Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes

Detalhes bibliográficos
Autor(a) principal: Souza, José António Santos [UNESP]
Data de Publicação: 2020
Outros Autores: Alves, Marta M., Barbosa, Debora Barros [UNESP], Lopes, Maria Manuel, Pinto, Eugénia, Figueiral, Maria Helena, Delbem, Alberto Carlos B [UNESP], Mira, Nuno Pereira
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1093/mmy/myz094
http://hdl.handle.net/11449/200544
Resumo: The continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, amphotericin B or nystatine, to inhibit growth of C. albicans and C. glabrata oral clinical strains, including in strains showing resistance to fluconazole. A potent inhibitory effect over biofilm formation prompted by the two Candida species was also observed, including in mature biofilm cells. These results foster the use of phytotherapeutics as effective treatments in oral candidiasis.
id UNSP_10bde97b05bd182fa3ab9b99196edd7c
oai_identifier_str oai:repositorio.unesp.br:11449/200544
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenesPunica granatumoral candidiasisphytotherapeuticssilver nanoparticles‘green’ synthesisThe continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, amphotericin B or nystatine, to inhibit growth of C. albicans and C. glabrata oral clinical strains, including in strains showing resistance to fluconazole. A potent inhibitory effect over biofilm formation prompted by the two Candida species was also observed, including in mature biofilm cells. These results foster the use of phytotherapeutics as effective treatments in oral candidiasis.São Paulo State University (UNESP) School of Dentistry Araçatuba Department of Pediatric Dentistry and Public HealthCentro de Química Estrutural Instituto Superior Técnico Universidade de LisboaSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Dental Materials and ProsthodonticsFaculdade de Farmácia da Universidade de Lisboa Departamento de Microbiologia e Imunologia, Av. Prof. Gama PintoLaboratory of Microbiology, Biological Sciences Department, Faculty of Pharmacy of University of Porto, Rua de Jorge Viterbo Ferreira, 228, 4050-313 Porto, PortugalInterdisciplinary Centre of Marine and Environmental Research (CIIMAR/CIMAR) University of Porto Terminal de Cruzeiros do Porto de Leixões, Avenida General Norton de MatosFaculty of Dentistry Porto University, Rua Manuel Pereira da SilvaiBB, Institute for Bioengineering and Biosciences, Instituto Superior Técnico - Department of Bioengineering, Universidade de Lisboa, Lisbon, PortugalSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Pediatric Dentistry and Public HealthSão Paulo State University (UNESP) School of Dentistry Araçatuba Department of Dental Materials and ProsthodonticsUniversidade Estadual Paulista (Unesp)Universidade de LisboaFaculdade de Farmácia da Universidade de LisboaTerminal de Cruzeiros do Porto de LeixõesPorto UniversitySouza, José António Santos [UNESP]Alves, Marta M.Barbosa, Debora Barros [UNESP]Lopes, Maria ManuelPinto, EugéniaFigueiral, Maria HelenaDelbem, Alberto Carlos B [UNESP]Mira, Nuno Pereira2020-12-12T02:09:26Z2020-12-12T02:09:26Z2020-06-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article564-567http://dx.doi.org/10.1093/mmy/myz094Medical mycology, v. 58, n. 4, p. 564-567, 2020.1460-2709http://hdl.handle.net/11449/20054410.1093/mmy/myz0942-s2.0-85085714953Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMedical mycologyinfo:eu-repo/semantics/openAccess2024-09-19T17:56:37Zoai:repositorio.unesp.br:11449/200544Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestrepositoriounesp@unesp.bropendoar:29462024-09-19T17:56:37Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes
title Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes
spellingShingle Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes
Souza, José António Santos [UNESP]
Punica granatum
oral candidiasis
phytotherapeutics
silver nanoparticles
‘green’ synthesis
title_short Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes
title_full Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes
title_fullStr Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes
title_full_unstemmed Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes
title_sort Study of the activity of Punica granatum-mediated silver nanoparticles against Candida albicans and Candida glabrata, alone or in combination with azoles or polyenes
author Souza, José António Santos [UNESP]
author_facet Souza, José António Santos [UNESP]
Alves, Marta M.
Barbosa, Debora Barros [UNESP]
Lopes, Maria Manuel
Pinto, Eugénia
Figueiral, Maria Helena
Delbem, Alberto Carlos B [UNESP]
Mira, Nuno Pereira
author_role author
author2 Alves, Marta M.
Barbosa, Debora Barros [UNESP]
Lopes, Maria Manuel
Pinto, Eugénia
Figueiral, Maria Helena
Delbem, Alberto Carlos B [UNESP]
Mira, Nuno Pereira
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (Unesp)
Universidade de Lisboa
Faculdade de Farmácia da Universidade de Lisboa
Terminal de Cruzeiros do Porto de Leixões
Porto University
dc.contributor.author.fl_str_mv Souza, José António Santos [UNESP]
Alves, Marta M.
Barbosa, Debora Barros [UNESP]
Lopes, Maria Manuel
Pinto, Eugénia
Figueiral, Maria Helena
Delbem, Alberto Carlos B [UNESP]
Mira, Nuno Pereira
dc.subject.por.fl_str_mv Punica granatum
oral candidiasis
phytotherapeutics
silver nanoparticles
‘green’ synthesis
topic Punica granatum
oral candidiasis
phytotherapeutics
silver nanoparticles
‘green’ synthesis
description The continuous emergence of Candida strains resistant to currently used antifungals demands the development of new alternatives that could reduce the burden of candidiasis. In this work silver nanoparticles synthesized using a green route are efficiently used, alone or in combination with fluconazole, amphotericin B or nystatine, to inhibit growth of C. albicans and C. glabrata oral clinical strains, including in strains showing resistance to fluconazole. A potent inhibitory effect over biofilm formation prompted by the two Candida species was also observed, including in mature biofilm cells. These results foster the use of phytotherapeutics as effective treatments in oral candidiasis.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-12T02:09:26Z
2020-12-12T02:09:26Z
2020-06-01
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1093/mmy/myz094
Medical mycology, v. 58, n. 4, p. 564-567, 2020.
1460-2709
http://hdl.handle.net/11449/200544
10.1093/mmy/myz094
2-s2.0-85085714953
url http://dx.doi.org/10.1093/mmy/myz094
http://hdl.handle.net/11449/200544
identifier_str_mv Medical mycology, v. 58, n. 4, p. 564-567, 2020.
1460-2709
10.1093/mmy/myz094
2-s2.0-85085714953
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Medical mycology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 564-567
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv repositoriounesp@unesp.br
_version_ 1813546443553636352

Registros relacionados