Comparison between S-ketamine and clonidine in caudal analgesia

Detalhes bibliográficos
Autor(a) principal: Ribeiro, Onesimo D.
Data de Publicação: 2011
Outros Autores: Abreu, Luiz Carlos de [UNESP], Valenti, Vitor Engrácia [UNESP], Cisternas, Jose Raul, Saletti, Deise, Lima, Carla J. B., Silvestre, Diego N., Godoy, Ivan R. B., Mello, Luiz G. M., Nascimento, Vania B., Martins, Lourdes C.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.5897/AJPP11.486
http://hdl.handle.net/11449/10760
Resumo: We aimed to compare the analgesic efficacy of the caudal administration of a combination of preservative free S-ketamine or clonidine with bupivacaine in children. The study included 51 children aged between 3 and 8 years old and physical status between I and II according to: American Society of Anesthesiologist. They were randomly divided into three groups: Group B - bupivacaine 0.25%, 0.75 ml/kg without adrenaline; Group C - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and clonidine 1 mu g/kg and; Group K - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and S-ketamine 0.5 mg/kg without conservative. In this study, medication was not used before anesthesia. The evaluation of postoperative analgesia was accomplished through the pain scale of Ouch, the motor blockade assessed by modified Bromage scale and the level of sedation through the three-point scale. The combination of caudal S-ketamine and clonidine with bupivacaine prolonged the duration of postoperative analgesia (p < 0.05) compared to bupivacaine alone. Regarding hemodynamic parameters, bupivacaine associated with clonidine (C) and bupivacaine associated with S-ketamine (K) groups presented diastolic blood pressure changes in the postoperative period. Respiratory rate, regardless of group, showed significant differences over time (p < 0.05). The studied groups showed non significant changes in the degree of motor blockade and sedation score and we observed no clinical significant side effects. S-ketamine and clonidine associated with bupivacaine prolongs postoperative analgesia without clinically significant side effects.
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spelling Comparison between S-ketamine and clonidine in caudal analgesiaPediatric assistantsanesthesiaanalgesiaepiduralanesthesiacaudalanestheticsWe aimed to compare the analgesic efficacy of the caudal administration of a combination of preservative free S-ketamine or clonidine with bupivacaine in children. The study included 51 children aged between 3 and 8 years old and physical status between I and II according to: American Society of Anesthesiologist. They were randomly divided into three groups: Group B - bupivacaine 0.25%, 0.75 ml/kg without adrenaline; Group C - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and clonidine 1 mu g/kg and; Group K - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and S-ketamine 0.5 mg/kg without conservative. In this study, medication was not used before anesthesia. The evaluation of postoperative analgesia was accomplished through the pain scale of Ouch, the motor blockade assessed by modified Bromage scale and the level of sedation through the three-point scale. The combination of caudal S-ketamine and clonidine with bupivacaine prolonged the duration of postoperative analgesia (p < 0.05) compared to bupivacaine alone. Regarding hemodynamic parameters, bupivacaine associated with clonidine (C) and bupivacaine associated with S-ketamine (K) groups presented diastolic blood pressure changes in the postoperative period. Respiratory rate, regardless of group, showed significant differences over time (p < 0.05). The studied groups showed non significant changes in the degree of motor blockade and sedation score and we observed no clinical significant side effects. S-ketamine and clonidine associated with bupivacaine prolongs postoperative analgesia without clinically significant side effects.Nucleo de Estudos, Pesquisas e Assessoria a Saúde da Faculdade de Medicina do ABC (NEPAS-FMABC)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fac Med ABC, Disciplina Anestesiol, Santo Andre, SP, BrazilFac Med ABC, Dept Morfol & Fisiol, Santo Andre, SP, BrazilUniv Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, BrazilDisciplina Saúde Colet, Santo Candre, SP, BrazilFac Med ABC, Santo Candre, SP, BrazilUniv Estadual Paulista, Fac Filosofia & Ciencias, Dept Fonoaudiol, Marilia, SP, BrazilAcademic JournalsFac Med ABCUniversidade Estadual Paulista (Unesp)Disciplina Saúde ColetRibeiro, Onesimo D.Abreu, Luiz Carlos de [UNESP]Valenti, Vitor Engrácia [UNESP]Cisternas, Jose RaulSaletti, DeiseLima, Carla J. B.Silvestre, Diego N.Godoy, Ivan R. B.Mello, Luiz G. M.Nascimento, Vania B.Martins, Lourdes C.2014-05-20T13:31:34Z2014-05-20T13:31:34Z2011-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article2598-2604application/pdfhttp://dx.doi.org/10.5897/AJPP11.486African Journal of Pharmacy and Pharmacology. Victoria Island: Academic Journals, v. 5, n. 23, p. 2598-2604, 2011.1996-0816http://hdl.handle.net/11449/1076010.5897/AJPP11.486WOS:000299677800010WOS000299677800010.pdfWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAfrican Journal of Pharmacy and Pharmacologyinfo:eu-repo/semantics/openAccess2024-08-09T17:39:45Zoai:repositorio.unesp.br:11449/10760Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-09T17:39:45Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Comparison between S-ketamine and clonidine in caudal analgesia
title Comparison between S-ketamine and clonidine in caudal analgesia
spellingShingle Comparison between S-ketamine and clonidine in caudal analgesia
Ribeiro, Onesimo D.
Pediatric assistants
anesthesia
analgesia
epidural
anesthesia
caudal
anesthetics
title_short Comparison between S-ketamine and clonidine in caudal analgesia
title_full Comparison between S-ketamine and clonidine in caudal analgesia
title_fullStr Comparison between S-ketamine and clonidine in caudal analgesia
title_full_unstemmed Comparison between S-ketamine and clonidine in caudal analgesia
title_sort Comparison between S-ketamine and clonidine in caudal analgesia
author Ribeiro, Onesimo D.
author_facet Ribeiro, Onesimo D.
Abreu, Luiz Carlos de [UNESP]
Valenti, Vitor Engrácia [UNESP]
Cisternas, Jose Raul
Saletti, Deise
Lima, Carla J. B.
Silvestre, Diego N.
Godoy, Ivan R. B.
Mello, Luiz G. M.
Nascimento, Vania B.
Martins, Lourdes C.
author_role author
author2 Abreu, Luiz Carlos de [UNESP]
Valenti, Vitor Engrácia [UNESP]
Cisternas, Jose Raul
Saletti, Deise
Lima, Carla J. B.
Silvestre, Diego N.
Godoy, Ivan R. B.
Mello, Luiz G. M.
Nascimento, Vania B.
Martins, Lourdes C.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Fac Med ABC
Universidade Estadual Paulista (Unesp)
Disciplina Saúde Colet
dc.contributor.author.fl_str_mv Ribeiro, Onesimo D.
Abreu, Luiz Carlos de [UNESP]
Valenti, Vitor Engrácia [UNESP]
Cisternas, Jose Raul
Saletti, Deise
Lima, Carla J. B.
Silvestre, Diego N.
Godoy, Ivan R. B.
Mello, Luiz G. M.
Nascimento, Vania B.
Martins, Lourdes C.
dc.subject.por.fl_str_mv Pediatric assistants
anesthesia
analgesia
epidural
anesthesia
caudal
anesthetics
topic Pediatric assistants
anesthesia
analgesia
epidural
anesthesia
caudal
anesthetics
description We aimed to compare the analgesic efficacy of the caudal administration of a combination of preservative free S-ketamine or clonidine with bupivacaine in children. The study included 51 children aged between 3 and 8 years old and physical status between I and II according to: American Society of Anesthesiologist. They were randomly divided into three groups: Group B - bupivacaine 0.25%, 0.75 ml/kg without adrenaline; Group C - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and clonidine 1 mu g/kg and; Group K - bupivacaine 0.25%, 0.75 ml/kg without adrenaline and S-ketamine 0.5 mg/kg without conservative. In this study, medication was not used before anesthesia. The evaluation of postoperative analgesia was accomplished through the pain scale of Ouch, the motor blockade assessed by modified Bromage scale and the level of sedation through the three-point scale. The combination of caudal S-ketamine and clonidine with bupivacaine prolonged the duration of postoperative analgesia (p < 0.05) compared to bupivacaine alone. Regarding hemodynamic parameters, bupivacaine associated with clonidine (C) and bupivacaine associated with S-ketamine (K) groups presented diastolic blood pressure changes in the postoperative period. Respiratory rate, regardless of group, showed significant differences over time (p < 0.05). The studied groups showed non significant changes in the degree of motor blockade and sedation score and we observed no clinical significant side effects. S-ketamine and clonidine associated with bupivacaine prolongs postoperative analgesia without clinically significant side effects.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
2014-05-20T13:31:34Z
2014-05-20T13:31:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.5897/AJPP11.486
African Journal of Pharmacy and Pharmacology. Victoria Island: Academic Journals, v. 5, n. 23, p. 2598-2604, 2011.
1996-0816
http://hdl.handle.net/11449/10760
10.5897/AJPP11.486
WOS:000299677800010
WOS000299677800010.pdf
url http://dx.doi.org/10.5897/AJPP11.486
http://hdl.handle.net/11449/10760
identifier_str_mv African Journal of Pharmacy and Pharmacology. Victoria Island: Academic Journals, v. 5, n. 23, p. 2598-2604, 2011.
1996-0816
10.5897/AJPP11.486
WOS:000299677800010
WOS000299677800010.pdf
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv African Journal of Pharmacy and Pharmacology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 2598-2604
application/pdf
dc.publisher.none.fl_str_mv Academic Journals
publisher.none.fl_str_mv Academic Journals
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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