Morphologic changes in the vesical transition epithelium of alcoholic rats
Autor(a) principal: | |
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Data de Publicação: | 1997 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://hdl.handle.net/11449/224060 |
Resumo: | Few studies are available about the effect of alcohol on the epithelium of the urinary bladder. In the present investigation we studied the ultrastructure of the vesical transition epithelium of normal rats and of rats submitted to experimental chronic alcoholism. Adult rats were submitted to experimental chronic alcoholism by the ingestion of sugar cane liquor. The vesical epithelium was examined after 60, 120, 180 and 240 days of alcohol treatment by transmission electron microscopy. Surface cells presented nuclear and cytoplasmic changes and marked cellular desquamation. There was an increase in multivesicular bodies and lysosomes suggesting cell degeneration. Mast cell infiltration was observed, possibly related to increased epithelial sensitivity. Intercellular spaces were frequently observed. The transition epithelium of the urinary bladder was found to be sensitive to the action of alcohol, as demonstrated by the changes in the components of the blood-urine barrier, the greater sensitivity to inflammation, the increase in cell desquamation and the greater recycling of the apical membrane and of the fusiform vesicles of surface cells observed in alcoholic rats. |
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Morphologic changes in the vesical transition epithelium of alcoholic ratsAlcoholismElectron microscopyEpithelium urinary bladderRatFew studies are available about the effect of alcohol on the epithelium of the urinary bladder. In the present investigation we studied the ultrastructure of the vesical transition epithelium of normal rats and of rats submitted to experimental chronic alcoholism. Adult rats were submitted to experimental chronic alcoholism by the ingestion of sugar cane liquor. The vesical epithelium was examined after 60, 120, 180 and 240 days of alcohol treatment by transmission electron microscopy. Surface cells presented nuclear and cytoplasmic changes and marked cellular desquamation. There was an increase in multivesicular bodies and lysosomes suggesting cell degeneration. Mast cell infiltration was observed, possibly related to increased epithelial sensitivity. Intercellular spaces were frequently observed. The transition epithelium of the urinary bladder was found to be sensitive to the action of alcohol, as demonstrated by the changes in the components of the blood-urine barrier, the greater sensitivity to inflammation, the increase in cell desquamation and the greater recycling of the apical membrane and of the fusiform vesicles of surface cells observed in alcoholic rats.Department of Anatomy Institute of Biosciences São Paulo State University, Botucatu, SPDepartamento de Anatomia Instituto de Biociências UNESP, 18618-000 Botucatu SPDepartment of Anatomy Institute of Biosciences São Paulo State University, Botucatu, SPDepartamento de Anatomia Instituto de Biociências UNESP, 18618-000 Botucatu SPUniversidade Estadual Paulista (UNESP)Mello, W. [UNESP]Garcia, P. J. [UNESP]Cagnon, V. H.A.Martinez, M. [UNESP]Martinez, F. E. [UNESP]2022-04-28T19:54:29Z2022-04-28T19:54:29Z1997-07-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article393-399Journal of Submicroscopic Cytology and Pathology, v. 29, n. 3, p. 393-399, 1997.1122-9497http://hdl.handle.net/11449/2240602-s2.0-0031183820Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Submicroscopic Cytology and Pathologyinfo:eu-repo/semantics/openAccess2022-04-28T19:54:29Zoai:repositorio.unesp.br:11449/224060Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T21:55:36.725498Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Morphologic changes in the vesical transition epithelium of alcoholic rats |
title |
Morphologic changes in the vesical transition epithelium of alcoholic rats |
spellingShingle |
Morphologic changes in the vesical transition epithelium of alcoholic rats Mello, W. [UNESP] Alcoholism Electron microscopy Epithelium urinary bladder Rat |
title_short |
Morphologic changes in the vesical transition epithelium of alcoholic rats |
title_full |
Morphologic changes in the vesical transition epithelium of alcoholic rats |
title_fullStr |
Morphologic changes in the vesical transition epithelium of alcoholic rats |
title_full_unstemmed |
Morphologic changes in the vesical transition epithelium of alcoholic rats |
title_sort |
Morphologic changes in the vesical transition epithelium of alcoholic rats |
author |
Mello, W. [UNESP] |
author_facet |
Mello, W. [UNESP] Garcia, P. J. [UNESP] Cagnon, V. H.A. Martinez, M. [UNESP] Martinez, F. E. [UNESP] |
author_role |
author |
author2 |
Garcia, P. J. [UNESP] Cagnon, V. H.A. Martinez, M. [UNESP] Martinez, F. E. [UNESP] |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Mello, W. [UNESP] Garcia, P. J. [UNESP] Cagnon, V. H.A. Martinez, M. [UNESP] Martinez, F. E. [UNESP] |
dc.subject.por.fl_str_mv |
Alcoholism Electron microscopy Epithelium urinary bladder Rat |
topic |
Alcoholism Electron microscopy Epithelium urinary bladder Rat |
description |
Few studies are available about the effect of alcohol on the epithelium of the urinary bladder. In the present investigation we studied the ultrastructure of the vesical transition epithelium of normal rats and of rats submitted to experimental chronic alcoholism. Adult rats were submitted to experimental chronic alcoholism by the ingestion of sugar cane liquor. The vesical epithelium was examined after 60, 120, 180 and 240 days of alcohol treatment by transmission electron microscopy. Surface cells presented nuclear and cytoplasmic changes and marked cellular desquamation. There was an increase in multivesicular bodies and lysosomes suggesting cell degeneration. Mast cell infiltration was observed, possibly related to increased epithelial sensitivity. Intercellular spaces were frequently observed. The transition epithelium of the urinary bladder was found to be sensitive to the action of alcohol, as demonstrated by the changes in the components of the blood-urine barrier, the greater sensitivity to inflammation, the increase in cell desquamation and the greater recycling of the apical membrane and of the fusiform vesicles of surface cells observed in alcoholic rats. |
publishDate |
1997 |
dc.date.none.fl_str_mv |
1997-07-01 2022-04-28T19:54:29Z 2022-04-28T19:54:29Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
Journal of Submicroscopic Cytology and Pathology, v. 29, n. 3, p. 393-399, 1997. 1122-9497 http://hdl.handle.net/11449/224060 2-s2.0-0031183820 |
identifier_str_mv |
Journal of Submicroscopic Cytology and Pathology, v. 29, n. 3, p. 393-399, 1997. 1122-9497 2-s2.0-0031183820 |
url |
http://hdl.handle.net/11449/224060 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Submicroscopic Cytology and Pathology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
393-399 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808129374289920000 |