Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives

Detalhes bibliográficos
Autor(a) principal: Cavalcante, Joeliton dos Santos [UNESP]
Data de Publicação: 2021
Outros Autores: Nogueira Júnior, Francisco Assis, Bezerra Jorge, Roberta Jeane, Almeida, Cayo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1016/j.toxicon.2021.08.016
http://hdl.handle.net/11449/229435
Resumo: Snake venoms are substances mostly composed by proteins and peptides with high biological activity. Local and systemic effects culminate in clinical manifestations induced by these substances. Pain is the most uncomfortable condition, but it has not been well investigated. This review discusses Bothrops snakebite-induced nociception, highlighting molecules involved in the mediation of this process and perspectives in treatment of pain induced by Bothrops snake venoms (B. alternatus, B. asper, B. atrox, B. insularis, B. jararaca, B. pirajai, B. jararacussu, B. lanceolatus, B. leucurus, B. mattogrossensis, B. moojeni). We highlight, the understanding of the nociceptive signaling, especially in snakebite, enables more efficient treatment approaches. Finally, future perspectives for pain treatment concerning snakebite patients are discussed.
id UNSP_1376ca6ec53eaa006cf48961466367fa
oai_identifier_str oai:repositorio.unesp.br:11449/229435
network_acronym_str UNSP
network_name_str Repositório Institucional da UNESP
repository_id_str 2946
spelling Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectivesBothropsInflammationNociceptionSnakebiteTissue damageSnake venoms are substances mostly composed by proteins and peptides with high biological activity. Local and systemic effects culminate in clinical manifestations induced by these substances. Pain is the most uncomfortable condition, but it has not been well investigated. This review discusses Bothrops snakebite-induced nociception, highlighting molecules involved in the mediation of this process and perspectives in treatment of pain induced by Bothrops snake venoms (B. alternatus, B. asper, B. atrox, B. insularis, B. jararaca, B. pirajai, B. jararacussu, B. lanceolatus, B. leucurus, B. mattogrossensis, B. moojeni). We highlight, the understanding of the nociceptive signaling, especially in snakebite, enables more efficient treatment approaches. Finally, future perspectives for pain treatment concerning snakebite patients are discussed.Graduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State UniversityDepartment of Physiology and Pharmacology and Drug Research and Development Center Federal University of CearáCenter of Mathematics Computing Sciences and Cognition Federal University of ABCGraduate Program in Tropical Diseases Botucatu Medical School (FMB) São Paulo State UniversityUniversidade Estadual Paulista (UNESP)Federal University of ABCCavalcante, Joeliton dos Santos [UNESP]Nogueira Júnior, Francisco AssisBezerra Jorge, Roberta JeaneAlmeida, Cayo2022-04-29T08:32:34Z2022-04-29T08:32:34Z2021-10-15info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article105-114http://dx.doi.org/10.1016/j.toxicon.2021.08.016Toxicon, v. 201, p. 105-114.1879-31500041-0101http://hdl.handle.net/11449/22943510.1016/j.toxicon.2021.08.0162-s2.0-85113921383Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengToxiconinfo:eu-repo/semantics/openAccess2024-08-15T15:23:15Zoai:repositorio.unesp.br:11449/229435Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T15:23:15Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
title Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
spellingShingle Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
Cavalcante, Joeliton dos Santos [UNESP]
Bothrops
Inflammation
Nociception
Snakebite
Tissue damage
title_short Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
title_full Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
title_fullStr Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
title_full_unstemmed Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
title_sort Pain modulated by Bothrops snake venoms: Mechanisms of nociceptive signaling and therapeutic perspectives
author Cavalcante, Joeliton dos Santos [UNESP]
author_facet Cavalcante, Joeliton dos Santos [UNESP]
Nogueira Júnior, Francisco Assis
Bezerra Jorge, Roberta Jeane
Almeida, Cayo
author_role author
author2 Nogueira Júnior, Francisco Assis
Bezerra Jorge, Roberta Jeane
Almeida, Cayo
author2_role author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual Paulista (UNESP)
Federal University of ABC
dc.contributor.author.fl_str_mv Cavalcante, Joeliton dos Santos [UNESP]
Nogueira Júnior, Francisco Assis
Bezerra Jorge, Roberta Jeane
Almeida, Cayo
dc.subject.por.fl_str_mv Bothrops
Inflammation
Nociception
Snakebite
Tissue damage
topic Bothrops
Inflammation
Nociception
Snakebite
Tissue damage
description Snake venoms are substances mostly composed by proteins and peptides with high biological activity. Local and systemic effects culminate in clinical manifestations induced by these substances. Pain is the most uncomfortable condition, but it has not been well investigated. This review discusses Bothrops snakebite-induced nociception, highlighting molecules involved in the mediation of this process and perspectives in treatment of pain induced by Bothrops snake venoms (B. alternatus, B. asper, B. atrox, B. insularis, B. jararaca, B. pirajai, B. jararacussu, B. lanceolatus, B. leucurus, B. mattogrossensis, B. moojeni). We highlight, the understanding of the nociceptive signaling, especially in snakebite, enables more efficient treatment approaches. Finally, future perspectives for pain treatment concerning snakebite patients are discussed.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-15
2022-04-29T08:32:34Z
2022-04-29T08:32:34Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1016/j.toxicon.2021.08.016
Toxicon, v. 201, p. 105-114.
1879-3150
0041-0101
http://hdl.handle.net/11449/229435
10.1016/j.toxicon.2021.08.016
2-s2.0-85113921383
url http://dx.doi.org/10.1016/j.toxicon.2021.08.016
http://hdl.handle.net/11449/229435
identifier_str_mv Toxicon, v. 201, p. 105-114.
1879-3150
0041-0101
10.1016/j.toxicon.2021.08.016
2-s2.0-85113921383
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Toxicon
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 105-114
dc.source.none.fl_str_mv Scopus
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
_version_ 1808128191527649280

Registros relacionados