Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface

Detalhes bibliográficos
Autor(a) principal: Corzo, Sandra P.
Data de Publicação: 2021
Outros Autores: Bueno, Paulo R. [UNESP], Miranda, David A.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
DOI: 10.1109/ACCESS.2021.3135787
Texto Completo: http://dx.doi.org/10.1109/ACCESS.2021.3135787
http://hdl.handle.net/11449/233937
Resumo: Miranda and Bueno recently demonstrated that chemical hardness could be experimentally measured and used as a chemical reactivity index of electrochemical interfaces. Herein, we applied this reactivity index concept to sense biological targets of medical interest, demonstrating the advantages of using this concept in improving the reproducibility of signal analysis during the construction of analytical curves. An analytical signal was obtained for sensing based on the effective chemical hardness of the quantum capacitive electroactive moieties of the interface, demonstrating advantages for calibration compared with methods based solely on the inverse of capacitance. The clinical value of this concept was demonstrated by studying the biological interaction of paclitaxel withβ -tubulin.
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spelling Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the InterfaceAnalytical curveCalibration procedureConceptual density functional theoryElectrochemical sensorQuality control and reproducibilityQuantum capacitanceMiranda and Bueno recently demonstrated that chemical hardness could be experimentally measured and used as a chemical reactivity index of electrochemical interfaces. Herein, we applied this reactivity index concept to sense biological targets of medical interest, demonstrating the advantages of using this concept in improving the reproducibility of signal analysis during the construction of analytical curves. An analytical signal was obtained for sensing based on the effective chemical hardness of the quantum capacitive electroactive moieties of the interface, demonstrating advantages for calibration compared with methods based solely on the inverse of capacitance. The clinical value of this concept was demonstrated by studying the biological interaction of paclitaxel withβ -tubulin.Escuela de Física Universidad Industrial de SantanderDepartment of Engineering Physics and Mathematics Universidade Estadual Paulista (UNESP), AraraquaraDepartment of Engineering Physics and Mathematics Universidade Estadual Paulista (UNESP), AraraquaraUniversidad Industrial de SantanderUniversidade Estadual Paulista (UNESP)Corzo, Sandra P.Bueno, Paulo R. [UNESP]Miranda, David A.2022-05-01T11:54:06Z2022-05-01T11:54:06Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article166446-166454http://dx.doi.org/10.1109/ACCESS.2021.3135787IEEE Access, v. 9, p. 166446-166454.2169-3536http://hdl.handle.net/11449/23393710.1109/ACCESS.2021.31357872-s2.0-85121795320Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengIEEE Accessinfo:eu-repo/semantics/openAccess2022-05-01T11:54:06Zoai:repositorio.unesp.br:11449/233937Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T18:56:59.314271Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
title Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
spellingShingle Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
Corzo, Sandra P.
Analytical curve
Calibration procedure
Conceptual density functional theory
Electrochemical sensor
Quality control and reproducibility
Quantum capacitance
Corzo, Sandra P.
Analytical curve
Calibration procedure
Conceptual density functional theory
Electrochemical sensor
Quality control and reproducibility
Quantum capacitance
title_short Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
title_full Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
title_fullStr Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
title_full_unstemmed Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
title_sort Improving the Analytical Reproducibility of Electrochemical Capacitive Sensors Using the Chemical Hardness of the Interface
author Corzo, Sandra P.
author_facet Corzo, Sandra P.
Corzo, Sandra P.
Bueno, Paulo R. [UNESP]
Miranda, David A.
Bueno, Paulo R. [UNESP]
Miranda, David A.
author_role author
author2 Bueno, Paulo R. [UNESP]
Miranda, David A.
author2_role author
author
dc.contributor.none.fl_str_mv Universidad Industrial de Santander
Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Corzo, Sandra P.
Bueno, Paulo R. [UNESP]
Miranda, David A.
dc.subject.por.fl_str_mv Analytical curve
Calibration procedure
Conceptual density functional theory
Electrochemical sensor
Quality control and reproducibility
Quantum capacitance
topic Analytical curve
Calibration procedure
Conceptual density functional theory
Electrochemical sensor
Quality control and reproducibility
Quantum capacitance
description Miranda and Bueno recently demonstrated that chemical hardness could be experimentally measured and used as a chemical reactivity index of electrochemical interfaces. Herein, we applied this reactivity index concept to sense biological targets of medical interest, demonstrating the advantages of using this concept in improving the reproducibility of signal analysis during the construction of analytical curves. An analytical signal was obtained for sensing based on the effective chemical hardness of the quantum capacitive electroactive moieties of the interface, demonstrating advantages for calibration compared with methods based solely on the inverse of capacitance. The clinical value of this concept was demonstrated by studying the biological interaction of paclitaxel withβ -tubulin.
publishDate 2021
dc.date.none.fl_str_mv 2021-01-01
2022-05-01T11:54:06Z
2022-05-01T11:54:06Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1109/ACCESS.2021.3135787
IEEE Access, v. 9, p. 166446-166454.
2169-3536
http://hdl.handle.net/11449/233937
10.1109/ACCESS.2021.3135787
2-s2.0-85121795320
url http://dx.doi.org/10.1109/ACCESS.2021.3135787
http://hdl.handle.net/11449/233937
identifier_str_mv IEEE Access, v. 9, p. 166446-166454.
2169-3536
10.1109/ACCESS.2021.3135787
2-s2.0-85121795320
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv IEEE Access
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 166446-166454
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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dc.identifier.doi.none.fl_str_mv 10.1109/ACCESS.2021.3135787