Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1080/15287394.2020.1786483 http://hdl.handle.net/11449/201939 |
Resumo: | Ibuprofen is one of the most commonly prescribed anti-inflammatory drugs in pediatric practice. This drug inhibits the cyclooxygenase enzyme, reducing the production of prostaglandin, an important mediator on male reproductive function. We examined if pre-pubertal treatment with ibuprofen in male rats can affect the reproductive parameters of these animals in adult life and on their descendants. Male rats (23 days old) received ibuprofen (0; 2.4; 7.2 or 14.3 mg/kg/day), per gavage, from postnatal day (PND) 23 to 53. At sexual maturity, treated males were placed with untreated females for obtaining the next generation (F1). The highest dose of ibuprofen interfered in sexual behavior and reduced the fertility potential of these animals in adulthood. Additionally, the ibuprofen treatment altered the sperm quantity and quality, as evidenced by a decrease in sperm motility and in the daily sperm production in the testis. Testosterone levels were also reduced by pre-pubertal treatment. The paternal treatment with this drug also influenced the reproductive outcomes of progeny. The male offspring from males treated exhibited acceleration in sperm transit time in the epididymis and the number and volume of Leydig cell nuclei were decreased, while the estrous cyclicity was displayed and the fertility potential reduced in the female offspring. The pre-pubertal ibuprofen-treatment caused negative reproductive impacts in adulthood, compromising sperm quality and quantity, as well as interfered in the reproductive outcomes of the next generation. |
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Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generationmultigenerational effectsNon-steroidal anti-inflammatoryperipubertyprostaglandinspermIbuprofen is one of the most commonly prescribed anti-inflammatory drugs in pediatric practice. This drug inhibits the cyclooxygenase enzyme, reducing the production of prostaglandin, an important mediator on male reproductive function. We examined if pre-pubertal treatment with ibuprofen in male rats can affect the reproductive parameters of these animals in adult life and on their descendants. Male rats (23 days old) received ibuprofen (0; 2.4; 7.2 or 14.3 mg/kg/day), per gavage, from postnatal day (PND) 23 to 53. At sexual maturity, treated males were placed with untreated females for obtaining the next generation (F1). The highest dose of ibuprofen interfered in sexual behavior and reduced the fertility potential of these animals in adulthood. Additionally, the ibuprofen treatment altered the sperm quantity and quality, as evidenced by a decrease in sperm motility and in the daily sperm production in the testis. Testosterone levels were also reduced by pre-pubertal treatment. The paternal treatment with this drug also influenced the reproductive outcomes of progeny. The male offspring from males treated exhibited acceleration in sperm transit time in the epididymis and the number and volume of Leydig cell nuclei were decreased, while the estrous cyclicity was displayed and the fertility potential reduced in the female offspring. The pre-pubertal ibuprofen-treatment caused negative reproductive impacts in adulthood, compromising sperm quality and quantity, as well as interfered in the reproductive outcomes of the next generation.Department of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)College of Health Science Federal University of Grande Dourados – DouradosDepartment of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University (UNESP)Department of Structural and Functional Biology Institute of Biosciences of Botucatu Univ. Estadual Paulista – Botucatu (UNESP)Department of Structural and Functional Biology Institute of Biosciences of Botucatu São Paulo State University (UNESP)Universidade Estadual Paulista (Unesp)Federal University of Grande Dourados – DouradosBarbosa, Mariana Gazoli [UNESP]Jorge, Bárbara Campos [UNESP]Stein, Julia [UNESP]Santos Ferreira, Dayana Agnes [UNESP]Barreto, Ana Carolina da Silva [UNESP]Reis, Ana Carolina Casali [UNESP]Moreira, Suyane Da Silva [UNESP]Inocencio, Leonardo Cesar De Lima [UNESP]Macorini, Luis Fernando BenitezArena, Arielle Cristina [UNESP]2020-12-12T02:45:47Z2020-12-12T02:45:47Z2020-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-14http://dx.doi.org/10.1080/15287394.2020.1786483Journal of Toxicology and Environmental Health - Part A: Current Issues, p. 1-14.1087-26201528-7394http://hdl.handle.net/11449/20193910.1080/15287394.2020.17864832-s2.0-85087636069Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Toxicology and Environmental Health - Part A: Current Issuesinfo:eu-repo/semantics/openAccess2021-10-23T03:12:50Zoai:repositorio.unesp.br:11449/201939Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T03:12:50Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation |
title |
Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation |
spellingShingle |
Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation Barbosa, Mariana Gazoli [UNESP] multigenerational effects Non-steroidal anti-inflammatory peripuberty prostaglandin sperm |
title_short |
Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation |
title_full |
Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation |
title_fullStr |
Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation |
title_full_unstemmed |
Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation |
title_sort |
Pre-pubertal exposure to ibuprofen impairs sperm parameters in male adult rats and compromises the next generation |
author |
Barbosa, Mariana Gazoli [UNESP] |
author_facet |
Barbosa, Mariana Gazoli [UNESP] Jorge, Bárbara Campos [UNESP] Stein, Julia [UNESP] Santos Ferreira, Dayana Agnes [UNESP] Barreto, Ana Carolina da Silva [UNESP] Reis, Ana Carolina Casali [UNESP] Moreira, Suyane Da Silva [UNESP] Inocencio, Leonardo Cesar De Lima [UNESP] Macorini, Luis Fernando Benitez Arena, Arielle Cristina [UNESP] |
author_role |
author |
author2 |
Jorge, Bárbara Campos [UNESP] Stein, Julia [UNESP] Santos Ferreira, Dayana Agnes [UNESP] Barreto, Ana Carolina da Silva [UNESP] Reis, Ana Carolina Casali [UNESP] Moreira, Suyane Da Silva [UNESP] Inocencio, Leonardo Cesar De Lima [UNESP] Macorini, Luis Fernando Benitez Arena, Arielle Cristina [UNESP] |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Federal University of Grande Dourados – Dourados |
dc.contributor.author.fl_str_mv |
Barbosa, Mariana Gazoli [UNESP] Jorge, Bárbara Campos [UNESP] Stein, Julia [UNESP] Santos Ferreira, Dayana Agnes [UNESP] Barreto, Ana Carolina da Silva [UNESP] Reis, Ana Carolina Casali [UNESP] Moreira, Suyane Da Silva [UNESP] Inocencio, Leonardo Cesar De Lima [UNESP] Macorini, Luis Fernando Benitez Arena, Arielle Cristina [UNESP] |
dc.subject.por.fl_str_mv |
multigenerational effects Non-steroidal anti-inflammatory peripuberty prostaglandin sperm |
topic |
multigenerational effects Non-steroidal anti-inflammatory peripuberty prostaglandin sperm |
description |
Ibuprofen is one of the most commonly prescribed anti-inflammatory drugs in pediatric practice. This drug inhibits the cyclooxygenase enzyme, reducing the production of prostaglandin, an important mediator on male reproductive function. We examined if pre-pubertal treatment with ibuprofen in male rats can affect the reproductive parameters of these animals in adult life and on their descendants. Male rats (23 days old) received ibuprofen (0; 2.4; 7.2 or 14.3 mg/kg/day), per gavage, from postnatal day (PND) 23 to 53. At sexual maturity, treated males were placed with untreated females for obtaining the next generation (F1). The highest dose of ibuprofen interfered in sexual behavior and reduced the fertility potential of these animals in adulthood. Additionally, the ibuprofen treatment altered the sperm quantity and quality, as evidenced by a decrease in sperm motility and in the daily sperm production in the testis. Testosterone levels were also reduced by pre-pubertal treatment. The paternal treatment with this drug also influenced the reproductive outcomes of progeny. The male offspring from males treated exhibited acceleration in sperm transit time in the epididymis and the number and volume of Leydig cell nuclei were decreased, while the estrous cyclicity was displayed and the fertility potential reduced in the female offspring. The pre-pubertal ibuprofen-treatment caused negative reproductive impacts in adulthood, compromising sperm quality and quantity, as well as interfered in the reproductive outcomes of the next generation. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-12-12T02:45:47Z 2020-12-12T02:45:47Z 2020-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1080/15287394.2020.1786483 Journal of Toxicology and Environmental Health - Part A: Current Issues, p. 1-14. 1087-2620 1528-7394 http://hdl.handle.net/11449/201939 10.1080/15287394.2020.1786483 2-s2.0-85087636069 |
url |
http://dx.doi.org/10.1080/15287394.2020.1786483 http://hdl.handle.net/11449/201939 |
identifier_str_mv |
Journal of Toxicology and Environmental Health - Part A: Current Issues, p. 1-14. 1087-2620 1528-7394 10.1080/15287394.2020.1786483 2-s2.0-85087636069 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Journal of Toxicology and Environmental Health - Part A: Current Issues |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-14 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797789743111471104 |