11449/1076010.5897/AJPP11.486WOS:000299677800010WOS000299677800010.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Pharmacy and Pharmacologyinfo:eu-repo/semantics/openAccess2024-08-09T17:39:45Zoai:repositorio.unesp.br:11449/10760Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-09T17:39:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparison between S-ketamine and clonidine in caudal analgesia |
title |
Comparison between S-ketamine and clonidine in caudal analgesia |
spellingShingle |
Comparison between S-ketamine and clonidine in caudal analgesia Ribeiro, Onesimo D. Pediatric assistants anesthesia analgesia epidural anesthesia caudal anesthetics |
title_short |
Comparison between S-ketamine and clonidine in caudal analgesia |
title_full |
Comparison between S-ketamine and clonidine in caudal analgesia |
title_fullStr |
Comparison between S-ketamine and clonidine in caudal analgesia |
title_full_unstemmed |
Comparison between S-ketamine and clonidine in caudal analgesia |
title_sort |
Comparison between S-ketamine and clonidine in caudal analgesia |
author |
Ribeiro, Onesimo D. |
author_facet |
Ribeiro, Onesimo D. Abreu, Luiz Carlos de [UNESP] Valenti, Vitor Engrácia [UNESP] Cisternas, Jose Raul Saletti, Deise Lima, Carla J. B. Silvestre, Diego N. Godoy, Ivan R. B. Mello, Luiz G. M. Nascimento, Vania B. Martins, Lourdes C. |
author_role |
author |
author2 |
Abreu, Luiz Carlos de [UNESP] Valenti, Vitor Engrácia [UNESP] Cisternas, Jose Raul Saletti, Deise Lima, Carla J. B. Silvestre, Diego N. Godoy, Ivan R. B. Mello, Luiz G. M. Nascimento, Vania B. Martins, Lourdes C. |
author2_role |
author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Fac Med ABC Universidade Estadual Paulista (Unesp) Disciplina Saúde Colet |
dc.contributor.author.fl_str_mv |
Ribeiro, Onesimo D. Abreu, Luiz Carlos de [UNESP] Valenti, Vitor Engrácia [UNESP] Cisternas, Jose Raul Saletti, Deise Lima, Carla J. B. Silvestre, Diego N. Godoy, Ivan R. B. Mello, Luiz G. M. Nascimento, Vania B. Martins, Lourdes C. |
dc.subject.por.fl_str_mv |
Pediatric assistants anesthesia analgesia epidural anesthesia caudal anesthetics |
topic |
Pediatric assistants anesthesia analgesia epidural anesthesia caudal anesthetics |
description |
We aimed to compare the analgesic efficacy of the caudal administration of a combination of preservative free S-ketamine or clonidine with bupivacaine in children. The study included 51 children aged between 3 and 8 years old and physical status between I and II according to: American Society of Anesthesiologist. They were randomly divided into three groups: Group B - bupivacaine 0.25%, 0.75 ml/kg without adrenaline; Group C - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and clonidine 1 mu g/kg and; Group K - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and S-ketamine 0.5 mg/kg without conservative. In this study, medication was not used before anesthesia. The evaluation of postoperative analgesia was accomplished through the pain scale of Ouch, the motor blockade assessed by modified Bromage scale and the level of sedation through the three-point scale. The combination of caudal S-ketamine and clonidine with bupivacaine prolonged the duration of postoperative analgesia (p < 0.05) compared to bupivacaine alone. Regarding hemodynamic parameters, bupivacaine associated with clonidine (C) and bupivacaine associated with S-ketamine (K) groups presented diastolic blood pressure changes in the postoperative period. Respiratory rate, regardless of group, showed significant differences over time (p < 0.05). The studied groups showed non significant changes in the degree of motor blockade and sedation score and we observed no clinical significant side effects. S-ketamine and clonidine associated with bupivacaine prolongs postoperative analgesia without clinically significant side effects. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 2014-05-20T13:31:34Z 2014-05-20T13:31:34Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.5897/AJPP11.486 African Journal of Pharmacy and Pharmacology. Victoria Island: Academic Journals, v. 5, n. 23, p. 2598-2604, 2011. 1996-0816 http://hdl.handle.net/11449/10760 10.5897/AJPP11.486 WOS:000299677800010 WOS000299677800010.pdf |
url |
http://dx.doi.org/10.5897/AJPP11.486 http://hdl.handle.net/11449/10760 |
identifier_str_mv |
African Journal of Pharmacy and Pharmacology. Victoria Island: Academic Journals, v. 5, n. 23, p. 2598-2604, 2011. 1996-0816 10.5897/AJPP11.486 WOS:000299677800010 WOS000299677800010.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
African Journal of Pharmacy and Pharmacology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
2598-2604 application/pdf |
dc.publisher.none.fl_str_mv |
Academic Journals |
publisher.none.fl_str_mv |
Academic Journals |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
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1808128179039109120 |