Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni
Autor(a) principal: | |
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Data de Publicação: | 2007 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/332 http://hdl.handle.net/11449/70140 |
Resumo: | Mansonian schistosomiasis is caused by an intravascular digenetic trematode Schistosoma mansoni. Praziquantel (PZQ) and oxamniquine (OXA) are the drugs of choice for the treatment of this disease. However, both drugs are subject to some limitations in their action and cases of tolerance and resistance have been reported. Moreover, tolerance and resistance cases have been reported. For this reason, there is an urgent need for research on new alternatives aimed at improving the action of existing drugs, such as the incorporation of these drugs into liposomes. In this study, the efficiency of action of liposome- encapsulated praziquantel (lip.PZQ) on oviposition by S. mansoni, strain BH, was assessed in Mus musculus mices (SPF Swiss mice). Four PZQ and lip.PZQ doses (47; 60; 250 e 300mg/kg) were tested. Some mice were treated 30 days post-infection and others after 45 days. The oogram analyses showed that the most effective lip.PZQ treatment was 300mg/kg dose given on the 45th day post infection, which reduced the number of S. mansoni eggs per gram of tissue. |
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Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoniEffect of praziquantel in liposomes on Schistosoma mansoni eggs at different development stagesLiposomeOogramPraziquantelSchistosoma mansoniliposomepraziquantelanimal experimentanimal tissueantiprotozoal activityclinical researchcontrolled studydevelopmental stagedrug coatingegg layingexperimental infectionmousemouse strainnonhumanschistosomiasistherapy effecttreatment outcometreatment responseMansonian schistosomiasis is caused by an intravascular digenetic trematode Schistosoma mansoni. Praziquantel (PZQ) and oxamniquine (OXA) are the drugs of choice for the treatment of this disease. However, both drugs are subject to some limitations in their action and cases of tolerance and resistance have been reported. Moreover, tolerance and resistance cases have been reported. For this reason, there is an urgent need for research on new alternatives aimed at improving the action of existing drugs, such as the incorporation of these drugs into liposomes. In this study, the efficiency of action of liposome- encapsulated praziquantel (lip.PZQ) on oviposition by S. mansoni, strain BH, was assessed in Mus musculus mices (SPF Swiss mice). Four PZQ and lip.PZQ doses (47; 60; 250 e 300mg/kg) were tested. Some mice were treated 30 days post-infection and others after 45 days. The oogram analyses showed that the most effective lip.PZQ treatment was 300mg/kg dose given on the 45th day post infection, which reduced the number of S. mansoni eggs per gram of tissue.A esquistossomose mansônica é causada pelo trematódeo digenético intravascular Schistosoma mansoni. Para o tratamento dessa enfermidade o praziquantel (PZQ) e a oxamniquina (OXA) são os fármacos escolhidos. No entanto, esses fármacos apresentam limitações quanto à ação e casos de resistência ou tolerância já foram relatados. Por esse motivo, são necessários os estudos de novas alternativas que visam melhorar os fármacos já existentes, como a incorporação desses em lipossomas. Este estudo verificou a ação do praziquantel incorporado a lipossomas (lip.PZQ) sobre os ovos de S. mansoni, linhagem BH em camundongos Mus musculus (Swiss- SPF). Para tanto, foram testadas quatro doses de PZQ e lip.PZQ (47; 60; 250 e 300mg/kg) sendo que parte dos camundongos foi tratada após 30 dias de infecção e outra após 45 dias. A análise do oograma mostrou que a dose lip.PZQ 300mg/kg administrada no 45º dia de infecção foi mais eficaz, pois reduziu a oviposição pelas fêmeas de S. mansoni.Departamento de Parasitologia Instituto de Biologie Universidade de Campinas, UNICAMP, Campinas, SPDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, UNESP, Araraquara, SPDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, UNESP, Araraquara, SPDepartamento de Parasitologia Instituto de Biologia Cidade Universitária Zeferino Vaz, s/n, Caixa Postal 6109, CEP: 13083-970 - Campinas - SPDepartamento de Ciências Biológicas Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, UNESP, Araraquara, SPDepartamento de Fármacos e Medicamentos Faculdade de Ciências Farmacêuticas Universidade Estadual Paulista, UNESP, Araraquara, SPUniversidade Estadual de Campinas (UNICAMP)Universidade Estadual Paulista (Unesp)Frezza, T. F.Madi, R. R.Banin, T. M.Pinto, Mara Cristina [UNESP]Souza, A. L. R. [UNESP]Gremião, Maria Palmira Daflon [UNESP]Allegretti, Silmara Marques2014-05-27T11:22:43Z2014-05-27T11:22:43Z2007-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article209-214application/pdfhttp://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/332Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 2, p. 209-214, 2007.1808-4532http://hdl.handle.net/11449/701402-s2.0-413491057462-s2.0-41349105746.pdf82217374915984159129780536724256Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPporRevista de Ciências Farmacêuticas Básica e Aplicada0,131info:eu-repo/semantics/openAccess2024-06-24T13:46:01Zoai:repositorio.unesp.br:11449/70140Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T20:14:52.426805Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni Effect of praziquantel in liposomes on Schistosoma mansoni eggs at different development stages |
title |
Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni |
spellingShingle |
Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni Frezza, T. F. Liposome Oogram Praziquantel Schistosoma mansoni liposome praziquantel animal experiment animal tissue antiprotozoal activity clinical research controlled study developmental stage drug coating egg laying experimental infection mouse mouse strain nonhuman schistosomiasis therapy effect treatment outcome treatment response |
title_short |
Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni |
title_full |
Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni |
title_fullStr |
Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni |
title_full_unstemmed |
Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni |
title_sort |
Efeito do praziquantel incorporado a lipossomas nos diferentes estágios de desenvolvimento dos ovos de Schistosoma mansoni |
author |
Frezza, T. F. |
author_facet |
Frezza, T. F. Madi, R. R. Banin, T. M. Pinto, Mara Cristina [UNESP] Souza, A. L. R. [UNESP] Gremião, Maria Palmira Daflon [UNESP] Allegretti, Silmara Marques |
author_role |
author |
author2 |
Madi, R. R. Banin, T. M. Pinto, Mara Cristina [UNESP] Souza, A. L. R. [UNESP] Gremião, Maria Palmira Daflon [UNESP] Allegretti, Silmara Marques |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual de Campinas (UNICAMP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Frezza, T. F. Madi, R. R. Banin, T. M. Pinto, Mara Cristina [UNESP] Souza, A. L. R. [UNESP] Gremião, Maria Palmira Daflon [UNESP] Allegretti, Silmara Marques |
dc.subject.por.fl_str_mv |
Liposome Oogram Praziquantel Schistosoma mansoni liposome praziquantel animal experiment animal tissue antiprotozoal activity clinical research controlled study developmental stage drug coating egg laying experimental infection mouse mouse strain nonhuman schistosomiasis therapy effect treatment outcome treatment response |
topic |
Liposome Oogram Praziquantel Schistosoma mansoni liposome praziquantel animal experiment animal tissue antiprotozoal activity clinical research controlled study developmental stage drug coating egg laying experimental infection mouse mouse strain nonhuman schistosomiasis therapy effect treatment outcome treatment response |
description |
Mansonian schistosomiasis is caused by an intravascular digenetic trematode Schistosoma mansoni. Praziquantel (PZQ) and oxamniquine (OXA) are the drugs of choice for the treatment of this disease. However, both drugs are subject to some limitations in their action and cases of tolerance and resistance have been reported. Moreover, tolerance and resistance cases have been reported. For this reason, there is an urgent need for research on new alternatives aimed at improving the action of existing drugs, such as the incorporation of these drugs into liposomes. In this study, the efficiency of action of liposome- encapsulated praziquantel (lip.PZQ) on oviposition by S. mansoni, strain BH, was assessed in Mus musculus mices (SPF Swiss mice). Four PZQ and lip.PZQ doses (47; 60; 250 e 300mg/kg) were tested. Some mice were treated 30 days post-infection and others after 45 days. The oogram analyses showed that the most effective lip.PZQ treatment was 300mg/kg dose given on the 45th day post infection, which reduced the number of S. mansoni eggs per gram of tissue. |
publishDate |
2007 |
dc.date.none.fl_str_mv |
2007-12-01 2014-05-27T11:22:43Z 2014-05-27T11:22:43Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/332 Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 2, p. 209-214, 2007. 1808-4532 http://hdl.handle.net/11449/70140 2-s2.0-41349105746 2-s2.0-41349105746.pdf 8221737491598415 9129780536724256 |
url |
http://serv-bib.fcfar.unesp.br/seer/index.php/Cien_Farm/article/view/332 http://hdl.handle.net/11449/70140 |
identifier_str_mv |
Revista de Ciencias Farmaceuticas Basica e Aplicada, v. 28, n. 2, p. 209-214, 2007. 1808-4532 2-s2.0-41349105746 2-s2.0-41349105746.pdf 8221737491598415 9129780536724256 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
Revista de Ciências Farmacêuticas Básica e Aplicada 0,131 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
209-214 application/pdf |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
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1808129179406827520 |