Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1016/S1808-8694(15)30785-0 http://hdl.handle.net/11449/225508 |
Resumo: | Currently, much is discussed regarding the pre-malignant nature of mouth mucosa lichen planus. Aim: The present study aims at analyzing the alterations found in the epithelial cells present in the oral cavity lichen planus, comparing them to those found in epidermoid carcinoma. Materials and Methods: Histological cross-sections of oral lichen planus and epidermoid carcinoma, dyed by hematoxylineosin, were analyzed through light microscopy. Result: the most frequently found alterations in oral lichen planus were: an increase in the nucleus/cytoplasm relation (93-33%), nucleus membrane thickness (86.67%) and bi-nucleus or multinucleous (86.67%). The Student t test (alpha=5%) revealed a statistically significant difference between the average number of cell alterations in oral lichen planus (5.87±1.57) and in epidermoid carcinoma (7.60±1.81). As to fhe types of alterations, the chi-squared test also revealed statistically significant differences among the lesions assessed in relation to the following cell alterations: nuclear excess chromatism, atypical mitoses, cellular pleomorphism and abnormal cell differentiation (p<0.05). Conclusion: Despite the fact that in some cases, some padiologists may make mistakes in the histopathological diagnosis of oral lichen planus, the results obtained in this study show that the alterations present in oral lichen planus differ considerably from those seen in epidermoid carcinoma, thus showing how distinct these two diseases are. |
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Repositório Institucional da UNESP |
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spelling |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosaEpidermoid carcinomaLichen planusMouth mucosaCurrently, much is discussed regarding the pre-malignant nature of mouth mucosa lichen planus. Aim: The present study aims at analyzing the alterations found in the epithelial cells present in the oral cavity lichen planus, comparing them to those found in epidermoid carcinoma. Materials and Methods: Histological cross-sections of oral lichen planus and epidermoid carcinoma, dyed by hematoxylineosin, were analyzed through light microscopy. Result: the most frequently found alterations in oral lichen planus were: an increase in the nucleus/cytoplasm relation (93-33%), nucleus membrane thickness (86.67%) and bi-nucleus or multinucleous (86.67%). The Student t test (alpha=5%) revealed a statistically significant difference between the average number of cell alterations in oral lichen planus (5.87±1.57) and in epidermoid carcinoma (7.60±1.81). As to fhe types of alterations, the chi-squared test also revealed statistically significant differences among the lesions assessed in relation to the following cell alterations: nuclear excess chromatism, atypical mitoses, cellular pleomorphism and abnormal cell differentiation (p<0.05). Conclusion: Despite the fact that in some cases, some padiologists may make mistakes in the histopathological diagnosis of oral lichen planus, the results obtained in this study show that the alterations present in oral lichen planus differ considerably from those seen in epidermoid carcinoma, thus showing how distinct these two diseases are.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Department of General Pathology FOSJC UNESPDepartment of Oral Pathology FOSJC UNESPJardim Esplanada II, Rua Irmã Maria Demétria Kfruri 196, 12242-500 Sao Jose dos Campos Sao Paulo SPCAPESDepartment of General Pathology FOSJC UNESPDepartment of Oral Pathology FOSJC UNESPUniversidade Estadual Paulista (UNESP)Jardim Esplanada IICAPESDe Sousa, Fernando Augusto Cervantes GarciaParadella, Thaís CachutéBrandão, Adriana Aigotti Haberbeck [UNESP]Rosa, Luiz Eduardo Blunter [UNESP]2022-04-28T20:52:54Z2022-04-28T20:52:54Z2009-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article245-248http://dx.doi.org/10.1016/S1808-8694(15)30785-0Brazilian Journal of Otorhinolaryngology, v. 75, n. 2, p. 245-248, 2009.1808-86861808-8694http://hdl.handle.net/11449/22550810.1016/S1808-8694(15)30785-02-s2.0-67549140236Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengBrazilian Journal of Otorhinolaryngologyinfo:eu-repo/semantics/openAccess2022-04-28T20:52:54Zoai:repositorio.unesp.br:11449/225508Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T16:47:33.639571Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa |
title |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa |
spellingShingle |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa De Sousa, Fernando Augusto Cervantes Garcia Epidermoid carcinoma Lichen planus Mouth mucosa |
title_short |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa |
title_full |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa |
title_fullStr |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa |
title_full_unstemmed |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa |
title_sort |
Comparative study of cell alterations in oral lichen planus and epidermoid carcinoma of the mouth mucosa |
author |
De Sousa, Fernando Augusto Cervantes Garcia |
author_facet |
De Sousa, Fernando Augusto Cervantes Garcia Paradella, Thaís Cachuté Brandão, Adriana Aigotti Haberbeck [UNESP] Rosa, Luiz Eduardo Blunter [UNESP] |
author_role |
author |
author2 |
Paradella, Thaís Cachuté Brandão, Adriana Aigotti Haberbeck [UNESP] Rosa, Luiz Eduardo Blunter [UNESP] |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (UNESP) Jardim Esplanada II CAPES |
dc.contributor.author.fl_str_mv |
De Sousa, Fernando Augusto Cervantes Garcia Paradella, Thaís Cachuté Brandão, Adriana Aigotti Haberbeck [UNESP] Rosa, Luiz Eduardo Blunter [UNESP] |
dc.subject.por.fl_str_mv |
Epidermoid carcinoma Lichen planus Mouth mucosa |
topic |
Epidermoid carcinoma Lichen planus Mouth mucosa |
description |
Currently, much is discussed regarding the pre-malignant nature of mouth mucosa lichen planus. Aim: The present study aims at analyzing the alterations found in the epithelial cells present in the oral cavity lichen planus, comparing them to those found in epidermoid carcinoma. Materials and Methods: Histological cross-sections of oral lichen planus and epidermoid carcinoma, dyed by hematoxylineosin, were analyzed through light microscopy. Result: the most frequently found alterations in oral lichen planus were: an increase in the nucleus/cytoplasm relation (93-33%), nucleus membrane thickness (86.67%) and bi-nucleus or multinucleous (86.67%). The Student t test (alpha=5%) revealed a statistically significant difference between the average number of cell alterations in oral lichen planus (5.87±1.57) and in epidermoid carcinoma (7.60±1.81). As to fhe types of alterations, the chi-squared test also revealed statistically significant differences among the lesions assessed in relation to the following cell alterations: nuclear excess chromatism, atypical mitoses, cellular pleomorphism and abnormal cell differentiation (p<0.05). Conclusion: Despite the fact that in some cases, some padiologists may make mistakes in the histopathological diagnosis of oral lichen planus, the results obtained in this study show that the alterations present in oral lichen planus differ considerably from those seen in epidermoid carcinoma, thus showing how distinct these two diseases are. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-01-01 2022-04-28T20:52:54Z 2022-04-28T20:52:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/S1808-8694(15)30785-0 Brazilian Journal of Otorhinolaryngology, v. 75, n. 2, p. 245-248, 2009. 1808-8686 1808-8694 http://hdl.handle.net/11449/225508 10.1016/S1808-8694(15)30785-0 2-s2.0-67549140236 |
url |
http://dx.doi.org/10.1016/S1808-8694(15)30785-0 http://hdl.handle.net/11449/225508 |
identifier_str_mv |
Brazilian Journal of Otorhinolaryngology, v. 75, n. 2, p. 245-248, 2009. 1808-8686 1808-8694 10.1016/S1808-8694(15)30785-0 2-s2.0-67549140236 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Otorhinolaryngology |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
245-248 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128701826596864 |