Nanotechnology-based drug delivery systems and herbal medicines: a review
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.2147/IJN.S52634 http://hdl.handle.net/11449/112074 |
Resumo: | Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nano-structured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology- based drug delivery systems and herbal medicines. |
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Nanotechnology-based drug delivery systems and herbal medicines: a reviewnatural productsherbal medicinesnanotechnologydrug delivery systemsbiological activityHerbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nano-structured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology- based drug delivery systems and herbal medicines.Sao Paulo State Univ, Sch Pharmaceut Sci, Postgrad Program Pharmaceut Sci, BR-14801902 Araraquara, SP, BrazilSao Paulo State Univ, Sch Pharmaceut Sci, Postgrad Program Pharmaceut Sci, BR-14801902 Araraquara, SP, BrazilDove Medical Press LtdUniversidade Estadual Paulista (Unesp)Bonifacio, Bruna Vidal [UNESP]Silva, Patricia Bento da [UNESP]Santos Ramos, Matheus Aparecido dos [UNESP]Silveira Negri, Kamila Maria [UNESP]Bauab, Taís Maria [UNESP]Chorilli, Marlus [UNESP]2014-12-03T13:09:13Z2014-12-03T13:09:13Z2014-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1-15application/pdfhttp://dx.doi.org/10.2147/IJN.S52634International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 1-15, 2014.1178-2013http://hdl.handle.net/11449/11207410.2147/IJN.S52634WOS:000329346000001WOS000329346000001.pdf4910754838277580Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInternational Journal of Nanomedicine4.3701,225info:eu-repo/semantics/openAccess2024-06-24T13:45:18Zoai:repositorio.unesp.br:11449/112074Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:30:10.772725Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Nanotechnology-based drug delivery systems and herbal medicines: a review |
title |
Nanotechnology-based drug delivery systems and herbal medicines: a review |
spellingShingle |
Nanotechnology-based drug delivery systems and herbal medicines: a review Bonifacio, Bruna Vidal [UNESP] natural products herbal medicines nanotechnology drug delivery systems biological activity |
title_short |
Nanotechnology-based drug delivery systems and herbal medicines: a review |
title_full |
Nanotechnology-based drug delivery systems and herbal medicines: a review |
title_fullStr |
Nanotechnology-based drug delivery systems and herbal medicines: a review |
title_full_unstemmed |
Nanotechnology-based drug delivery systems and herbal medicines: a review |
title_sort |
Nanotechnology-based drug delivery systems and herbal medicines: a review |
author |
Bonifacio, Bruna Vidal [UNESP] |
author_facet |
Bonifacio, Bruna Vidal [UNESP] Silva, Patricia Bento da [UNESP] Santos Ramos, Matheus Aparecido dos [UNESP] Silveira Negri, Kamila Maria [UNESP] Bauab, Taís Maria [UNESP] Chorilli, Marlus [UNESP] |
author_role |
author |
author2 |
Silva, Patricia Bento da [UNESP] Santos Ramos, Matheus Aparecido dos [UNESP] Silveira Negri, Kamila Maria [UNESP] Bauab, Taís Maria [UNESP] Chorilli, Marlus [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Bonifacio, Bruna Vidal [UNESP] Silva, Patricia Bento da [UNESP] Santos Ramos, Matheus Aparecido dos [UNESP] Silveira Negri, Kamila Maria [UNESP] Bauab, Taís Maria [UNESP] Chorilli, Marlus [UNESP] |
dc.subject.por.fl_str_mv |
natural products herbal medicines nanotechnology drug delivery systems biological activity |
topic |
natural products herbal medicines nanotechnology drug delivery systems biological activity |
description |
Herbal medicines have been widely used around the world since ancient times. The advancement of phytochemical and phytopharmacological sciences has enabled elucidation of the composition and biological activities of several medicinal plant products. The effectiveness of many species of medicinal plants depends on the supply of active compounds. Most of the biologically active constituents of extracts, such as flavonoids, tannins, and terpenoids, are highly soluble in water, but have low absorption, because they are unable to cross the lipid membranes of the cells, have excessively high molecular size, or are poorly absorbed, resulting in loss of bioavailability and efficacy. Some extracts are not used clinically because of these obstacles. It has been widely proposed to combine herbal medicine with nanotechnology, because nano-structured systems might be able to potentiate the action of plant extracts, reducing the required dose and side effects, and improving activity. Nanosystems can deliver the active constituent at a sufficient concentration during the entire treatment period, directing it to the desired site of action. Conventional treatments do not meet these requirements. The purpose of this study is to review nanotechnology- based drug delivery systems and herbal medicines. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-12-03T13:09:13Z 2014-12-03T13:09:13Z 2014-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.2147/IJN.S52634 International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 1-15, 2014. 1178-2013 http://hdl.handle.net/11449/112074 10.2147/IJN.S52634 WOS:000329346000001 WOS000329346000001.pdf 4910754838277580 |
url |
http://dx.doi.org/10.2147/IJN.S52634 http://hdl.handle.net/11449/112074 |
identifier_str_mv |
International Journal Of Nanomedicine. Albany: Dove Medical Press Ltd, v. 9, p. 1-15, 2014. 1178-2013 10.2147/IJN.S52634 WOS:000329346000001 WOS000329346000001.pdf 4910754838277580 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
International Journal of Nanomedicine 4.370 1,225 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1-15 application/pdf |
dc.publisher.none.fl_str_mv |
Dove Medical Press Ltd |
publisher.none.fl_str_mv |
Dove Medical Press Ltd |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128521420144640 |