Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1536/jhj.45.647 http://hdl.handle.net/11449/225451 |
Resumo: | There is still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in vivo and myocardial mechanics in vitro in rats with pressure overload-induced cardiac hypertrophy. Male Wistar rats (70 g) underwent ascending aortic stenosis for 8 weeks (group AAS, n = 9). LV performance was assessed by transthoracic echocardiography under anesthesia. Myocardial function was studied in isolated papillary muscle preparations during isometric contraction. The data were compared with age- and sex-matched sham-operated rats (group C, n = 9). LV weight-to-body weight ratio (C: 2.13 ± 0.14 mg/g; AAS: 3.24 ± 0.44 mg/g), LV relative wall thickness (C: 0.18 ± 0.02; AAS: 0.33 ± 0.09), and LV fractional shortening (C: 54 ± 5%; AAS: 70 ± 8%) were increased in group AAS (P < 0.05). Echocardiographic analysis also indicated a significant association (r = 0.74; P < 0.001) between the percent fractional shortening index and LV relative wall thickness. The performance of AAS isolated muscle revealed that active tension (C: 6.6 ± 1.7 g/mm2; AAS: 6.5 ± 1.5 g/mm2) and maximum rate of tension development (C: 69 ± 21 g/mm2/s; AAS: 69 ± 18 g/mm2/s) were not significantly different from group C (P > 0.05). In conclusion, compensated pressureoverload myocardial hypertrophy is associated with preserved myocardial function and increased ventricular performance. The improved LV function might be due to the ventricular remodeling characterized by an increased relative wall thickness. Copyright © 2004 by the Japanese Heart Journal. |
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Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophyAortic stenosisCardiac functionEchocardiographyLeft ventricular hypertrophyPapillary muscleThere is still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in vivo and myocardial mechanics in vitro in rats with pressure overload-induced cardiac hypertrophy. Male Wistar rats (70 g) underwent ascending aortic stenosis for 8 weeks (group AAS, n = 9). LV performance was assessed by transthoracic echocardiography under anesthesia. Myocardial function was studied in isolated papillary muscle preparations during isometric contraction. The data were compared with age- and sex-matched sham-operated rats (group C, n = 9). LV weight-to-body weight ratio (C: 2.13 ± 0.14 mg/g; AAS: 3.24 ± 0.44 mg/g), LV relative wall thickness (C: 0.18 ± 0.02; AAS: 0.33 ± 0.09), and LV fractional shortening (C: 54 ± 5%; AAS: 70 ± 8%) were increased in group AAS (P < 0.05). Echocardiographic analysis also indicated a significant association (r = 0.74; P < 0.001) between the percent fractional shortening index and LV relative wall thickness. The performance of AAS isolated muscle revealed that active tension (C: 6.6 ± 1.7 g/mm2; AAS: 6.5 ± 1.5 g/mm2) and maximum rate of tension development (C: 69 ± 21 g/mm2/s; AAS: 69 ± 18 g/mm2/s) were not significantly different from group C (P > 0.05). In conclusion, compensated pressureoverload myocardial hypertrophy is associated with preserved myocardial function and increased ventricular performance. The improved LV function might be due to the ventricular remodeling characterized by an increased relative wall thickness. Copyright © 2004 by the Japanese Heart Journal.Department of Internal Medicine Botucatu Medical School State University Julio de Mesquita Filho, Botucatu, Sao PauloDepartamento de Clínica Medica Faculdade de Medicina de Botucatu UNESP, Rubiao Junior S/N, 618-000 Botucatu, Sao PauloDepartment of Internal Medicine Botucatu Medical School State University Julio de Mesquita Filho, Botucatu, Sao PauloDepartamento de Clínica Medica Faculdade de Medicina de Botucatu UNESP, Rubiao Junior S/N, 618-000 Botucatu, Sao PauloUniversidade Estadual Paulista (UNESP)Okoshi, Katashi [UNESP]Ribeiro, Henrique Barbosa [UNESP]Okoshi, Marina Politi [UNESP]Matsubara, Beatriz Bojikian [UNESP]Gonçalves, Giancarlo [UNESP]Barros, Reginaldo [UNESP]Cicogna, Antonio Carlos [UNESP]2022-04-28T20:51:09Z2022-04-28T20:51:09Z2004-12-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article647-656http://dx.doi.org/10.1536/jhj.45.647Japanese Heart Journal, v. 45, n. 4, p. 647-656, 2004.0021-48681348-673Xhttp://hdl.handle.net/11449/22545110.1536/jhj.45.6472-s2.0-6344226354Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJapanese Heart Journalinfo:eu-repo/semantics/openAccess2024-08-14T17:23:33Zoai:repositorio.unesp.br:11449/225451Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-14T17:23:33Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy |
title |
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy |
spellingShingle |
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy Okoshi, Katashi [UNESP] Aortic stenosis Cardiac function Echocardiography Left ventricular hypertrophy Papillary muscle |
title_short |
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy |
title_full |
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy |
title_fullStr |
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy |
title_full_unstemmed |
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy |
title_sort |
Improved systolic ventricular function with normal myocardial mechanics in compensated cardiac hypertrophy |
author |
Okoshi, Katashi [UNESP] |
author_facet |
Okoshi, Katashi [UNESP] Ribeiro, Henrique Barbosa [UNESP] Okoshi, Marina Politi [UNESP] Matsubara, Beatriz Bojikian [UNESP] Gonçalves, Giancarlo [UNESP] Barros, Reginaldo [UNESP] Cicogna, Antonio Carlos [UNESP] |
author_role |
author |
author2 |
Ribeiro, Henrique Barbosa [UNESP] Okoshi, Marina Politi [UNESP] Matsubara, Beatriz Bojikian [UNESP] Gonçalves, Giancarlo [UNESP] Barros, Reginaldo [UNESP] Cicogna, Antonio Carlos [UNESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) |
dc.contributor.author.fl_str_mv |
Okoshi, Katashi [UNESP] Ribeiro, Henrique Barbosa [UNESP] Okoshi, Marina Politi [UNESP] Matsubara, Beatriz Bojikian [UNESP] Gonçalves, Giancarlo [UNESP] Barros, Reginaldo [UNESP] Cicogna, Antonio Carlos [UNESP] |
dc.subject.por.fl_str_mv |
Aortic stenosis Cardiac function Echocardiography Left ventricular hypertrophy Papillary muscle |
topic |
Aortic stenosis Cardiac function Echocardiography Left ventricular hypertrophy Papillary muscle |
description |
There is still controversy about the relation between changes in myocardial contractile function and global left ventricular (LV) performance during stable concentric hypertrophy. To clarify this, we analyzed LV function in vivo and myocardial mechanics in vitro in rats with pressure overload-induced cardiac hypertrophy. Male Wistar rats (70 g) underwent ascending aortic stenosis for 8 weeks (group AAS, n = 9). LV performance was assessed by transthoracic echocardiography under anesthesia. Myocardial function was studied in isolated papillary muscle preparations during isometric contraction. The data were compared with age- and sex-matched sham-operated rats (group C, n = 9). LV weight-to-body weight ratio (C: 2.13 ± 0.14 mg/g; AAS: 3.24 ± 0.44 mg/g), LV relative wall thickness (C: 0.18 ± 0.02; AAS: 0.33 ± 0.09), and LV fractional shortening (C: 54 ± 5%; AAS: 70 ± 8%) were increased in group AAS (P < 0.05). Echocardiographic analysis also indicated a significant association (r = 0.74; P < 0.001) between the percent fractional shortening index and LV relative wall thickness. The performance of AAS isolated muscle revealed that active tension (C: 6.6 ± 1.7 g/mm2; AAS: 6.5 ± 1.5 g/mm2) and maximum rate of tension development (C: 69 ± 21 g/mm2/s; AAS: 69 ± 18 g/mm2/s) were not significantly different from group C (P > 0.05). In conclusion, compensated pressureoverload myocardial hypertrophy is associated with preserved myocardial function and increased ventricular performance. The improved LV function might be due to the ventricular remodeling characterized by an increased relative wall thickness. Copyright © 2004 by the Japanese Heart Journal. |
publishDate |
2004 |
dc.date.none.fl_str_mv |
2004-12-01 2022-04-28T20:51:09Z 2022-04-28T20:51:09Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1536/jhj.45.647 Japanese Heart Journal, v. 45, n. 4, p. 647-656, 2004. 0021-4868 1348-673X http://hdl.handle.net/11449/225451 10.1536/jhj.45.647 2-s2.0-6344226354 |
url |
http://dx.doi.org/10.1536/jhj.45.647 http://hdl.handle.net/11449/225451 |
identifier_str_mv |
Japanese Heart Journal, v. 45, n. 4, p. 647-656, 2004. 0021-4868 1348-673X 10.1536/jhj.45.647 2-s2.0-6344226354 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Japanese Heart Journal |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
647-656 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128170638966784 |