Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy

Detalhes bibliográficos
Autor(a) principal: Okoshi, Katashi [UNESP]
Data de Publicação: 2004
Outros Autores: Ribeiro, Henrique Barbosa [UNESP], Okoshi, Marina Politi [UNESP], Matsubara, Beatriz Bojikian [UNESP], Gonçalves, Giancarlo [UNESP], Barros, Reginaldo [UNESP], Cicogna, Antonio Carlos [UNESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1536/jhj.45.647
http://hdl.handle.net/11449/225451
Resumo: There is still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in vivo and myocardial mechanics in vitro in rats with pressure overload-induced cardiac hypertrophy. Male Wistar rats (70 g) underwent ascending aortic stenosis for 8 weeks (group AAS, n = 9). LV performance was assessed by transthoracic echocardiography under anesthesia. Myocardial function was studied in isolated papillary muscle preparations during isometric contraction. The data were compared with age- and sex-matched sham-operated rats (group C, n = 9). LV weight-to-body weight ratio (C: 2.13 ± 0.14 mg/g; AAS: 3.24 ± 0.44 mg/g), LV relative wall thickness (C: 0.18 ± 0.02; AAS: 0.33 ± 0.09), and LV fractional shortening (C: 54 ± 5%; AAS: 70 ± 8%) were increased in group AAS (P < 0.05). Echocardiographic analysis also indicated a significant association (r = 0.74; P < 0.001) between the percent fractional shortening index and LV relative wall thickness. The performance of AAS isolated muscle revealed that active tension (C: 6.6 ± 1.7 g/mm2; AAS: 6.5 ± 1.5 g/mm2) and maximum rate of tension development (C: 69 ± 21 g/mm2/s; AAS: 69 ± 18 g/mm2/s) were not significantly different from group C (P > 0.05). In conclusion, compensated pressureoverload myocardial hypertrophy is associated with preserved myocardial function and increased ventricular performance. The improved LV function might be due to the ventricular remodeling characterized by an increased relative wall thickness. Copyright © 2004 by the Japanese Heart Journal.
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spelling Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophyAortic stenosisCardiac functionEchocardiographyLeft ventricular hypertrophyPapillary muscleThere is still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in vivo and myocardial mechanics in vitro in rats with pressure overload-induced cardiac hypertrophy. Male Wistar rats (70 g) underwent ascending aortic stenosis for 8 weeks (group AAS, n = 9). LV performance was assessed by transthoracic echocardiography under anesthesia. Myocardial function was studied in isolated papillary muscle preparations during isometric contraction. The data were compared with age- and sex-matched sham-operated rats (group C, n = 9). LV weight-to-body weight ratio (C: 2.13 ± 0.14 mg/g; AAS: 3.24 ± 0.44 mg/g), LV relative wall thickness (C: 0.18 ± 0.02; AAS: 0.33 ± 0.09), and LV fractional shortening (C: 54 ± 5%; AAS: 70 ± 8%) were increased in group AAS (P < 0.05). Echocardiographic analysis also indicated a significant association (r = 0.74; P < 0.001) between the percent fractional shortening index and LV relative wall thickness. The performance of AAS isolated muscle revealed that active tension (C: 6.6 ± 1.7 g/mm2; AAS: 6.5 ± 1.5 g/mm2) and maximum rate of tension development (C: 69 ± 21 g/mm2/s; AAS: 69 ± 18 g/mm2/s) were not significantly different from group C (P > 0.05). In conclusion, compensated pressureoverload myocardial hypertrophy is associated with preserved myocardial function and increased ventricular performance. The improved LV function might be due to the ventricular remodeling characterized by an increased relative wall thickness. Copyright © 2004 by the Japanese Heart Journal.Department of Internal Medicine Botucatu Medical School State University Julio de Mesquita Filho, Botucatu, Sao PauloDepartamento de Clínica Medica Faculdade de Medicina de Botucatu UNESP, Rubiao Junior S/N, 618-000 Botucatu, Sao PauloDepartment of Internal Medicine Botucatu Medical School State University Julio de Mesquita Filho, Botucatu, Sao PauloDepartamento de Clínica Medica Faculdade de Medicina de Botucatu UNESP, Rubiao Junior S/N, 618-000 Botucatu, Sao PauloUniversidade Estadual Paulista (UNESP)Okoshi, Katashi [UNESP]Ribeiro, Henrique Barbosa [UNESP]Okoshi, Marina Politi [UNESP]Matsubara, Beatriz Bojikian [UNESP]Gonçalves, Giancarlo [UNESP]Barros, Reginaldo [UNESP]Cicogna, Antonio Carlos [UNESP]2022-04-28T20:51:09Z2022-04-28T20:51:09Z2004-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article647-656http://dx.doi.org/10.1536/jhj.45.647Japanese Heart Journal, v. 45, n. 4, p. 647-656, 2004.0021-48681348-673Xhttp://hdl.handle.net/11449/22545110.1536/jhj.45.6472-s2.0-6344226354Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJapanese Heart Journalinfo:eu-repo/semantics/openAccess2024-08-14T17:23:33Zoai:repositorio.unesp.br:11449/225451Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
title Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
spellingShingle Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
Okoshi, Katashi [UNESP]
Aortic stenosis
Cardiac function
Echocardiography
Left ventricular hypertrophy
Papillary muscle
title_short Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
title_full Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
title_fullStr Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
title_full_unstemmed Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
title_sort Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
author Okoshi, Katashi [UNESP]
author_facet Okoshi, Katashi [UNESP]
Ribeiro, Henrique Barbosa [UNESP]
Okoshi, Marina Politi [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
Gonçalves, Giancarlo [UNESP]
Barros, Reginaldo [UNESP]
Cicogna, Antonio Carlos [UNESP]
author_role author
author2 Ribeiro, Henrique Barbosa [UNESP]
Okoshi, Marina Politi [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
Gonçalves, Giancarlo [UNESP]
Barros, Reginaldo [UNESP]
Cicogna, Antonio Carlos [UNESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
dc.contributor.author.fl_str_mv Okoshi, Katashi [UNESP]
Ribeiro, Henrique Barbosa [UNESP]
Okoshi, Marina Politi [UNESP]
Matsubara, Beatriz Bojikian [UNESP]
Gonçalves, Giancarlo [UNESP]
Barros, Reginaldo [UNESP]
Cicogna, Antonio Carlos [UNESP]
dc.subject.por.fl_str_mv Aortic stenosis
Cardiac function
Echocardiography
Left ventricular hypertrophy
Papillary muscle
topic Aortic stenosis
Cardiac function
Echocardiography
Left ventricular hypertrophy
Papillary muscle
description There is still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in vivo and myocardial mechanics in vitro in rats with pressure overload-induced cardiac hypertrophy. Male Wistar rats (70 g) underwent ascending aortic stenosis for 8 weeks (group AAS, n = 9). LV performance was assessed by transthoracic echocardiography under anesthesia. Myocardial function was studied in isolated papillary muscle preparations during isometric contraction. The data were compared with age- and sex-matched sham-operated rats (group C, n = 9). LV weight-to-body weight ratio (C: 2.13 ± 0.14 mg/g; AAS: 3.24 ± 0.44 mg/g), LV relative wall thickness (C: 0.18 ± 0.02; AAS: 0.33 ± 0.09), and LV fractional shortening (C: 54 ± 5%; AAS: 70 ± 8%) were increased in group AAS (P < 0.05). Echocardiographic analysis also indicated a significant association (r = 0.74; P < 0.001) between the percent fractional shortening index and LV relative wall thickness. The performance of AAS isolated muscle revealed that active tension (C: 6.6 ± 1.7 g/mm2; AAS: 6.5 ± 1.5 g/mm2) and maximum rate of tension development (C: 69 ± 21 g/mm2/s; AAS: 69 ± 18 g/mm2/s) were not significantly different from group C (P > 0.05). In conclusion, compensated pressureoverload myocardial hypertrophy is associated with preserved myocardial function and increased ventricular performance. The improved LV function might be due to the ventricular remodeling characterized by an increased relative wall thickness. Copyright © 2004 by the Japanese Heart Journal.
publishDate 2004
dc.date.none.fl_str_mv 2004-12-01
2022-04-28T20:51:09Z
2022-04-28T20:51:09Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1536/jhj.45.647
Japanese Heart Journal, v. 45, n. 4, p. 647-656, 2004.
0021-4868
1348-673X
http://hdl.handle.net/11449/225451
10.1536/jhj.45.647
2-s2.0-6344226354
url http://dx.doi.org/10.1536/jhj.45.647
http://hdl.handle.net/11449/225451
identifier_str_mv Japanese Heart Journal, v. 45, n. 4, p. 647-656, 2004.
0021-4868
1348-673X
10.1536/jhj.45.647
2-s2.0-6344226354
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Japanese Heart Journal
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 647-656
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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